DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
SRRLLDDIS
Uniprot ID:
P46821
Source protein:
Microtubule-associated protein 1B
Source gene:
MAP1B
Class:
DEG_APCC_DBOX_1
Location:
1980:1988
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.9967
ASA_SCORE:
101.2556
COIL:
0.7867
CONS_SCORE:
0.488
DSS_SCORE:
0.5661
HELIX:
0.1309
FCONS_SCORE:
1.1028
RIG_SCORE:
0.7457
Degron related mutations and impact score
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Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.S1994F
TCGA-DJ-A2Q7
THCA
TCGA
SRRLLDDIS
DEG_APCC_DBOX_1
0.6111
p.S1994F
DO39004
THCA
ICGC
SRRLLDDIS
DEG_APCC_DBOX_1
0.6111
p.S1973N
DO229054
LICA
ICGC
SRRLLDDIS
DEG_APCC_DBOX_1
0.5833
p.Y1972H
TCGA-BR-6452
STAD
TCGA
SRRLLDDIS
DEG_APCC_DBOX_1
0.5556
p.Y1972H
DO38404
STAD
ICGC
SRRLLDDIS
DEG_APCC_DBOX_1
0.5556
p.G1997C
TCGA-ZF-A9RC
BLCA
TCGA
SRRLLDDIS
DEG_APCC_DBOX_1
0.0833
p.G1997C
DO219068
BLCA
ICGC
SRRLLDDIS
DEG_APCC_DBOX_1
0.0833
p.G1971D
DO229054
LICA
ICGC
SRRLLDDIS
DEG_APCC_DBOX_1
0.0833
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Drug responses associated with MAP1B mutations
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Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
No data available in table
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All proteins holding degron of SRRLLDDIS
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Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
P46821
Microtubule-associated protein 1B
DEG_APCC_DBOX_1
1980:1988
SRRLLDDIS
APC,CDC20,FZR1
0.9967
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