DegronMD

Uniprot ID: P46821

Source protein: Microtubule-associated protein 1B

Source gene: MAP1B

Class: DEG_APCC_DBOX_1

Location: 1980:1988

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9967

ASA_SCORE: 101.2556

COIL: 0.7867

CONS_SCORE: 0.488

DSS_SCORE: 0.5661

HELIX: 0.1309

FCONS_SCORE: 1.1028

RIG_SCORE: 0.7457

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Y1972H	TCGA-BR-6452	STAD	TCGA	SRRLLDDIS	DEG_APCC_DBOX_1	0.5556
p.Y1972H	DO38404	STAD	ICGC	SRRLLDDIS	DEG_APCC_DBOX_1	0.5556
p.S1994F	TCGA-DJ-A2Q7	THCA	TCGA	SRRLLDDIS	DEG_APCC_DBOX_1	0.6111
p.S1994F	DO39004	THCA	ICGC	SRRLLDDIS	DEG_APCC_DBOX_1	0.6111
p.G1997C	TCGA-ZF-A9RC	BLCA	TCGA	SRRLLDDIS	DEG_APCC_DBOX_1	0.0833
p.G1997C	DO219068	BLCA	ICGC	SRRLLDDIS	DEG_APCC_DBOX_1	0.0833
p.G1971D	DO229054	LICA	ICGC	SRRLLDDIS	DEG_APCC_DBOX_1	0.0833
p.S1973N	DO229054	LICA	ICGC	SRRLLDDIS	DEG_APCC_DBOX_1	0.5833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P46821	Microtubule-associated protein 1B	DEG_APCC_DBOX_1	1980:1988	SRRLLDDIS	APC,CDC20,FZR1	0.9967	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons