DegronMD

Uniprot ID: P30305

Source protein: M-phase inducer phosphatase 2

Source gene: CDC25B

Class: DEG_APCC_DBOX_1

Location: 81:89

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8178

ASA_SCORE: 95.7222

COIL: 0.6916

CONS_SCORE: 0.2553

DSS_SCORE: 0.359

HELIX: 0.2798

FCONS_SCORE: 0.8782

RIG_SCORE: 0.7579

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L77Q	TCGA-06-1801	GBM	TCGA	SRSRLTHLS	DEG_APCC_DBOX_1	0.2222
p.L77Q	DO11986	GBM	ICGC	SRSRLTHLS	DEG_APCC_DBOX_1	0.2222
p.S89Y	TCGA-22-4601	LUSC	TCGA	SRSRLTHLS	DEG_APCC_DBOX_1	0.712
p.T86M	TCGA-61-1906	OV	TCGA	SRSRLTHLS	DEG_APCC_DBOX_1	0.7423
p.T86M	DO30070	OV	ICGC	SRSRLTHLS	DEG_APCC_DBOX_1	0.7423
p.R92Q	TCGA-AC-A62V	BRCA	TCGA	SRSRLTHLS	DEG_APCC_DBOX_1	0.25
p.E96K	TCGA-B5-A11E	UCEC	TCGA	SRSRLTHLS	DEG_APCC_DBOX_1	0.1389
p.E96K	TCGA-EY-A1GI	UCEC	TCGA	SRSRLTHLS	DEG_APCC_DBOX_1	0.1389
p.R82H	TCGA-B5-A3FC	UCEC	TCGA	SRSRLTHLS	DEG_APCC_DBOX_1	0.8244
p.R82H	DO41871	UCEC	ICGC	SRSRLTHLS	DEG_APCC_DBOX_1	0.8244
p.R84H	TCGA-FI-A2D5	UCEC	TCGA	SRSRLTHLS	DEG_APCC_DBOX_1	0.7133
p.S96I	DO223732	CESC	ICGC	SRSRLTHLS	DEG_APCC_DBOX_1	0.1389
p.V98L	DO228390	LICA	ICGC	SRSRLTHLS	DEG_APCC_DBOX_1	0.0833
p.R73L	DO229022	LICA	ICGC	SRSRLTHLS	DEG_APCC_DBOX_1	0.1111
p.S96C	DO52205	LIHC	ICGC	SRSRLTHLS	DEG_APCC_DBOX_1	0.1389
p.S89T	SIDM00524	Small Cell Lung Carcinoma	GDSC	SRSRLTHLS	DEG_APCC_DBOX_1	0.7116
p.S89T	ACH-000703	Lung Cancer	CCLE	SRSRLTHLS	DEG_APCC_DBOX_1	0.7116
p.S89T	DMS-79	lung	COSMIC	SRSRLTHLS	DEG_APCC_DBOX_1	0.7116
p.R93Q	SIDM00079	Ovarian Carcinoma	GDSC	SRSRLTHLS	DEG_APCC_DBOX_1	0.2222
p.R93Q	ACH-000811	Ovarian Cancer	CCLE	SRSRLTHLS	DEG_APCC_DBOX_1	0.2222
p.R93Q	SK-OV-3	ovary	COSMIC	SRSRLTHLS	DEG_APCC_DBOX_1	0.2222
p.K71T	SIDM01611	Endometrial Carcinoma	GDSC	SRSRLTHLS	DEG_APCC_DBOX_1	0.5
p.K71T	ACH-000996	Endometrial/Uterine Cancer	CCLE	SRSRLTHLS	DEG_APCC_DBOX_1	0.5
p.K71E	ACH-001421	Eye Cancer	CCLE	SRSRLTHLS	DEG_APCC_DBOX_1	0.5
p.S95Y	ACH-002396	Bone Cancer	CCLE	SRSRLTHLS	DEG_APCC_DBOX_1	0.1667
p.S95Y	Sarc9371	bone	COSMIC	SRSRLTHLS	DEG_APCC_DBOX_1	0.1667
p.S86L	JHU-011	upper_aerodigestive_tract	COSMIC	SRSRLTHLS	DEG_APCC_DBOX_1	0.7667
p.R79Q	SK-OV-3	ovary	COSMIC	SRSRLTHLS	DEG_APCC_DBOX_1	0.2778
p.S75T	DMS-79	lung	COSMIC	SRSRLTHLS	DEG_APCC_DBOX_1	0.1667
p.V90A	EN	endometrium	COSMIC	SRSRLTHLS	DEG_APCC_DBOX_1	0.3056
p.S81Y	Sarc9371	bone	COSMIC	SRSRLTHLS	DEG_APCC_DBOX_1	0.6009

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: SRSRLTHLS

Degron related mutations and impact score

Drug responses associated with CDC25B mutations

All proteins holding degron of SRSRLTHLS

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P30305	M-phase inducer phosphatase 2	DEG_APCC_DBOX_1	81:89	SRSRLTHLS	APC,CDC20,FZR1	0.8178	More...