DegronMD

Uniprot ID: Q3MIW9

Source protein: Mucin-like protein 3

Source gene: MUCL3

Class: DEG_APCC_DBOX_1

Location: 404:412

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7451

ASA_SCORE: 97.1222

COIL: 0.8843

CONS_SCORE: 0.654

DSS_SCORE: 0.464

HELIX: 0.0579

FCONS_SCORE: 1.1565

RIG_SCORE: 0.7577

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A397V	SIDM00544	Neuroblastoma	GDSC	SRTKLSSIT	DEG_APCC_DBOX_1	0.1389
p.A397V	GOTO	autonomic_ganglia	COSMIC	SRTKLSSIT	DEG_APCC_DBOX_1	0.1389
p.A409T	SIDM01169	Ovarian Carcinoma	GDSC	SRTKLSSIT	DEG_APCC_DBOX_1	0.7139
p.A409T	SIDM00557	Neuroblastoma	GDSC	SRTKLSSIT	DEG_APCC_DBOX_1	0.7139
p.A409T	TOV-21G	ovary	COSMIC	SRTKLSSIT	DEG_APCC_DBOX_1	0.7139
p.A409T	KP-N-RT-BM-1	autonomic_ganglia	COSMIC	SRTKLSSIT	DEG_APCC_DBOX_1	0.7139
p.K412N	SIDM00557	Neuroblastoma	GDSC	SRTKLSSIT	DEG_APCC_DBOX_1	0.6918
p.K412N	KP-N-RT-BM-1	autonomic_ganglia	COSMIC	SRTKLSSIT	DEG_APCC_DBOX_1	0.6918
p.E419D	SIDM00730	Small Cell Lung Carcinoma	GDSC	SRTKLSSIT	DEG_APCC_DBOX_1	0.1389
p.E419D	NCI-H2227	lung	COSMIC	SRTKLSSIT	DEG_APCC_DBOX_1	0.1389
p.R413K	NB14	autonomic_ganglia	COSMIC	SRTKLSSIT	DEG_APCC_DBOX_1	0.3056
p.A407V	KCL-22	haematopoietic_and_lymphoid_tissue	COSMIC	SRTKLSSIT	DEG_APCC_DBOX_1	0.6936
p.A407V	KP-2	pancreas	COSMIC	SRTKLSSIT	DEG_APCC_DBOX_1	0.6936
p.A407V	SBC-3	lung	COSMIC	SRTKLSSIT	DEG_APCC_DBOX_1	0.6936
p.S398F	KYSE-220	oesophagus	COSMIC	SRTKLSSIT	DEG_APCC_DBOX_1	0.1667
p.T403A	SNU-1040	large_intestine	COSMIC	SRTKLSSIT	DEG_APCC_DBOX_1	0.3056
p.A403T	NALM-6	haematopoietic_and_lymphoid_tissue	COSMIC	SRTKLSSIT	DEG_APCC_DBOX_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q3MIW9	Mucin-like protein 3	DEG_APCC_DBOX_1	404:412	SRTKLSSIT	APC,CDC20,FZR1	0.7451	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons