DegronMD

Uniprot ID: O00472

Source protein: RNA polymerase II elongation factor ELL2

Source gene: ELL2

Class: DEG_APCC_DBOX_1

Location: 431:439

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9959

ASA_SCORE: 76.1

COIL: 0.8082

CONS_SCORE: 0.356

DSS_SCORE: 0.5805

HELIX: 0.0867

FCONS_SCORE: 1.0125

RIG_SCORE: 0.6962

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L445I	TCGA-19-1390	GBM	TCGA	SRTSLETLP	DEG_APCC_DBOX_1	0.1667
p.I421N	TCGA-55-A490	LUAD	TCGA	SRTSLETLP	DEG_APCC_DBOX_1	0.0556
p.L435V	TCGA-DG-A2KK	CESC	TCGA	SRTSLETLP	DEG_APCC_DBOX_1	0.6765
p.S431C	TCGA-RS-A6TO	HNSC	TCGA	SRTSLETLP	DEG_APCC_DBOX_1	0.643
p.T430A	ACH-000960	Leukemia	CCLE	SRTSLETLP	DEG_APCC_DBOX_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O00472	RNA polymerase II elongation factor ELL2	DEG_APCC_DBOX_1	431:439	SRTSLETLP	APC,CDC20,FZR1	0.9959	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons