DegronMD

Uniprot ID: Q9H1Z4

Source protein: WD repeat-containing protein 13

Source gene: WDR13

Class: DEG_APCC_DBOX_1

Location: 86:94

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5937

ASA_SCORE: 38.5889

COIL: 0.449

CONS_SCORE: 0.5826

DSS_SCORE: 0.5005

HELIX: 0.015

FCONS_SCORE: 1.1002

RIG_SCORE: 0.7278

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Y78F	TCGA-44-2657	LUAD	TCGA	SRTTLDRME	DEG_APCC_DBOX_1	0.1111
p.Y78F	DO25020	LUAD	ICGC	SRTTLDRME	DEG_APCC_DBOX_1	0.1111
p.V83I	TCGA-AA-3854	COAD	TCGA	SRTTLDRME	DEG_APCC_DBOX_1	0.25
p.V83I	DO10148	COAD	ICGC	SRTTLDRME	DEG_APCC_DBOX_1	0.25
p.A77S	TCGA-CK-4951	COAD	TCGA	SRTTLDRME	DEG_APCC_DBOX_1	0.0833
p.A77S	DO10582	COAD	ICGC	SRTTLDRME	DEG_APCC_DBOX_1	0.0833
p.D99N	TCGA-D3-A8GV	SKCM	TCGA	SRTTLDRME	DEG_APCC_DBOX_1	0.1944
p.D99N	DO219477	SKCM	ICGC	SRTTLDRME	DEG_APCC_DBOX_1	0.1944
p.L90F	TCGA-DK-A3IS	BLCA	TCGA	SRTTLDRME	DEG_APCC_DBOX_1	0.6981
p.L90F	DO566	BLCA	ICGC	SRTTLDRME	DEG_APCC_DBOX_1	0.6981
p.L90F	ACH-001377	Pancreatic Cancer	CCLE	SRTTLDRME	DEG_APCC_DBOX_1	0.6981
p.R92S	TCGA-EE-A3AC	SKCM	TCGA	SRTTLDRME	DEG_APCC_DBOX_1	0.6316
p.R92S	DO37631	SKCM	ICGC	SRTTLDRME	DEG_APCC_DBOX_1	0.6316
p.R92H	DO233941	GACA	ICGC	SRTTLDRME	DEG_APCC_DBOX_1	0.7133
p.R84S	DO229044	LICA	ICGC	SRTTLDRME	DEG_APCC_DBOX_1	0.2778
p.R87H	SIDM00839	Colorectal Carcinoma	GDSC	SRTTLDRME	DEG_APCC_DBOX_1	0.8244
p.R87H	ACH-000950	Colon/Colorectal Cancer	CCLE	SRTTLDRME	DEG_APCC_DBOX_1	0.8244
p.R87H	LoVo	large_intestine	COSMIC	SRTTLDRME	DEG_APCC_DBOX_1	0.8244

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9H1Z4	WD repeat-containing protein 13	DEG_APCC_DBOX_1	86:94	SRTTLDRME	APC,CDC20,FZR1	0.5937	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons