DegronMD

Uniprot ID: Q8N0Z8

Source protein: tRNA pseudouridine synthase-like 1

Source gene: PUSL1

Class: DEG_APCC_DBOX_1

Location: 127:135

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5388

ASA_SCORE: 28.6667

COIL: 0.1331

CONS_SCORE: 0.6125

DSS_SCORE: 0.13

HELIX: 0.0132

FCONS_SCORE: 1.375

RIG_SCORE: 0.8388

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T129A	TCGA-06-5416	GBM	TCGA	SRTYLYRLA	DEG_APCC_DBOX_1	0.6028
p.T129A	DO10880	GBM	ICGC	SRTYLYRLA	DEG_APCC_DBOX_1	0.6028
p.R140W	TCGA-2J-AABO	PAAD	TCGA	SRTYLYRLA	DEG_APCC_DBOX_1	0.1944
p.R140W	DO51666	PAAD	ICGC	SRTYLYRLA	DEG_APCC_DBOX_1	0.1944
p.A125T	TCGA-CU-A0YR	BLCA	TCGA	SRTYLYRLA	DEG_APCC_DBOX_1	0.2778
p.A125T	DO449	BLCA	ICGC	SRTYLYRLA	DEG_APCC_DBOX_1	0.2778
p.L134M	TCGA-EE-A2GI	SKCM	TCGA	SRTYLYRLA	DEG_APCC_DBOX_1	0.5999
p.L134M	DO37410	SKCM	ICGC	SRTYLYRLA	DEG_APCC_DBOX_1	0.5999
p.Y130C	DO230326	COCA	ICGC	SRTYLYRLA	DEG_APCC_DBOX_1	0.5976
p.R133L	DO228974	LICA	ICGC	SRTYLYRLA	DEG_APCC_DBOX_1	0.7316

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8N0Z8	tRNA pseudouridine synthase-like 1	DEG_APCC_DBOX_1	127:135	SRTYLYRLA	APC,CDC20,FZR1	0.5388	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons