DegronMD

Uniprot ID: Q14289

Source protein: Protein-tyrosine kinase 2-beta

Source gene: PTK2B

Class: DEG_APCC_DBOX_1

Location: 9:17

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8131

ASA_SCORE: 93.0778

COIL: 0.7936

CONS_SCORE: 0.2801

DSS_SCORE: 0.484

HELIX: 0.1634

FCONS_SCORE: 1.1319

RIG_SCORE: 0.7146

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E6D	TCGA-42-2589	OV	TCGA	SRVKLGTLR	DEG_APCC_DBOX_1	0.25
p.E6D	DO31130	OV	ICGC	SRVKLGTLR	DEG_APCC_DBOX_1	0.25
p.E6K	TCGA-73-4676	LUAD	TCGA	SRVKLGTLR	DEG_APCC_DBOX_1	0.25
p.E6K	DO24810	LUAD	ICGC	SRVKLGTLR	DEG_APCC_DBOX_1	0.25
p.R18W	TCGA-AB-2828	LAML	TCGA	SRVKLGTLR	DEG_APCC_DBOX_1	0.3056
p.R18W	DO21571	LAML	ICGC	SRVKLGTLR	DEG_APCC_DBOX_1	0.3056
p.L13S	TCGA-AP-A0LM	UCEC	TCGA	SRVKLGTLR	DEG_APCC_DBOX_1	0.7667
p.L13S	DO43306	UCEC	ICGC	SRVKLGTLR	DEG_APCC_DBOX_1	0.7667
p.P19S	TCGA-AX-A2HD	UCEC	TCGA	SRVKLGTLR	DEG_APCC_DBOX_1	0.2778
p.P19S	DO42608	UCEC	ICGC	SRVKLGTLR	DEG_APCC_DBOX_1	0.2778
p.P22H	TCGA-ER-A19T	SKCM	TCGA	SRVKLGTLR	DEG_APCC_DBOX_1	0.1944
p.P22H	DO51251	SKCM	ICGC	SRVKLGTLR	DEG_APCC_DBOX_1	0.1944
p.G2R	DO222973	BTCA	ICGC	SRVKLGTLR	DEG_APCC_DBOX_1	0.5833
p.S9I	DO229018	LICA	ICGC	SRVKLGTLR	DEG_APCC_DBOX_1	0.7341
p.S9I	SIDM01205	Acute Myeloid Leukemia	GDSC	SRVKLGTLR	DEG_APCC_DBOX_1	0.7341
p.S9I	SIDM01195	Acute Myeloid Leukemia	GDSC	SRVKLGTLR	DEG_APCC_DBOX_1	0.7341
p.S9I	ACH-002314	Leukemia	CCLE	SRVKLGTLR	DEG_APCC_DBOX_1	0.7341
p.S9I	TUR	haematopoietic_and_lymphoid_tissue	COSMIC	SRVKLGTLR	DEG_APCC_DBOX_1	0.7341
p.G2W	DO26746	LUSC	ICGC	SRVKLGTLR	DEG_APCC_DBOX_1	0.5833
p.T4A	DO228371	MALY	ICGC	SRVKLGTLR	DEG_APCC_DBOX_1	0.1944
p.R18Q	DO233292	NACA	ICGC	SRVKLGTLR	DEG_APCC_DBOX_1	0.3056
p.Q9H	DO220065	SARC	ICGC	SRVKLGTLR	DEG_APCC_DBOX_1	0.7582
p.L12I	DO37431	SKCM	ICGC	SRVKLGTLR	DEG_APCC_DBOX_1	0.7174
p.N20D	DO42673	UCEC	ICGC	SRVKLGTLR	DEG_APCC_DBOX_1	0.25
p.R18L	SIDM00810	Non-Small Cell Lung Carcinoma	GDSC	SRVKLGTLR	DEG_APCC_DBOX_1	0.3056
p.R18L	ACH-000757	Lung Cancer	CCLE	SRVKLGTLR	DEG_APCC_DBOX_1	0.3056
p.R18L	A427	lung	COSMIC	SRVKLGTLR	DEG_APCC_DBOX_1	0.3056
p.R10Q	SIDM00343	Glioblastoma	GDSC	SRVKLGTLR	DEG_APCC_DBOX_1	0.7329
p.R10Q	LN-405	central_nervous_system	COSMIC	SRVKLGTLR	DEG_APCC_DBOX_1	0.7329

Drug responses associated with PTK2B mutations

Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
SIDM00592	HNSC\|head_and_neck	p.G414E (No)	GDSC	PF-562271	2.7412
SIDM00578	NB\|neuroblastoma	p.T842M (No)	GDSC	PF-562271	2.7645
SIDM00629	BRCA\|breast	p.C395Y (No)	GDSC	PF-562271	33.971
SIDM00179	SKCM\|melanoma	p.R548K (No)	GDSC	PF-562271	4.5636
SIDM00683	PRAD\|prostate	p.N772K (No)	GDSC	PF-562271	15.8783
SIDM00353	UNCLASSIFIED\|ovary	p.V608A (No)	GDSC	PF-562271	11.2894
SIDM01034	UNCLASSIFIED\|B_cell_leukemia	p.T708I (No)	GDSC	PF-562271	2.6191
SIDM00909	SKCM\|melanoma	p.G562R (No)	GDSC	PF-562271	0.9657
SIDM00139	LUSC\|lung_NSCLC_squamous_cell_carcinoma	p.G636R (No)	GDSC	PF-562271	5.1007
SIDM00622	GBM\|glioma	p.F201L (No)	GDSC	PF-562271	5.521
SIDM00388	UNCLASSIFIED\|B_cell_leukemia	p.A167T (No)	GDSC	PF-562271	6.0635
SIDM00521	SCLC\|lung_small_cell_carcinoma	p.A799S (No)	GDSC	PF-562271	53.0955
SIDM00294	SCLC\|lung_small_cell_carcinoma	p.R936L (No)	GDSC	PF-562271	1.6285
SIDM01045	UCEC\|endometrium	p.E101G (No)	GDSC	PF-562271	24.6526
SIDM01045	UCEC\|endometrium	p.N259S (No)	GDSC	PF-562271	24.6526
SIDM00333	UCEC\|endometrium	p.R572W (No)	GDSC	PF-562271	2.2974
SIDM00249	ESCA\|oesophagus	p.K956T (No)	GDSC	PF-562271	3.4476
SIDM00854	UNCLASSIFIED\|Burkitt_lymphoma	p.A951P (No)	GDSC	PF-562271	1.3827
SIDM00783	COREAD\|large_intestine	p.V637fs*22 (No)	GDSC	PF-562271	1.5455
SIDM00910	NB\|neuroblastoma	p.Q359E (No)	GDSC	PF-562271	1.2267
SIDM00596	UCEC\|endometrium	p.R643W (No)	GDSC	PF-562271	7.126
SIDM00596	UCEC\|endometrium	p.L946F (No)	GDSC	PF-562271	7.126
SIDM00613	LGG\|glioma	p.P645S (No)	GDSC	PF-562271	15.3412
SIDM01057	LAML\|acute_myeloid_leukaemia	p.T978M (No)	GDSC	PF-562271	5.6969
SIDM00888	MB\|medulloblastoma	p.P724S (No)	GDSC	PF-562271	8.145
SIDM01176	ALL\|lymphoblastic_leukemia	p.N883S (No)	GDSC	PF-562271	2.9346
SIDM00486	LUSC\|lung_NSCLC_squamous_cell_carcinoma	p.R671fs*165 (No)	GDSC	PF-562271	6.2587
SIDM00321	UNCLASSIFIED\|ovary	p.T409P (No)	GDSC	PF-562271	8.3336
SIDM00973	SKCM\|melanoma	p.K801M (No)	GDSC	PF-562271	3.3005
SIDM00201	UNCLASSIFIED\|ewings_sarcoma	p.V456I (No)	GDSC	PF-562271	2.9613
SIDM01145	STAD\|stomach	p.A294T (No)	GDSC	PF-562271	41.0491
SIDM00810	UNCLASSIFIED\|lung_NSCLC_not_specified	p.R18L (Yes)	GDSC	PF-562271	5.833
SIDM01205	DLBC\|B_cell_lymphoma	p.S9I (Yes)	GDSC	PF-562271	2.7667
SIDM00487	COREAD\|large_intestine	p.E496G (No)	GDSC	PF-562271	14.8394
SIDM00963	BRCA\|breast	p.S336L (No)	GDSC	PF-562271	58.7529
SIDM01008	DLBC\|B_cell_lymphoma	p.T4A (Yes)	GDSC	PF-562271	7.9999
SIDM00343	GBM\|glioma	p.R10Q (Yes)	GDSC	PF-562271	55.0879
SIDM00542	GBM\|glioma	p.R373L (No)	GDSC	PF-562271	25.2118
SIDM00120	PRAD\|prostate	p.M885L (No)	GDSC	PF-562271	1.8752
SIDM00541	COREAD\|large_intestine	p.E577K (No)	GDSC	PF-562271	23.6187
SIDM00046	LUAD\|lung_NSCLC_adenocarcinoma	p.N883S (No)	GDSC	PF-562271	7.4682
SIDM00230	SCLC\|lung_small_cell_carcinoma	p.G2R (Yes)	GDSC	PF-562271	13.0143
SIDM01259	ALL\|lymphoblastic_leukemia	p.V613M (No)	GDSC	PF-562271	12.1157
SIDM00291	SKCM\|melanoma	p.Y440D (No)	GDSC	PF-562271	4.7855
SIDM01146	STAD\|stomach	p.A294T (No)	GDSC	PF-562271	8.2826
SIDM00118	COREAD\|large_intestine	p.I807T (No)	GDSC	PF-562271	3.5879

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: SRVKLGTLR

Degron related mutations and impact score

Drug responses associated with PTK2B mutations

All proteins holding degron of SRVKLGTLR

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q14289	Protein-tyrosine kinase 2-beta	DEG_APCC_DBOX_1	9:17	SRVKLGTLR	APC,CDC20,FZR1	0.8131	More...