DegronMD

Uniprot ID: P28827

Source protein: Receptor-type tyrosine-protein phosphatase mu

Source gene: PTPRM

Class: DEG_APCC_DBOX_1

Location: 938:946

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8357

ASA_SCORE: 58.9222

COIL: 0.4774

CONS_SCORE: 0.651

DSS_SCORE: 0.3564

HELIX: 0.0098

FCONS_SCORE: 0.9921

RIG_SCORE: 0.8012

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G943R	TCGA-43-A475	LUSC	TCGA	SRVRLQTIE	DEG_APCC_DBOX_1	0.7568
p.H950N	TCGA-AA-A00N	COAD	TCGA	SRVRLQTIE	DEG_APCC_DBOX_1	0.2222
p.D929N	TCGA-AA-A010	COAD	TCGA	SRVRLQTIE	DEG_APCC_DBOX_1	0.5278
p.D929A	TCGA-CV-6948	HNSC	TCGA	SRVRLQTIE	DEG_APCC_DBOX_1	0.5278
p.R937T	TCGA-EA-A43B	CESC	TCGA	SRVRLQTIE	DEG_APCC_DBOX_1	0.3056
p.K932N	TCGA-GM-A2DL	BRCA	TCGA	SRVRLQTIE	DEG_APCC_DBOX_1	0.1667
p.I934V	DO223732	CESC	ICGC	SRVRLQTIE	DEG_APCC_DBOX_1	0.2222
p.V932L	DO229019	LICA	ICGC	SRVRLQTIE	DEG_APCC_DBOX_1	0.1667
p.G945V	DO37896	SKCM	ICGC	SRVRLQTIE	DEG_APCC_DBOX_1	0.7532
p.S952F	DO47584	SKCM	ICGC	SRVRLQTIE	DEG_APCC_DBOX_1	0.1667
p.I932M	DO47761	STAD	ICGC	SRVRLQTIE	DEG_APCC_DBOX_1	0.1667
p.S951T	SIDM00551	Esophageal Squamous Cell Carcinoma	GDSC	SRVRLQTIE	DEG_APCC_DBOX_1	0.1944
p.S951T	KYSE-220	oesophagus	COSMIC	SRVRLQTIE	DEG_APCC_DBOX_1	0.1944
p.I945V	ACH-000930	Breast Cancer	CCLE	SRVRLQTIE	DEG_APCC_DBOX_1	0.5965
p.I945V	HCC1569	breast	COSMIC	SRVRLQTIE	DEG_APCC_DBOX_1	0.5965
p.S938T	ACH-002263	Esophageal Cancer	CCLE	SRVRLQTIE	DEG_APCC_DBOX_1	0.6005
p.S938T	KYSE-220	oesophagus	COSMIC	SRVRLQTIE	DEG_APCC_DBOX_1	0.6005
p.T954A	GP5d	large_intestine	COSMIC	SRVRLQTIE	DEG_APCC_DBOX_1	0.1111
p.Y949C	EN	endometrium	COSMIC	SRVRLQTIE	DEG_APCC_DBOX_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P28827	Receptor-type tyrosine-protein phosphatase mu	DEG_APCC_DBOX_1	938:946	SRVRLQTIE	APC,CDC20,FZR1	0.8357	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons