DegronMD - P28827(PTPRM)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G943R	TCGA-43-A475	LUSC	TCGA	SRVRLQTIE	DEG_APCC_DBOX_1	938:946	Mutation altering degron motif	0.7568
p.H950N	TCGA-AA-A00N	COAD	TCGA	SRVRLQTIE	DEG_APCC_DBOX_1	938:946	Mutation rewiring degron network	0.2222
p.D929N	TCGA-AA-A010	COAD	TCGA	SRVRLQTIE	DEG_APCC_DBOX_1	938:946	Mutation blocking phosphorylation signal	0.5278
p.T336M	TCGA-CQ-5327	HNSC	TCGA	VDSTS	DEG_SPOP_SBC_1	333:337	Mutation altering degron motif	0.7423
p.D929A	TCGA-CV-6948	HNSC	TCGA	SRVRLQTIE	DEG_APCC_DBOX_1	938:946	Mutation blocking phosphorylation signal	0.5278
p.R937T	TCGA-EA-A43B	CESC	TCGA	SRVRLQTIE	DEG_APCC_DBOX_1	938:946	Mutation rewiring degron network	0.3056
p.K932N	TCGA-GM-A2DL	BRCA	TCGA	SRVRLQTIE	DEG_APCC_DBOX_1	938:946	Mutation rewiring degron network	0.1667
p.I934V	DO223732	CESC	ICGC	SRVRLQTIE	DEG_APCC_DBOX_1	938:946	Mutation rewiring degron network	0.2222
p.R347H	DO9530	COAD	ICGC	VDSTS	DEG_SPOP_SBC_1	333:337	Mutation rewiring degron network	0.0556
p.G330E	DO222762	COCA	ICGC	VDSTS	DEG_SPOP_SBC_1	333:337	Mutation rewiring degron network	0.25
p.G330R	DO234318	ESAD	ICGC	VDSTS	DEG_SPOP_SBC_1	333:337	Mutation rewiring degron network	0.25
p.Y343C	DO233271	GACA	ICGC	VDSTS	DEG_SPOP_SBC_1	333:337	Mutation rewiring degron network	0.1667
p.E339Q	DO15390	HNSC	ICGC	VDSTS	DEG_SPOP_SBC_1	333:337	Mutation rewiring degron network	0.2778
p.V932L	DO229019	LICA	ICGC	SRVRLQTIE	DEG_APCC_DBOX_1	938:946	Mutation rewiring degron network	0.1667
p.P342L	DO45390	LUAD	ICGC	VDSTS	DEG_SPOP_SBC_1	333:337	Mutation rewiring degron network	0.1944
p.S347F	DO46327	OV	ICGC	VDSTS	DEG_SPOP_SBC_1	333:337	Mutation rewiring degron network	0.0556
p.G945V	DO37896	SKCM	ICGC	SRVRLQTIE	DEG_APCC_DBOX_1	938:946	Mutation altering degron motif	0.7532
p.R337S	DO37847	SKCM	ICGC	VDSTS	DEG_SPOP_SBC_1	333:337	Mutation altering degron motif	0.7427
p.S952F	DO47584	SKCM	ICGC	SRVRLQTIE	DEG_APCC_DBOX_1	938:946	Mutation rewiring degron network	0.1667
p.E339K	DO38431	STAD	ICGC	VDSTS	DEG_SPOP_SBC_1	333:337	Mutation rewiring degron network	0.2778
p.E339K	SCC90	upper aerodigestive tract	COSMIC	VDSTS	DEG_SPOP_SBC_1	333:337	Mutation rewiring degron network	0.2778
p.I932M	DO47761	STAD	ICGC	SRVRLQTIE	DEG_APCC_DBOX_1	938:946	Mutation rewiring degron network	0.1667
p.Q333R	DO41331	UCEC	ICGC	VDSTS	DEG_SPOP_SBC_1	333:337	Mutation altering degron motif	0.7329
p.S951T	SIDM00551	Esophageal Squamous Cell Carcinoma	GDSC	SRVRLQTIE	DEG_APCC_DBOX_1	938:946	Mutation rewiring degron network	0.1944
p.S951T	KYSE-220	oesophagus	COSMIC	SRVRLQTIE	DEG_APCC_DBOX_1	938:946	Mutation rewiring degron network	0.1944
p.L343I	ACH-000436	Myeloma	CCLE	VDSTS	DEG_SPOP_SBC_1	333:337	Mutation rewiring degron network	0.1667
p.I945V	ACH-000930	Breast Cancer	CCLE	SRVRLQTIE	DEG_APCC_DBOX_1	938:946	Mutation altering degron motif	0.5965
p.I945V	HCC1569	breast	COSMIC	SRVRLQTIE	DEG_APCC_DBOX_1	938:946	Mutation altering degron motif	0.5965
p.S324G	ACH-000990	Endometrial/Uterine Cancer	CCLE	VDSTS	DEG_SPOP_SBC_1	333:337	Mutation rewiring degron network	0.0833
p.S938T	ACH-002263	Esophageal Cancer	CCLE	SRVRLQTIE	DEG_APCC_DBOX_1	938:946	Mutation altering degron motif	0.6005
p.S938T	KYSE-220	oesophagus	COSMIC	SRVRLQTIE	DEG_APCC_DBOX_1	938:946	Mutation altering degron motif	0.6005
p.T954A	GP5d	large intestine	COSMIC	SRVRLQTIE	DEG_APCC_DBOX_1	938:946	Mutation rewiring degron network	0.1111
p.Y949C	EN	endometrium	COSMIC	SRVRLQTIE	DEG_APCC_DBOX_1	938:946	Mutation rewiring degron network	0.25

Kaplan plot for PTPRM in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PTPRM

UniProt ID: P28827

Entrez ID: 5797

Protein name: Receptor-type tyrosine-protein phosphatase mu (Protein-tyrosine phosphatase mu) (R-PTP-mu) (EC 3.1.3.48)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PTPRM in