DegronMD

Uniprot ID: P28827

Source protein: Receptor-type tyrosine-protein phosphatase mu

Source gene: PTPRM

Class: DEG_SPOP_SBC_1

Location: 333:337

E3 ligase: SPOP

DEGRON score: 0.7069

ASA_SCORE: 64.4

COIL: 0.5612

CONS_SCORE: 0.5545

DSS_SCORE: 0.4784

HELIX: 0.0168

FCONS_SCORE: 0.9794

RIG_SCORE: 0.7371

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T336M	TCGA-CQ-5327	HNSC	TCGA	VDSTS	DEG_SPOP_SBC_1	0.7423
p.R347H	DO9530	COAD	ICGC	VDSTS	DEG_SPOP_SBC_1	0.0556
p.G330E	DO222762	COCA	ICGC	VDSTS	DEG_SPOP_SBC_1	0.25
p.G330R	DO234318	ESAD	ICGC	VDSTS	DEG_SPOP_SBC_1	0.25
p.Y343C	DO233271	GACA	ICGC	VDSTS	DEG_SPOP_SBC_1	0.1667
p.E339Q	DO15390	HNSC	ICGC	VDSTS	DEG_SPOP_SBC_1	0.2778
p.P342L	DO45390	LUAD	ICGC	VDSTS	DEG_SPOP_SBC_1	0.1944
p.S347F	DO46327	OV	ICGC	VDSTS	DEG_SPOP_SBC_1	0.0556
p.R337S	DO37847	SKCM	ICGC	VDSTS	DEG_SPOP_SBC_1	0.7427
p.E339K	DO38431	STAD	ICGC	VDSTS	DEG_SPOP_SBC_1	0.2778
p.E339K	SCC90	upper_aerodigestive_tract	COSMIC	VDSTS	DEG_SPOP_SBC_1	0.2778
p.Q333R	DO41331	UCEC	ICGC	VDSTS	DEG_SPOP_SBC_1	0.7329
p.L343I	ACH-000436	Myeloma	CCLE	VDSTS	DEG_SPOP_SBC_1	0.1667
p.S324G	ACH-000990	Endometrial/Uterine Cancer	CCLE	VDSTS	DEG_SPOP_SBC_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P28827	Receptor-type tyrosine-protein phosphatase mu	DEG_SPOP_SBC_1	333:337	VDSTS	SPOP	0.7069	More...
Q9BYW2	Histone-lysine N-methyltransferase SETD2	DEG_SPOP_SBC_1	1168:1172	VDSTS	SPOP	0.9962	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons