DegronMD

Uniprot ID: Q9BYW2

Source protein: Histone-lysine N-methyltransferase SETD2

Source gene: SETD2

Class: DEG_SPOP_SBC_1

Location: 1168:1172

E3 ligase: SPOP

DEGRON score: 0.9962

ASA_SCORE: 67.12

COIL: 0.7898

CONS_SCORE: 0.3509

DSS_SCORE: 0.7534

HELIX: 0.0636

FCONS_SCORE: 1.1472

RIG_SCORE: 0.5477

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D1175Y	TCGA-EO-A22R	UCEC	TCGA	VDSTS	DEG_SPOP_SBC_1	0.25
p.D1175Y	DO42713	UCEC	ICGC	VDSTS	DEG_SPOP_SBC_1	0.25
p.Q1164H	TCGA-EY-A1GU	UCEC	TCGA	VDSTS	DEG_SPOP_SBC_1	0.2222
p.Q1164H	DO41518	UCEC	ICGC	VDSTS	DEG_SPOP_SBC_1	0.2222
p.G1182D	DO222765	COCA	ICGC	VDSTS	DEG_SPOP_SBC_1	0.0556
p.P1180T	DO228976	LICA	ICGC	VDSTS	DEG_SPOP_SBC_1	0.1111
p.P1158T	DO229045	LICA	ICGC	VDSTS	DEG_SPOP_SBC_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P28827	Receptor-type tyrosine-protein phosphatase mu	DEG_SPOP_SBC_1	333:337	VDSTS	SPOP	0.7069	More...
Q9BYW2	Histone-lysine N-methyltransferase SETD2	DEG_SPOP_SBC_1	1168:1172	VDSTS	SPOP	0.9962	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons