DegronMD

Uniprot ID: Q9UJL9

Source protein: Zinc finger protein 69 homolog B

Source gene: ZFP69B

Class: DEG_APCC_DBOX_1

Location: 59:67

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6363

ASA_SCORE: 72.8

COIL: 0.7226

CONS_SCORE: 0.6441

DSS_SCORE: 0.4191

HELIX: 0.1828

FCONS_SCORE: 0.9102

RIG_SCORE: 0.7498

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S59I	TCGA-26-6173	GBM	TCGA	SRVTLGSLT	DEG_APCC_DBOX_1	0.623
p.S59I	DO13827	GBM	ICGC	SRVTLGSLT	DEG_APCC_DBOX_1	0.623
p.G54S	TCGA-AJ-A3EK	UCEC	TCGA	SRVTLGSLT	DEG_APCC_DBOX_1	0.1944
p.G54S	DO41584	UCEC	ICGC	SRVTLGSLT	DEG_APCC_DBOX_1	0.1944
p.E55K	DO225208	BRCA	ICGC	SRVTLGSLT	DEG_APCC_DBOX_1	0.2222
p.I51V	DO8938	COAD	ICGC	SRVTLGSLT	DEG_APCC_DBOX_1	0.1111
p.S56R	DO50450	ESAD	ICGC	SRVTLGSLT	DEG_APCC_DBOX_1	0.25
p.S56R	DO50343	ESAD	ICGC	SRVTLGSLT	DEG_APCC_DBOX_1	0.25
p.G58E	DO233150	GACA	ICGC	SRVTLGSLT	DEG_APCC_DBOX_1	0.3056
p.G68V	DO228938	LICA	ICGC	SRVTLGSLT	DEG_APCC_DBOX_1	0.3056
p.A49S	DO229006	LICA	ICGC	SRVTLGSLT	DEG_APCC_DBOX_1	0.0556
p.F74Y	DO51276	SKCM	ICGC	SRVTLGSLT	DEG_APCC_DBOX_1	0.1389
p.M70T	DO38288	STAD	ICGC	SRVTLGSLT	DEG_APCC_DBOX_1	0.25
p.E58Q	SIDM00747	Non-Small Cell Lung Carcinoma	GDSC	SRVTLGSLT	DEG_APCC_DBOX_1	0.3056
p.E58Q	ACH-000744	Lung Cancer	CCLE	SRVTLGSLT	DEG_APCC_DBOX_1	0.3056
p.E58Q	NCI-H1623	lung	COSMIC	SRVTLGSLT	DEG_APCC_DBOX_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UJL9	Zinc finger protein 69 homolog B	DEG_APCC_DBOX_1	59:67	SRVTLGSLT	APC,CDC20,FZR1	0.6363	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons