DegronMD

Uniprot ID: Q8NEL0

Source protein: Coiled-coil domain-containing protein 54

Source gene: CCDC54

Class: DEG_COP1_1

Location: 191:201

E3 ligase: COP1

DEGRON score: 0.986

ASA_SCORE: 79.2455

COIL: 0.8372

CONS_SCORE: 0.6407

DSS_SCORE: 0.5906

HELIX: 0.0637

FCONS_SCORE: 1.4104

RIG_SCORE: 0.6409

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S204Y	TCGA-06-5416	GBM	TCGA	SSAEPEKVPSY	DEG_COP1_1	0.25
p.S204Y	DO10880	GBM	ICGC	SSAEPEKVPSY	DEG_COP1_1	0.25
p.S204Y	SIDM00511	Small Cell Lung Carcinoma	GDSC	SSAEPEKVPSY	DEG_COP1_1	0.25
p.S204Y	ACH-000257	Lung Cancer	CCLE	SSAEPEKVPSY	DEG_COP1_1	0.25
p.S204Y	COR-L279	lung	COSMIC	SSAEPEKVPSY	DEG_COP1_1	0.25
p.T205I	TCGA-2G-AAGM	TGCT	TCGA	SSAEPEKVPSY	DEG_COP1_1	0.2222
p.D206A	TCGA-2Y-A9GW	LIHC	TCGA	SSAEPEKVPSY	DEG_COP1_1	0.1944
p.D206A	DO219511	LIHC	ICGC	SSAEPEKVPSY	DEG_COP1_1	0.1944
p.D206A	SIDM00422	Hodgkin's Lymphoma	GDSC	SSAEPEKVPSY	DEG_COP1_1	0.1944
p.D206A	ACH-001203	Lymphoma	CCLE	SSAEPEKVPSY	DEG_COP1_1	0.1944
p.D206A	SUP-HD1	haematopoietic_and_lymphoid_tissue	COSMIC	SSAEPEKVPSY	DEG_COP1_1	0.1944
p.P202T	TCGA-CK-5916	COAD	TCGA	SSAEPEKVPSY	DEG_COP1_1	0.3056
p.P202T	DO8786	COAD	ICGC	SSAEPEKVPSY	DEG_COP1_1	0.3056
p.L208F	TCGA-D3-A8GB	SKCM	TCGA	SSAEPEKVPSY	DEG_COP1_1	0.1389
p.L208F	DO50280	SKCM	ICGC	SSAEPEKVPSY	DEG_COP1_1	0.1389
p.S192L	TCGA-GU-AATP	BLCA	TCGA	SSAEPEKVPSY	DEG_COP1_1	0.7667
p.S192L	DO51894	BLCA	ICGC	SSAEPEKVPSY	DEG_COP1_1	0.7667
p.S185A	TCGA-K4-A6FZ	BLCA	TCGA	SSAEPEKVPSY	DEG_COP1_1	0.1667
p.S185A	DO44045	BLCA	ICGC	SSAEPEKVPSY	DEG_COP1_1	0.1667
p.T182A	TCGA-VQ-A8P2	STAD	TCGA	SSAEPEKVPSY	DEG_COP1_1	0.5278
p.T182A	DO51761	STAD	ICGC	SSAEPEKVPSY	DEG_COP1_1	0.5278
p.P202S	DO222595	MELA	ICGC	SSAEPEKVPSY	DEG_COP1_1	0.3056
p.P195T	SIDM02033	Colorectal Carcinoma	GDSC	SSAEPEKVPSY	DEG_COP1_1	0.5919
p.P199L	SIDM01039	Other Solid Cancers	GDSC	SSAEPEKVPSY	DEG_COP1_1	0.7582
p.E209D	SIDM01100	Neuroblastoma	GDSC	SSAEPEKVPSY	DEG_COP1_1	0.1111
p.E209D	ACH-000366	Neuroblastoma	CCLE	SSAEPEKVPSY	DEG_COP1_1	0.1111
p.E209D	SK-N-DZ	autonomic_ganglia	COSMIC	SSAEPEKVPSY	DEG_COP1_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8NEL0	Coiled-coil domain-containing protein 54	DEG_COP1_1	191:201	SSAEPEKVPSY	COP1	0.986	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: SSAEPEKVPSY

Degron related mutations and impact score

Drug responses associated with CCDC54 mutations

All proteins holding degron of SSAEPEKVPSY