DegronMD - Q8NEL0(CCDC54)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S204Y	TCGA-06-5416	GBM	TCGA	SSAEPEKVPSY	DEG_COP1_1	191:201	Mutation rewiring degron network	0.25
p.S204Y	DO10880	GBM	ICGC	SSAEPEKVPSY	DEG_COP1_1	191:201	Mutation rewiring degron network	0.25
p.S204Y	SIDM00511	Small Cell Lung Carcinoma	GDSC	SSAEPEKVPSY	DEG_COP1_1	191:201	Mutation rewiring degron network	0.25
p.S204Y	ACH-000257	Lung Cancer	CCLE	SSAEPEKVPSY	DEG_COP1_1	191:201	Mutation rewiring degron network	0.25
p.S204Y	COR-L279	lung	COSMIC	SSAEPEKVPSY	DEG_COP1_1	191:201	Mutation rewiring degron network	0.25
p.T205I	TCGA-2G-AAGM	TGCT	TCGA	SSAEPEKVPSY	DEG_COP1_1	191:201	Mutation rewiring degron network	0.2222
p.D206A	TCGA-2Y-A9GW	LIHC	TCGA	SSAEPEKVPSY	DEG_COP1_1	191:201	Mutation rewiring degron network	0.1944
p.D206A	DO219511	LIHC	ICGC	SSAEPEKVPSY	DEG_COP1_1	191:201	Mutation rewiring degron network	0.1944
p.D206A	SIDM00422	Hodgkin's Lymphoma	GDSC	SSAEPEKVPSY	DEG_COP1_1	191:201	Mutation rewiring degron network	0.1944
p.D206A	ACH-001203	Lymphoma	CCLE	SSAEPEKVPSY	DEG_COP1_1	191:201	Mutation rewiring degron network	0.1944
p.D206A	SUP-HD1	haematopoietic and lymphoid tissue	COSMIC	SSAEPEKVPSY	DEG_COP1_1	191:201	Mutation rewiring degron network	0.1944
p.S27Y	TCGA-44-2657	LUAD	TCGA	VRQSLKNVY	DEG_APCC_DBOX_1	24:32	Mutation altering degron motif	0.6009
p.S27Y	DO25020	LUAD	ICGC	VRQSLKNVY	DEG_APCC_DBOX_1	24:32	Mutation altering degron motif	0.6009
p.M16K	TCGA-44-5644	LUAD	TCGA	VRQSLKNVY	DEG_APCC_DBOX_1	24:32	Mutation rewiring degron network	0.1111
p.M16K	DO25153	LUAD	ICGC	VRQSLKNVY	DEG_APCC_DBOX_1	24:32	Mutation rewiring degron network	0.1111
p.R14W	TCGA-55-7727	LUAD	TCGA	VRQSLKNVY	DEG_APCC_DBOX_1	24:32	Mutation rewiring degron network	0.0556
p.R14W	DO24297	LUAD	ICGC	VRQSLKNVY	DEG_APCC_DBOX_1	24:32	Mutation rewiring degron network	0.0556
p.M16I	TCGA-63-A5MS	LUSC	TCGA	VRQSLKNVY	DEG_APCC_DBOX_1	24:32	Mutation rewiring degron network	0.1111
p.M16I	DO219161	LUSC	ICGC	VRQSLKNVY	DEG_APCC_DBOX_1	24:32	Mutation rewiring degron network	0.1111
p.Q26H	TCGA-A8-A09B	BRCA	TCGA	VRQSLKNVY	DEG_APCC_DBOX_1	24:32	Mutation altering degron motif	0.647
p.Q26H	DO1653	BRCA	ICGC	VRQSLKNVY	DEG_APCC_DBOX_1	24:32	Mutation altering degron motif	0.647
p.P202T	TCGA-CK-5916	COAD	TCGA	SSAEPEKVPSY	DEG_COP1_1	191:201	Mutation rewiring degron network	0.3056
p.P202T	DO8786	COAD	ICGC	SSAEPEKVPSY	DEG_COP1_1	191:201	Mutation rewiring degron network	0.3056
p.L208F	TCGA-D3-A8GB	SKCM	TCGA	SSAEPEKVPSY	DEG_COP1_1	191:201	Mutation rewiring degron network	0.1389
p.L208F	DO50280	SKCM	ICGC	SSAEPEKVPSY	DEG_COP1_1	191:201	Mutation rewiring degron network	0.1389
p.R38W	TCGA-EE-A2MR	SKCM	TCGA	VRQSLKNVY	DEG_APCC_DBOX_1	24:32	Mutation rewiring degron network	0.1667
p.R38W	TCGA-EO-A22X	UCEC	TCGA	VRQSLKNVY	DEG_APCC_DBOX_1	24:32	Mutation rewiring degron network	0.1667
p.R38W	DO37819	SKCM	ICGC	VRQSLKNVY	DEG_APCC_DBOX_1	24:32	Mutation rewiring degron network	0.1667
p.R38W	DO43907	UCEC	ICGC	VRQSLKNVY	DEG_APCC_DBOX_1	24:32	Mutation rewiring degron network	0.1667
p.S192L	TCGA-GU-AATP	BLCA	TCGA	SSAEPEKVPSY	DEG_COP1_1	191:201	Mutation altering degron motif	0.7667
p.S192L	DO51894	BLCA	ICGC	SSAEPEKVPSY	DEG_COP1_1	191:201	Mutation altering degron motif	0.7667
p.S19L	TCGA-K4-A54R	BLCA	TCGA	VRQSLKNVY	DEG_APCC_DBOX_1	24:32	Mutation rewiring degron network	0.1944
p.S19L	DO48611	BLCA	ICGC	VRQSLKNVY	DEG_APCC_DBOX_1	24:32	Mutation rewiring degron network	0.1944
p.S185A	TCGA-K4-A6FZ	BLCA	TCGA	SSAEPEKVPSY	DEG_COP1_1	191:201	Mutation rewiring degron network	0.1667
p.S185A	DO44045	BLCA	ICGC	SSAEPEKVPSY	DEG_COP1_1	191:201	Mutation rewiring degron network	0.1667
p.T182A	TCGA-VQ-A8P2	STAD	TCGA	SSAEPEKVPSY	DEG_COP1_1	191:201	Mutation blocking phosphorylation signal	0.5278
p.T182A	DO51761	STAD	ICGC	SSAEPEKVPSY	DEG_COP1_1	191:201	Mutation blocking phosphorylation signal	0.5278
p.R38Q	DO229010	COCA	ICGC	VRQSLKNVY	DEG_APCC_DBOX_1	24:32	Mutation rewiring degron network	0.1667
p.R38Q	DO229013	COCA	ICGC	VRQSLKNVY	DEG_APCC_DBOX_1	24:32	Mutation rewiring degron network	0.1667
p.R38Q	DO229016	COCA	ICGC	VRQSLKNVY	DEG_APCC_DBOX_1	24:32	Mutation rewiring degron network	0.1667
p.R38Q	DO229003	COCA	ICGC	VRQSLKNVY	DEG_APCC_DBOX_1	24:32	Mutation rewiring degron network	0.1667
p.R38Q	DO229005	COCA	ICGC	VRQSLKNVY	DEG_APCC_DBOX_1	24:32	Mutation rewiring degron network	0.1667
p.H33Q	DO228205	LICA	ICGC	VRQSLKNVY	DEG_APCC_DBOX_1	24:32	Mutation rewiring degron network	0.3056
p.Q15H	DO220889	MELA	ICGC	VRQSLKNVY	DEG_APCC_DBOX_1	24:32	Mutation rewiring degron network	0.0833
p.P202S	DO222595	MELA	ICGC	SSAEPEKVPSY	DEG_COP1_1	191:201	Mutation rewiring degron network	0.3056
p.P195T	SIDM02033	Colorectal Carcinoma	GDSC	SSAEPEKVPSY	DEG_COP1_1	191:201	Mutation altering degron motif	0.5919
p.S27P	SIDM00507	Other Solid Cancers	GDSC	VRQSLKNVY	DEG_APCC_DBOX_1	24:32	Mutation altering degron motif	0.5641
p.S27P	ACH-001490	Lung Cancer	CCLE	VRQSLKNVY	DEG_APCC_DBOX_1	24:32	Mutation altering degron motif	0.5641
p.S27P	COR-L321	NS	COSMIC	VRQSLKNVY	DEG_APCC_DBOX_1	24:32	Mutation altering degron motif	0.5641
p.P199L	SIDM01039	Other Solid Cancers	GDSC	SSAEPEKVPSY	DEG_COP1_1	191:201	Mutation altering degron motif	0.7582
p.E209D	SIDM01100	Neuroblastoma	GDSC	SSAEPEKVPSY	DEG_COP1_1	191:201	Mutation rewiring degron network	0.1111
p.E209D	ACH-000366	Neuroblastoma	CCLE	SSAEPEKVPSY	DEG_COP1_1	191:201	Mutation rewiring degron network	0.1111
p.E209D	SK-N-DZ	autonomic ganglia	COSMIC	SSAEPEKVPSY	DEG_COP1_1	191:201	Mutation rewiring degron network	0.1111
p.V31A	ACH-001061	Colon/Colorectal Cancer	CCLE	VRQSLKNVY	DEG_APCC_DBOX_1	24:32	Mutation altering degron motif	0.6936

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CCDC54

UniProt ID: Q8NEL0

Entrez ID: 84692

Protein name: Coiled-coil domain-containing protein 54 (Testis development protein NYD-SP17)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CCDC54 in