DegronMD

Uniprot ID: Q8NEL0

Source protein: Coiled-coil domain-containing protein 54

Source gene: CCDC54

Class: DEG_APCC_DBOX_1

Location: 24:32

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8122

ASA_SCORE: 84.9889

COIL: 0.3628

CONS_SCORE: 0.6636

DSS_SCORE: 0.326

HELIX: 0.6049

FCONS_SCORE: 1.1294

RIG_SCORE: 0.7856

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S27Y	TCGA-44-2657	LUAD	TCGA	VRQSLKNVY	DEG_APCC_DBOX_1	0.6009
p.S27Y	DO25020	LUAD	ICGC	VRQSLKNVY	DEG_APCC_DBOX_1	0.6009
p.M16K	TCGA-44-5644	LUAD	TCGA	VRQSLKNVY	DEG_APCC_DBOX_1	0.1111
p.M16K	DO25153	LUAD	ICGC	VRQSLKNVY	DEG_APCC_DBOX_1	0.1111
p.R14W	TCGA-55-7727	LUAD	TCGA	VRQSLKNVY	DEG_APCC_DBOX_1	0.0556
p.R14W	DO24297	LUAD	ICGC	VRQSLKNVY	DEG_APCC_DBOX_1	0.0556
p.M16I	TCGA-63-A5MS	LUSC	TCGA	VRQSLKNVY	DEG_APCC_DBOX_1	0.1111
p.M16I	DO219161	LUSC	ICGC	VRQSLKNVY	DEG_APCC_DBOX_1	0.1111
p.Q26H	TCGA-A8-A09B	BRCA	TCGA	VRQSLKNVY	DEG_APCC_DBOX_1	0.647
p.Q26H	DO1653	BRCA	ICGC	VRQSLKNVY	DEG_APCC_DBOX_1	0.647
p.R38W	TCGA-EE-A2MR	SKCM	TCGA	VRQSLKNVY	DEG_APCC_DBOX_1	0.1667
p.R38W	TCGA-EO-A22X	UCEC	TCGA	VRQSLKNVY	DEG_APCC_DBOX_1	0.1667
p.R38W	DO37819	SKCM	ICGC	VRQSLKNVY	DEG_APCC_DBOX_1	0.1667
p.R38W	DO43907	UCEC	ICGC	VRQSLKNVY	DEG_APCC_DBOX_1	0.1667
p.S19L	TCGA-K4-A54R	BLCA	TCGA	VRQSLKNVY	DEG_APCC_DBOX_1	0.1944
p.S19L	DO48611	BLCA	ICGC	VRQSLKNVY	DEG_APCC_DBOX_1	0.1944
p.R38Q	DO229010	COCA	ICGC	VRQSLKNVY	DEG_APCC_DBOX_1	0.1667
p.R38Q	DO229013	COCA	ICGC	VRQSLKNVY	DEG_APCC_DBOX_1	0.1667
p.R38Q	DO229016	COCA	ICGC	VRQSLKNVY	DEG_APCC_DBOX_1	0.1667
p.R38Q	DO229003	COCA	ICGC	VRQSLKNVY	DEG_APCC_DBOX_1	0.1667
p.R38Q	DO229005	COCA	ICGC	VRQSLKNVY	DEG_APCC_DBOX_1	0.1667
p.H33Q	DO228205	LICA	ICGC	VRQSLKNVY	DEG_APCC_DBOX_1	0.3056
p.Q15H	DO220889	MELA	ICGC	VRQSLKNVY	DEG_APCC_DBOX_1	0.0833
p.S27P	SIDM00507	Other Solid Cancers	GDSC	VRQSLKNVY	DEG_APCC_DBOX_1	0.5641
p.S27P	ACH-001490	Lung Cancer	CCLE	VRQSLKNVY	DEG_APCC_DBOX_1	0.5641
p.S27P	COR-L321	NS	COSMIC	VRQSLKNVY	DEG_APCC_DBOX_1	0.5641
p.V31A	ACH-001061	Colon/Colorectal Cancer	CCLE	VRQSLKNVY	DEG_APCC_DBOX_1	0.6936

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8NEL0	Coiled-coil domain-containing protein 54	DEG_APCC_DBOX_1	24:32	VRQSLKNVY	APC,CDC20,FZR1	0.8122	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VRQSLKNVY

Degron related mutations and impact score

Drug responses associated with CCDC54 mutations

All proteins holding degron of VRQSLKNVY