DegronMD

Uniprot ID: Q9H4B4

Source protein: Serine/threonine-protein kinase PLK3

Source gene: PLK3

Class: DEG_COP1_1

Location: 326:334

E3 ligase: COP1

DEGRON score: 0.9819

ASA_SCORE: 65.0667

COIL: 0.7738

CONS_SCORE: 0.3243

DSS_SCORE: 0.4158

HELIX: 0.1307

FCONS_SCORE: 0.8779

RIG_SCORE: 0.7832

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R322Q	TCGA-06-5416	GBM	TCGA	SSCVTVPDL	DEG_COP1_1	0.2222
p.R322Q	DO10880	GBM	ICGC	SSCVTVPDL	DEG_COP1_1	0.2222
p.V329M	TCGA-AA-3715	COAD	TCGA	SSCVTVPDL	DEG_COP1_1	0.6097
p.V329M	DO8018	COAD	ICGC	SSCVTVPDL	DEG_COP1_1	0.6097
p.Y318H	TCGA-AA-3947	COAD	TCGA	SSCVTVPDL	DEG_COP1_1	0.1111
p.Y318H	DO8192	COAD	ICGC	SSCVTVPDL	DEG_COP1_1	0.1111
p.P324H	TCGA-EE-A29W	SKCM	TCGA	SSCVTVPDL	DEG_COP1_1	0.2778
p.P324H	TCGA-FS-A1ZR	SKCM	TCGA	SSCVTVPDL	DEG_COP1_1	0.2778
p.P324H	DO37651	SKCM	ICGC	SSCVTVPDL	DEG_COP1_1	0.2778
p.P324H	DO47658	SKCM	ICGC	SSCVTVPDL	DEG_COP1_1	0.2778
p.P336H	TCGA-EM-A22M	THCA	TCGA	SSCVTVPDL	DEG_COP1_1	0.2778
p.P336H	DO40387	THCA	ICGC	SSCVTVPDL	DEG_COP1_1	0.2778
p.D321N	TCGA-N6-A4VD	UCS	TCGA	SSCVTVPDL	DEG_COP1_1	0.1944
p.D321N	SIDM01943	Colorectal Carcinoma	GDSC	SSCVTVPDL	DEG_COP1_1	0.1944
p.I325M	TCGA-SY-A9G5	BLCA	TCGA	SSCVTVPDL	DEG_COP1_1	0.3056
p.I325M	DO51906	BLCA	ICGC	SSCVTVPDL	DEG_COP1_1	0.3056
p.P320L	DO220911	MELA	ICGC	SSCVTVPDL	DEG_COP1_1	0.1667

Drug responses associated with PLK3 mutations

Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
SIDM00951	LAML\|acute_myeloid_leukaemia	p.W151L (No)	GDSC	BI-2536	0.0205
SIDM00951	LAML\|acute_myeloid_leukaemia	p.W151L (No)	GDSC	NPK76-II-72-1	0.9643
SIDM00951	LAML\|acute_myeloid_leukaemia	p.W151L (No)	GDSC	PLK_6522	0.0096
SIDM00544	NB\|neuroblastoma	p.G475V (No)	GDSC	BI-2536	0.4706
SIDM00544	NB\|neuroblastoma	p.G475V (No)	GDSC	NPK76-II-72-1	14.7835
SIDM00544	NB\|neuroblastoma	p.G475V (No)	GDSC	PLK_6522	0.025
SIDM00433	ALL\|lymphoblastic_T_cell_leukaemia	p.C221Y (No)	GDSC	BI-2536	0.0278
SIDM00433	ALL\|lymphoblastic_T_cell_leukaemia	p.C221Y (No)	GDSC	NPK76-II-72-1	0.1416
SIDM00433	ALL\|lymphoblastic_T_cell_leukaemia	p.C221Y (No)	GDSC	PLK_6522	0.0067
SIDM01063	UNCLASSIFIED\|Hodgkin_lymphoma	p.G256E (No)	GDSC	BI-2536	0.048
SIDM01063	UNCLASSIFIED\|Hodgkin_lymphoma	p.G256E (No)	GDSC	NPK76-II-72-1	6.613
SIDM01063	UNCLASSIFIED\|Hodgkin_lymphoma	p.G256E (No)	GDSC	PLK_6522	0.0141
SIDM01051	UNCLASSIFIED\|ovary	p.N338fs*35 (Yes)	GDSC	NPK76-II-72-1	32.8392
SIDM01051	UNCLASSIFIED\|ovary	p.N338fs*35 (Yes)	GDSC	PLK_6522	0.1367
SIDM00683	PRAD\|prostate	p.C255Y (No)	GDSC	BI-2536	4.3027
SIDM00683	PRAD\|prostate	p.C255Y (No)	GDSC	NPK76-II-72-1	21.116
SIDM00683	PRAD\|prostate	p.C255Y (No)	GDSC	PLK_6522	0.0214
SIDM00901	UCEC\|endometrium	p.W463* (No)	GDSC	NPK76-II-72-1	12.5944
SIDM00901	UCEC\|endometrium	p.W463* (No)	GDSC	PLK_6522	0.034
SIDM00214	COREAD\|large_intestine	p.R377C (No)	GDSC	NPK76-II-72-1	5.083
SIDM00214	COREAD\|large_intestine	p.R377C (No)	GDSC	PLK_6522	0.0315
SIDM00958	LCML\|chronic_myeloid_leukaemia	p.D264N (No)	GDSC	PLK_6522	0.0206
SIDM00553	LAML\|leukemia	p.A453T (No)	GDSC	BI-2536	0.0476
SIDM00553	LAML\|leukemia	p.A453T (No)	GDSC	NPK76-II-72-1	10.4244
SIDM00553	LAML\|leukemia	p.A453T (No)	GDSC	PLK_6522	0.0241
SIDM00252	UNCLASSIFIED\|biliary_tract	p.R354K (No)	GDSC	BI-2536	0.0607
SIDM00252	UNCLASSIFIED\|biliary_tract	p.R354K (No)	GDSC	NPK76-II-72-1	121.1772
SIDM00252	UNCLASSIFIED\|biliary_tract	p.R354K (No)	GDSC	PLK_6522	0.1381
SIDM01045	UCEC\|endometrium	p.A486D (No)	GDSC	NPK76-II-72-1	46.6919
SIDM01045	UCEC\|endometrium	p.A486D (No)	GDSC	PLK_6522	0.7351
SIDM00946	ALL\|T_cell_leukemia	p.V427L (No)	GDSC	BI-2536	0.0309
SIDM00946	ALL\|T_cell_leukemia	p.V427L (No)	GDSC	NPK76-II-72-1	0.5338
SIDM00946	ALL\|T_cell_leukemia	p.V427L (No)	GDSC	PLK_6522	0.0076
SIDM00864	CESC\|cervix	p.R163L (No)	GDSC	NPK76-II-72-1	11.8127
SIDM00864	CESC\|cervix	p.R163L (No)	GDSC	PLK_6522	0.202
SIDM00602	STAD\|stomach	p.S126fs*74 (No)	GDSC	NPK76-II-72-1	19.118
SIDM00602	STAD\|stomach	p.S126fs*74 (No)	GDSC	PLK_6522	0.6452
SIDM01157	UNCLASSIFIED\|urogenital_system_other	p.A434S (No)	GDSC	BI-2536	0.0208
SIDM01157	UNCLASSIFIED\|urogenital_system_other	p.A434S (No)	GDSC	NPK76-II-72-1	1.6639
SIDM01157	UNCLASSIFIED\|urogenital_system_other	p.A434S (No)	GDSC	PLK_6522	0.0183
SIDM00999	BLCA\|bladder	p.W467C (No)	GDSC	NPK76-II-72-1	10.6481
SIDM00999	BLCA\|bladder	p.W467C (No)	GDSC	PLK_6522	0.0188
SIDM00951	LAML\|acute_myeloid_leukaemia	p.K356fs*17 (No)	GDSC	BI-2536	0.0205
SIDM00951	LAML\|acute_myeloid_leukaemia	p.K356fs*17 (No)	GDSC	NPK76-II-72-1	0.9643
SIDM00951	LAML\|acute_myeloid_leukaemia	p.K356fs*17 (No)	GDSC	PLK_6522	0.0096
SIDM00111	GBM\|glioma	p.T82A (No)	GDSC	NPK76-II-72-1	4.1522
SIDM00111	GBM\|glioma	p.T82A (No)	GDSC	PLK_6522	0.014
SIDM00205	UNCLASSIFIED\|ewings_sarcoma	p.G370S (No)	GDSC	BI-2536	0.0313
SIDM00205	UNCLASSIFIED\|ewings_sarcoma	p.G370S (No)	GDSC	NPK76-II-72-1	0.426
SIDM00205	UNCLASSIFIED\|ewings_sarcoma	p.G370S (No)	GDSC	PLK_6522	0.0059
SIDM00150	COREAD\|large_intestine	p.P101S (No)	GDSC	BI-2536	0.0143
SIDM00150	COREAD\|large_intestine	p.P101S (No)	GDSC	NPK76-II-72-1	14.5375
SIDM00150	COREAD\|large_intestine	p.P101S (No)	GDSC	PLK_6522	0.3194
SIDM00281	UNCLASSIFIED\|skin_other	p.S304C (No)	GDSC	BI-2536	0.0602
SIDM00281	UNCLASSIFIED\|skin_other	p.S304C (No)	GDSC	NPK76-II-72-1	35.1471
SIDM00281	UNCLASSIFIED\|skin_other	p.S304C (No)	GDSC	PLK_6522	0.1153
SIDM00281	UNCLASSIFIED\|skin_other	p.Q307H (No)	GDSC	BI-2536	0.0602
SIDM00281	UNCLASSIFIED\|skin_other	p.Q307H (No)	GDSC	NPK76-II-72-1	35.1471
SIDM00281	UNCLASSIFIED\|skin_other	p.Q307H (No)	GDSC	PLK_6522	0.1153
SIDM00574	LGG\|glioma	p.A437P (No)	GDSC	BI-2536	0.0349
SIDM00574	LGG\|glioma	p.A437P (No)	GDSC	NPK76-II-72-1	194.7173
SIDM00574	LGG\|glioma	p.A437P (No)	GDSC	PLK_6522	0.1952
SIDM00673	BRCA\|breast	p.T262M (No)	GDSC	NPK76-II-72-1	13.7553
SIDM00673	BRCA\|breast	p.T262M (No)	GDSC	PLK_6522	5.279
SIDM00673	BRCA\|breast	p.T262M (No)	GDSC	BI-2536	3.9861
SIDM00297	LUAD\|lung_NSCLC_adenocarcinoma	p.A456V (No)	GDSC	BI-2536	0.0081
SIDM00297	LUAD\|lung_NSCLC_adenocarcinoma	p.A456V (No)	GDSC	NPK76-II-72-1	1.8464
SIDM00297	LUAD\|lung_NSCLC_adenocarcinoma	p.A456V (No)	GDSC	PLK_6522	0.0143
SIDM00324	NB\|neuroblastoma	p.D264N (No)	GDSC	BI-2536	0.1456
SIDM00324	NB\|neuroblastoma	p.D264N (No)	GDSC	NPK76-II-72-1	3.7941
SIDM00324	NB\|neuroblastoma	p.D264N (No)	GDSC	PLK_6522	0.0844
SIDM01146	STAD\|stomach	p.N338fs*35 (Yes)	GDSC	BI-2536	1.96
SIDM01146	STAD\|stomach	p.N338fs*35 (Yes)	GDSC	NPK76-II-72-1	7.3361
SIDM01146	STAD\|stomach	p.N338fs*35 (Yes)	GDSC	PLK_6522	7.8576
SIDM00451	ALL\|lymphoblastic_T_cell_leukaemia	p.T268M (No)	GDSC	BI-2536	0.0224
SIDM00451	ALL\|lymphoblastic_T_cell_leukaemia	p.T268M (No)	GDSC	NPK76-II-72-1	0.5528
SIDM00451	ALL\|lymphoblastic_T_cell_leukaemia	p.T268M (No)	GDSC	PLK_6522	0.8422
SIDM00451	ALL\|lymphoblastic_T_cell_leukaemia	p.S611G (No)	GDSC	BI-2536	0.0224
SIDM00451	ALL\|lymphoblastic_T_cell_leukaemia	p.S611G (No)	GDSC	NPK76-II-72-1	0.5528
SIDM00451	ALL\|lymphoblastic_T_cell_leukaemia	p.S611G (No)	GDSC	PLK_6522	0.8422
SIDM00892	BRCA\|breast	p.Q103E (No)	GDSC	NPK76-II-72-1	376.384
SIDM00892	BRCA\|breast	p.Q103E (No)	GDSC	PLK_6522	9.8996
SIDM00892	BRCA\|breast	p.Q103E (No)	GDSC	BI-2536	18.254
SIDM01144	STAD\|stomach	p.R610H (No)	GDSC	BI-2536	0.1126
SIDM01144	STAD\|stomach	p.R610H (No)	GDSC	NPK76-II-72-1	229.5675
SIDM01144	STAD\|stomach	p.R610H (No)	GDSC	PLK_6522	0.0933

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: SSCVTVPDL

Degron related mutations and impact score

Drug responses associated with PLK3 mutations

All proteins holding degron of SSCVTVPDL

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9H4B4	Serine/threonine-protein kinase PLK3	DEG_COP1_1	326:334	SSCVTVPDL	COP1	0.9819	More...