DegronMD

Uniprot ID: Q9H4B4

Source protein: Serine/threonine-protein kinase PLK3

Source gene: PLK3

Class: DEG_COP1_1

Location: 326:334

E3 ligase: COP1

DEGRON score: 0.9819

ASA_SCORE: 65.0667

COIL: 0.7738

CONS_SCORE: 0.3243

DSS_SCORE: 0.4158

HELIX: 0.1307

FCONS_SCORE: 0.8779

RIG_SCORE: 0.7832

Degron related mutations and impact score

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V329M	TCGA-AA-3715	COAD	TCGA	SSCVTVPDL	DEG_COP1_1	0.6097
p.V329M	DO8018	COAD	ICGC	SSCVTVPDL	DEG_COP1_1	0.6097
p.I325M	TCGA-SY-A9G5	BLCA	TCGA	SSCVTVPDL	DEG_COP1_1	0.3056
p.I325M	DO51906	BLCA	ICGC	SSCVTVPDL	DEG_COP1_1	0.3056
p.P324H	TCGA-EE-A29W	SKCM	TCGA	SSCVTVPDL	DEG_COP1_1	0.2778
p.P324H	TCGA-FS-A1ZR	SKCM	TCGA	SSCVTVPDL	DEG_COP1_1	0.2778
p.P324H	DO37651	SKCM	ICGC	SSCVTVPDL	DEG_COP1_1	0.2778
p.P324H	DO47658	SKCM	ICGC	SSCVTVPDL	DEG_COP1_1	0.2778
p.P336H	TCGA-EM-A22M	THCA	TCGA	SSCVTVPDL	DEG_COP1_1	0.2778
p.P336H	DO40387	THCA	ICGC	SSCVTVPDL	DEG_COP1_1	0.2778
p.R322Q	TCGA-06-5416	GBM	TCGA	SSCVTVPDL	DEG_COP1_1	0.2222
p.R322Q	DO10880	GBM	ICGC	SSCVTVPDL	DEG_COP1_1	0.2222
p.D321N	TCGA-N6-A4VD	UCS	TCGA	SSCVTVPDL	DEG_COP1_1	0.1944
p.D321N	SIDM01943	Colorectal Carcinoma	GDSC	SSCVTVPDL	DEG_COP1_1	0.1944
p.P320L	DO220911	MELA	ICGC	SSCVTVPDL	DEG_COP1_1	0.1667
p.Y318H	TCGA-AA-3947	COAD	TCGA	SSCVTVPDL	DEG_COP1_1	0.1111
p.Y318H	DO8192	COAD	ICGC	SSCVTVPDL	DEG_COP1_1	0.1111

Showing 1 to 17 of 17 entries

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Drug responses associated with PLK3 mutations

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
SIDM00433	ALL\|lymphoblastic_T_cell_leukaemia	p.C221Y (No)	GDSC	BI-2536	0.0278
SIDM00433	ALL\|lymphoblastic_T_cell_leukaemia	p.C221Y (No)	GDSC	NPK76-II-72-1	0.1416
SIDM00433	ALL\|lymphoblastic_T_cell_leukaemia	p.C221Y (No)	GDSC	PLK_6522	0.0067
SIDM00451	ALL\|lymphoblastic_T_cell_leukaemia	p.T268M (No)	GDSC	BI-2536	0.0224
SIDM00451	ALL\|lymphoblastic_T_cell_leukaemia	p.T268M (No)	GDSC	NPK76-II-72-1	0.5528
SIDM00451	ALL\|lymphoblastic_T_cell_leukaemia	p.T268M (No)	GDSC	PLK_6522	0.8422
SIDM00451	ALL\|lymphoblastic_T_cell_leukaemia	p.S611G (No)	GDSC	BI-2536	0.0224
SIDM00451	ALL\|lymphoblastic_T_cell_leukaemia	p.S611G (No)	GDSC	NPK76-II-72-1	0.5528
SIDM00451	ALL\|lymphoblastic_T_cell_leukaemia	p.S611G (No)	GDSC	PLK_6522	0.8422
SIDM00946	ALL\|T_cell_leukemia	p.V427L (No)	GDSC	BI-2536	0.0309
SIDM00946	ALL\|T_cell_leukemia	p.V427L (No)	GDSC	NPK76-II-72-1	0.5338
SIDM00946	ALL\|T_cell_leukemia	p.V427L (No)	GDSC	PLK_6522	0.0076
SIDM00999	BLCA\|bladder	p.W467C (No)	GDSC	NPK76-II-72-1	10.6481
SIDM00999	BLCA\|bladder	p.W467C (No)	GDSC	PLK_6522	0.0188
SIDM00673	BRCA\|breast	p.T262M (No)	GDSC	NPK76-II-72-1	13.7553
SIDM00673	BRCA\|breast	p.T262M (No)	GDSC	PLK_6522	5.279
SIDM00673	BRCA\|breast	p.T262M (No)	GDSC	BI-2536	3.9861
SIDM00892	BRCA\|breast	p.Q103E (No)	GDSC	NPK76-II-72-1	376.384
SIDM00892	BRCA\|breast	p.Q103E (No)	GDSC	PLK_6522	9.8996
SIDM00892	BRCA\|breast	p.Q103E (No)	GDSC	BI-2536	18.254
SIDM00864	CESC\|cervix	p.R163L (No)	GDSC	NPK76-II-72-1	11.8127
SIDM00864	CESC\|cervix	p.R163L (No)	GDSC	PLK_6522	0.202
SIDM00214	COREAD\|large_intestine	p.R377C (No)	GDSC	NPK76-II-72-1	5.083
SIDM00214	COREAD\|large_intestine	p.R377C (No)	GDSC	PLK_6522	0.0315
SIDM00150	COREAD\|large_intestine	p.P101S (No)	GDSC	BI-2536	0.0143

Showing 1 to 25 of 86 entries

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All proteins holding degron of SSCVTVPDL

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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9H4B4	Serine/threonine-protein kinase PLK3	DEG_COP1_1	326:334	SSCVTVPDL	COP1	0.9819	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: SSCVTVPDL

Degron related mutations and impact score

Drug responses associated with PLK3 mutations

All proteins holding degron of SSCVTVPDL