DegronMD

Uniprot ID: Q7L4I2

Source protein: Arginine/serine-rich coiled-coil protein 2

Source gene: RSRC2

Class: DEG_Kelch_Keap1_1

Location: 104:109

E3 ligase: KEAP1

DEGRON score: 0.7753

ASA_SCORE: 107.05

COIL: 0.9242

CONS_SCORE: 0.4662

DSS_SCORE: 0.7334

HELIX: 0.0803

FCONS_SCORE: 0.9594

RIG_SCORE: 0.4936

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R114H	TCGA-AP-A1DV	UCEC	TCGA	SSENGE	DEG_Kelch_Keap1_1	0.1944
p.R114H	DO43186	UCEC	ICGC	SSENGE	DEG_Kelch_Keap1_1	0.1944
p.R114C	TCGA-FI-A2D6	UCEC	TCGA	SSENGE	DEG_Kelch_Keap1_1	0.1944
p.R114C	DO43867	UCEC	ICGC	SSENGE	DEG_Kelch_Keap1_1	0.1944
p.D96H	TCGA-ZF-AA53	BLCA	TCGA	SSENGE	DEG_Kelch_Keap1_1	0.1111
p.D96H	DO219096	BLCA	ICGC	SSENGE	DEG_Kelch_Keap1_1	0.1111
p.G108D	SIDM00846	Cervical Carcinoma	GDSC	SSENGE	DEG_Kelch_Keap1_1	0.7198
p.G108D	ACH-001086	Cervical Cancer	CCLE	SSENGE	DEG_Kelch_Keap1_1	0.7198
p.G108D	HeLa	cervix	COSMIC	SSENGE	DEG_Kelch_Keap1_1	0.7198

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q7L4I2	Arginine/serine-rich coiled-coil protein 2	DEG_Kelch_Keap1_1	104:109	SSENGE	KEAP1	0.7753	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons