DegronMD

Uniprot ID: Q8N7S6

Source protein: Uncharacterized protein ARIH2OS

Source gene: ARIH2OS

Class: DEG_COP1_1

Location: 94:102

E3 ligase: COP1

DEGRON score: 0.9989

ASA_SCORE: 77.3556

COIL: 0.8372

CONS_SCORE: 1

DSS_SCORE: 0.5103

HELIX: 0.1117

FCONS_SCORE: 1.0476

RIG_SCORE: 0.6887

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D86N	TCGA-C4-A0F1	BLCA	TCGA	SSRRVVPTA	DEG_COP1_1	0.1111
p.D86N	DO581	BLCA	ICGC	SSRRVVPTA	DEG_COP1_1	0.1111
p.E104K	TCGA-D3-A1Q5	SKCM	TCGA	SSRRVVPTA	DEG_COP1_1	0.2778
p.E104K	TCGA-ER-A2NC	SKCM	TCGA	SSRRVVPTA	DEG_COP1_1	0.2778
p.E104K	DO37827	SKCM	ICGC	SSRRVVPTA	DEG_COP1_1	0.2778
p.E104K	DO47318	SKCM	ICGC	SSRRVVPTA	DEG_COP1_1	0.2778
p.E104K	ACH-000812	Skin Cancer	CCLE	SSRRVVPTA	DEG_COP1_1	0.2778
p.E104K	COLO-783	skin	COSMIC	SSRRVVPTA	DEG_COP1_1	0.2778
p.P103T	TCGA-EB-A85I	SKCM	TCGA	SSRRVVPTA	DEG_COP1_1	0.3056
p.P103T	DO50296	SKCM	ICGC	SSRRVVPTA	DEG_COP1_1	0.3056
p.P103Q	TCGA-G7-6797	KIRP	TCGA	SSRRVVPTA	DEG_COP1_1	0.3056
p.P103Q	DO20917	KIRP	ICGC	SSRRVVPTA	DEG_COP1_1	0.3056
p.A87T	TCGA-ZF-A9R9	BLCA	TCGA	SSRRVVPTA	DEG_COP1_1	0.1389
p.A87T	DO219066	BLCA	ICGC	SSRRVVPTA	DEG_COP1_1	0.1389
p.A92T	DO225209	BRCA	ICGC	SSRRVVPTA	DEG_COP1_1	0.2778
p.P100S	ACH-000226	Lymphoma	CCLE	SSRRVVPTA	DEG_COP1_1	0.6752
p.P100S	SUP-M2	haematopoietic_and_lymphoid_tissue	COSMIC	SSRRVVPTA	DEG_COP1_1	0.6752
p.P100A	ACH-001818	Bone Cancer	CCLE	SSRRVVPTA	DEG_COP1_1	0.7503

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8N7S6	Uncharacterized protein ARIH2OS	DEG_COP1_1	94:102	SSRRVVPTA	COP1	0.9989	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons