DegronMD

Uniprot ID: Q6P3W7

Source protein: SCY1-like protein 2

Source gene: SCYL2

Class: DEG_COP1_1

Location: 743:752

E3 ligase: COP1

DEGRON score: 0.9986

ASA_SCORE: 75.65

COIL: 0.9277

CONS_SCORE: 0.2693

DSS_SCORE: 0.4194

HELIX: 0.0453

FCONS_SCORE: 0.8136

RIG_SCORE: 0.6855

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T745I	TCGA-23-2081	OV	TCGA	SSTFTSVPSM	DEG_COP1_1	0.7078
p.T745I	DO28681	OV	ICGC	SSTFTSVPSM	DEG_COP1_1	0.7078
p.S748F	TCGA-23-2081	OV	TCGA	SSTFTSVPSM	DEG_COP1_1	0.6871
p.S748F	TCGA-VQ-A8P2	STAD	TCGA	SSTFTSVPSM	DEG_COP1_1	0.6871
p.S748F	DO28681	OV	ICGC	SSTFTSVPSM	DEG_COP1_1	0.6871
p.S748F	DO51761	STAD	ICGC	SSTFTSVPSM	DEG_COP1_1	0.6871
p.S748Y	TCGA-A5-A0G1	UCEC	TCGA	SSTFTSVPSM	DEG_COP1_1	0.6009
p.S748Y	DO42472	UCEC	ICGC	SSTFTSVPSM	DEG_COP1_1	0.6009
p.I754T	TCGA-CJ-5672	KIRC	TCGA	SSTFTSVPSM	DEG_COP1_1	0.2778
p.I754T	DO17947	KIRC	ICGC	SSTFTSVPSM	DEG_COP1_1	0.2778
p.T745S	TCGA-T2-A6X0	HNSC	TCGA	SSTFTSVPSM	DEG_COP1_1	0.6005
p.T745S	DO219069	HNSC	ICGC	SSTFTSVPSM	DEG_COP1_1	0.6005
p.S759F	TCGA-X7-A8M5	THYM	TCGA	SSTFTSVPSM	DEG_COP1_1	0.5833
p.L733I	DO11776	GBM	ICGC	SSTFTSVPSM	DEG_COP1_1	0.0556
p.T745A	DO23544	LIRI	ICGC	SSTFTSVPSM	DEG_COP1_1	0.7139
p.S734Y	DO232761	PBCA	ICGC	SSTFTSVPSM	DEG_COP1_1	0.0833
p.V753F	SIDM00183	Small Cell Lung Carcinoma	GDSC	SSTFTSVPSM	DEG_COP1_1	0.3056
p.V753F	LB647-SCLC	lung	COSMIC	SSTFTSVPSM	DEG_COP1_1	0.3056
p.P754S	SIDM00126	Melanoma	GDSC	SSTFTSVPSM	DEG_COP1_1	0.2778
p.P754S	K2	skin	COSMIC	SSTFTSVPSM	DEG_COP1_1	0.2778
p.P750S	ACH-002147	Skin Cancer	CCLE	SSTFTSVPSM	DEG_COP1_1	0.6752
p.P750S	K2	skin	COSMIC	SSTFTSVPSM	DEG_COP1_1	0.6752
p.V749F	ACH-002154	Lung Cancer	CCLE	SSTFTSVPSM	DEG_COP1_1	0.7068
p.V749F	LB647-SCLC	lung	COSMIC	SSTFTSVPSM	DEG_COP1_1	0.7068

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6P3W7	SCY1-like protein 2	DEG_COP1_1	743:752	SSTFTSVPSM	COP1	0.9986	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons