DegronMD - Q6P3W7(SCYL2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.T745I	TCGA-23-2081	OV	TCGA	SSTFTSVPSM	DEG_COP1_1	743:752	Mutation altering degron motif	0.7078
p.T745I	DO28681	OV	ICGC	SSTFTSVPSM	DEG_COP1_1	743:752	Mutation altering degron motif	0.7078
p.S748F	TCGA-23-2081	OV	TCGA	SSTFTSVPSM	DEG_COP1_1	743:752	Mutation altering degron motif	0.6871
p.S748F	TCGA-VQ-A8P2	STAD	TCGA	SSTFTSVPSM	DEG_COP1_1	743:752	Mutation altering degron motif	0.6871
p.S748F	DO28681	OV	ICGC	SSTFTSVPSM	DEG_COP1_1	743:752	Mutation altering degron motif	0.6871
p.S748F	DO51761	STAD	ICGC	SSTFTSVPSM	DEG_COP1_1	743:752	Mutation altering degron motif	0.6871
p.S748Y	TCGA-A5-A0G1	UCEC	TCGA	SSTFTSVPSM	DEG_COP1_1	743:752	Mutation altering degron motif	0.6009
p.S748Y	DO42472	UCEC	ICGC	SSTFTSVPSM	DEG_COP1_1	743:752	Mutation altering degron motif	0.6009
p.P738T	TCGA-BF-A1Q0	SKCM	TCGA	VSTPKSS	DEG_SCF_FBW7_1	735:741	Mutation altering degron motif	0.7031
p.P738T	DO47374	SKCM	ICGC	VSTPKSS	DEG_SCF_FBW7_1	735:741	Mutation altering degron motif	0.7031
p.I754T	TCGA-CJ-5672	KIRC	TCGA	SSTFTSVPSM	DEG_COP1_1	743:752	Mutation rewiring degron network	0.2778
p.I754T	DO17947	KIRC	ICGC	SSTFTSVPSM	DEG_COP1_1	743:752	Mutation rewiring degron network	0.2778
p.T745S	TCGA-T2-A6X0	HNSC	TCGA	SSTFTSVPSM	DEG_COP1_1	743:752	Mutation altering degron motif	0.6005
p.T745S	DO219069	HNSC	ICGC	SSTFTSVPSM	DEG_COP1_1	743:752	Mutation altering degron motif	0.6005
p.S759F	TCGA-X7-A8M5	THYM	TCGA	SSTFTSVPSM	DEG_COP1_1	743:752	Mutation blocking phosphorylation signal	0.5833
p.T716S	DO228483	BRCA	ICGC	VHTPVAT	DEG_SCF_FBW7_1	706:712	Mutation rewiring degron network	0.2222
p.T716S	DO229013	COCA	ICGC	VHTPVAT	DEG_SCF_FBW7_1	706:712	Mutation rewiring degron network	0.2222
p.T716S	DO230659	LAML	ICGC	VHTPVAT	DEG_SCF_FBW7_1	706:712	Mutation rewiring degron network	0.2222
p.T716S	DO231140	LAML	ICGC	VHTPVAT	DEG_SCF_FBW7_1	706:712	Mutation rewiring degron network	0.2222
p.V710I	DO233913	GACA	ICGC	VHTPVAT	DEG_SCF_FBW7_1	706:712	Mutation altering degron motif	0.5965
p.L733I	DO11776	GBM	ICGC	SSTFTSVPSM	DEG_COP1_1	743:752	Mutation rewiring degron network	0.0556
p.L733I	DO11776	GBM	ICGC	VSTPKSS	DEG_SCF_FBW7_1	735:741	Mutation rewiring degron network	0.2778
p.V735F	DO228976	LICA	ICGC	VSTPKSS	DEG_SCF_FBW7_1	735:741	Mutation altering degron motif	0.7068
p.V710F	DO229035	LICA	ICGC	VHTPVAT	DEG_SCF_FBW7_1	706:712	Mutation altering degron motif	0.5957
p.K714E	DO44832	LICA	ICGC	VHTPVAT	DEG_SCF_FBW7_1	706:712	Mutation blocking ubiquitination signal	0.7222
p.T745A	DO23544	LIRI	ICGC	SSTFTSVPSM	DEG_COP1_1	743:752	Mutation altering degron motif	0.7139
p.N726I	DO231106	LUSC	ICGC	VSTPKSS	DEG_SCF_FBW7_1	735:741	Mutation rewiring degron network	0.0833
p.S734Y	DO232761	PBCA	ICGC	SSTFTSVPSM	DEG_COP1_1	743:752	Mutation rewiring degron network	0.0833
p.S734Y	DO232761	PBCA	ICGC	VSTPKSS	DEG_SCF_FBW7_1	735:741	Mutation rewiring degron network	0.3056
p.T720S	SIDM00993	Plasma Cell Myeloma	GDSC	VHTPVAT	DEG_SCF_FBW7_1	706:712	Mutation rewiring degron network	0.1111
p.T720S	SIDM00373	Endometrial Carcinoma	GDSC	VHTPVAT	DEG_SCF_FBW7_1	706:712	Mutation rewiring degron network	0.1111
p.T720S	SIDM00322	Esophageal Squamous Cell Carcinoma	GDSC	VHTPVAT	DEG_SCF_FBW7_1	706:712	Mutation rewiring degron network	0.1111
p.T720S	SIDM00305	Ovarian Carcinoma	GDSC	VHTPVAT	DEG_SCF_FBW7_1	706:712	Mutation rewiring degron network	0.1111
p.T720S	SIDM00961	Ewing's Sarcoma	GDSC	VHTPVAT	DEG_SCF_FBW7_1	706:712	Mutation rewiring degron network	0.1111
p.T720S	SIDM00608	Plasma Cell Myeloma	GDSC	VHTPVAT	DEG_SCF_FBW7_1	706:712	Mutation rewiring degron network	0.1111
p.T720S	SIDM00570	Gastric Carcinoma	GDSC	VHTPVAT	DEG_SCF_FBW7_1	706:712	Mutation rewiring degron network	0.1111
p.T720S	SIDM00435	Acute Myeloid Leukemia	GDSC	VHTPVAT	DEG_SCF_FBW7_1	706:712	Mutation rewiring degron network	0.1111
p.T720S	SIDM00216	Colorectal Carcinoma	GDSC	VHTPVAT	DEG_SCF_FBW7_1	706:712	Mutation rewiring degron network	0.1111
p.T720S	SIDM00234	Other Solid Cancers	GDSC	VHTPVAT	DEG_SCF_FBW7_1	706:712	Mutation rewiring degron network	0.1111
p.T720S	SIDM01040	Ovarian Carcinoma	GDSC	VHTPVAT	DEG_SCF_FBW7_1	706:712	Mutation rewiring degron network	0.1111
p.T720S	SIDM00491	Thyroid Gland Carcinoma	GDSC	VHTPVAT	DEG_SCF_FBW7_1	706:712	Mutation rewiring degron network	0.1111
p.T720S	SIDM00553	Acute Myeloid Leukemia	GDSC	VHTPVAT	DEG_SCF_FBW7_1	706:712	Mutation rewiring degron network	0.1111
p.T720S	SIDM00370	T-Lymphoblastic Leukemia	GDSC	VHTPVAT	DEG_SCF_FBW7_1	706:712	Mutation rewiring degron network	0.1111
p.T720S	SIDM00308	Chronic Myelogenous Leukemia	GDSC	VHTPVAT	DEG_SCF_FBW7_1	706:712	Mutation rewiring degron network	0.1111
p.T720S	SIDM00548	Squamous Cell Lung Carcinoma	GDSC	VHTPVAT	DEG_SCF_FBW7_1	706:712	Mutation rewiring degron network	0.1111
p.T720S	SIDM01145	Gastric Carcinoma	GDSC	VHTPVAT	DEG_SCF_FBW7_1	706:712	Mutation rewiring degron network	0.1111
p.T720S	SIDM00571	Pancreatic Carcinoma	GDSC	VHTPVAT	DEG_SCF_FBW7_1	706:712	Mutation rewiring degron network	0.1111
p.T720S	SIDM00598	Squamous Cell Lung Carcinoma	GDSC	VHTPVAT	DEG_SCF_FBW7_1	706:712	Mutation rewiring degron network	0.1111
p.T720S	SIDM00394	Cervical Carcinoma	GDSC	VHTPVAT	DEG_SCF_FBW7_1	706:712	Mutation rewiring degron network	0.1111
p.T720S	SIDM00355	Non-Small Cell Lung Carcinoma	GDSC	VHTPVAT	DEG_SCF_FBW7_1	706:712	Mutation rewiring degron network	0.1111
p.T720S	SIDM00350	Head and Neck Carcinoma	GDSC	VHTPVAT	DEG_SCF_FBW7_1	706:712	Mutation rewiring degron network	0.1111
p.T720S	SIDM00235	Kidney Carcinoma	GDSC	VHTPVAT	DEG_SCF_FBW7_1	706:712	Mutation rewiring degron network	0.1111
p.T720S	SIDM00237	Non-Small Cell Lung Carcinoma	GDSC	VHTPVAT	DEG_SCF_FBW7_1	706:712	Mutation rewiring degron network	0.1111
p.T720S	SIDM00365	Small Cell Lung Carcinoma	GDSC	VHTPVAT	DEG_SCF_FBW7_1	706:712	Mutation rewiring degron network	0.1111
p.T720S	SIDM00410	Other Blood Cancers	GDSC	VHTPVAT	DEG_SCF_FBW7_1	706:712	Mutation rewiring degron network	0.1111
p.T720S	SIDM00567	Other Solid Cancers	GDSC	VHTPVAT	DEG_SCF_FBW7_1	706:712	Mutation rewiring degron network	0.1111
p.T720S	SIDM01019	Acute Myeloid Leukemia	GDSC	VHTPVAT	DEG_SCF_FBW7_1	706:712	Mutation rewiring degron network	0.1111
p.T720S	SIDM00989	Bladder Carcinoma	GDSC	VHTPVAT	DEG_SCF_FBW7_1	706:712	Mutation rewiring degron network	0.1111
p.T720S	SIDM00023	Esophageal Squamous Cell Carcinoma	GDSC	VHTPVAT	DEG_SCF_FBW7_1	706:712	Mutation rewiring degron network	0.1111
p.T720S	SIDM00655	Other Solid Cancers	GDSC	VHTPVAT	DEG_SCF_FBW7_1	706:712	Mutation rewiring degron network	0.1111
p.T720S	SIDM01217	Other Blood Cancers	GDSC	VHTPVAT	DEG_SCF_FBW7_1	706:712	Mutation rewiring degron network	0.1111
p.T720S	SIDM00368	Small Cell Lung Carcinoma	GDSC	VHTPVAT	DEG_SCF_FBW7_1	706:712	Mutation rewiring degron network	0.1111
p.T720S	SIDM00986	Head and Neck Carcinoma	GDSC	VHTPVAT	DEG_SCF_FBW7_1	706:712	Mutation rewiring degron network	0.1111
p.T720S	SIDM00045	Gastric Carcinoma	GDSC	VHTPVAT	DEG_SCF_FBW7_1	706:712	Mutation rewiring degron network	0.1111
p.T720S	SIDM00591	Oral Cavity Carcinoma	GDSC	VHTPVAT	DEG_SCF_FBW7_1	706:712	Mutation rewiring degron network	0.1111
p.T720S	SIDM00302	Other Solid Cancers	GDSC	VHTPVAT	DEG_SCF_FBW7_1	706:712	Mutation rewiring degron network	0.1111
p.T720S	SIDM01033	Bladder Carcinoma	GDSC	VHTPVAT	DEG_SCF_FBW7_1	706:712	Mutation rewiring degron network	0.1111
p.T720S	SIDM00531	Pancreatic Carcinoma	GDSC	VHTPVAT	DEG_SCF_FBW7_1	706:712	Mutation rewiring degron network	0.1111
p.T720S	SIDM00192	Colorectal Carcinoma	GDSC	VHTPVAT	DEG_SCF_FBW7_1	706:712	Mutation rewiring degron network	0.1111
p.T720S	SIDM01582	Gastric Carcinoma	GDSC	VHTPVAT	DEG_SCF_FBW7_1	706:712	Mutation rewiring degron network	0.1111
p.T720S	SIDM01449	Pancreatic Carcinoma	GDSC	VHTPVAT	DEG_SCF_FBW7_1	706:712	Mutation rewiring degron network	0.1111
p.T720S	SIDM01735	Biliary Tract Carcinoma	GDSC	VHTPVAT	DEG_SCF_FBW7_1	706:712	Mutation rewiring degron network	0.1111
p.T720S	SIDM01682	Gastric Carcinoma	GDSC	VHTPVAT	DEG_SCF_FBW7_1	706:712	Mutation rewiring degron network	0.1111
p.T720S	SIDM01617	Endometrial Carcinoma	GDSC	VHTPVAT	DEG_SCF_FBW7_1	706:712	Mutation rewiring degron network	0.1111
p.T720S	SIDM01335	Kidney Carcinoma	GDSC	VHTPVAT	DEG_SCF_FBW7_1	706:712	Mutation rewiring degron network	0.1111
p.T720S	SIDM01570	Ovarian Carcinoma	GDSC	VHTPVAT	DEG_SCF_FBW7_1	706:712	Mutation rewiring degron network	0.1111
p.T720S	SIDM00168	Head and Neck Carcinoma	GDSC	VHTPVAT	DEG_SCF_FBW7_1	706:712	Mutation rewiring degron network	0.1111
p.T720S	SIDM01511	Gastric Carcinoma	GDSC	VHTPVAT	DEG_SCF_FBW7_1	706:712	Mutation rewiring degron network	0.1111
p.T720S	SIDM00167	Head and Neck Carcinoma	GDSC	VHTPVAT	DEG_SCF_FBW7_1	706:712	Mutation rewiring degron network	0.1111
p.T720S	SIDM01444	Glioblastoma	GDSC	VHTPVAT	DEG_SCF_FBW7_1	706:712	Mutation rewiring degron network	0.1111
p.T720S	SIDM00008	Ovarian Carcinoma	GDSC	VHTPVAT	DEG_SCF_FBW7_1	706:712	Mutation rewiring degron network	0.1111
p.T720S	SIDM01336	Glioblastoma	GDSC	VHTPVAT	DEG_SCF_FBW7_1	706:712	Mutation rewiring degron network	0.1111
p.T720S	SIDM00170	Head and Neck Carcinoma	GDSC	VHTPVAT	DEG_SCF_FBW7_1	706:712	Mutation rewiring degron network	0.1111
p.T720S	SIDM01694	B-Lymphoblastic Leukemia	GDSC	VHTPVAT	DEG_SCF_FBW7_1	706:712	Mutation rewiring degron network	0.1111
p.T720S	SIDM01588	Endometrial Carcinoma	GDSC	VHTPVAT	DEG_SCF_FBW7_1	706:712	Mutation rewiring degron network	0.1111
p.T720S	SIDM01442	Glioma	GDSC	VHTPVAT	DEG_SCF_FBW7_1	706:712	Mutation rewiring degron network	0.1111
p.V753F	SIDM00183	Small Cell Lung Carcinoma	GDSC	SSTFTSVPSM	DEG_COP1_1	743:752	Mutation rewiring degron network	0.3056
p.V753F	LB647-SCLC	lung	COSMIC	SSTFTSVPSM	DEG_COP1_1	743:752	Mutation rewiring degron network	0.3056
p.P754S	SIDM00126	Melanoma	GDSC	SSTFTSVPSM	DEG_COP1_1	743:752	Mutation rewiring degron network	0.2778
p.P754S	K2	skin	COSMIC	SSTFTSVPSM	DEG_COP1_1	743:752	Mutation rewiring degron network	0.2778
p.A697T	SIDM00217	Colorectal Carcinoma	GDSC	VHTPVAT	DEG_SCF_FBW7_1	706:712	Mutation substituting flanking lysine	0.1944
p.A697T	SNU-1040	large intestine	COSMIC	VHTPVAT	DEG_SCF_FBW7_1	706:712	Mutation substituting flanking lysine	0.1944
p.P750S	ACH-002147	Skin Cancer	CCLE	SSTFTSVPSM	DEG_COP1_1	743:752	Mutation altering degron motif	0.6752
p.P750S	K2	skin	COSMIC	SSTFTSVPSM	DEG_COP1_1	743:752	Mutation altering degron motif	0.6752
p.V749F	ACH-002154	Lung Cancer	CCLE	SSTFTSVPSM	DEG_COP1_1	743:752	Mutation altering degron motif	0.7068
p.V749F	LB647-SCLC	lung	COSMIC	SSTFTSVPSM	DEG_COP1_1	743:752	Mutation altering degron motif	0.7068

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SCYL2

UniProt ID: Q6P3W7

Entrez ID: 55681

Protein name: SCY1-like protein 2 (Coated vesicle-associated kinase of 104 kDa)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SCYL2 in