DegronMD

Uniprot ID: Q6P3W7

Source protein: SCY1-like protein 2

Source gene: SCYL2

Class: DEG_SCF_FBW7_1

Location: 706:712

E3 ligase: FBXW7

DEGRON score: 0.9953

ASA_SCORE: 95.7714

COIL: 0.9446

CONS_SCORE: 0.2898

DSS_SCORE: 0.573

HELIX: 0.0221

FCONS_SCORE: 0.8627

RIG_SCORE: 0.7193

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T716S	DO228483	BRCA	ICGC	VHTPVAT	DEG_SCF_FBW7_1	0.2222
p.T716S	DO229013	COCA	ICGC	VHTPVAT	DEG_SCF_FBW7_1	0.2222
p.T716S	DO230659	LAML	ICGC	VHTPVAT	DEG_SCF_FBW7_1	0.2222
p.T716S	DO231140	LAML	ICGC	VHTPVAT	DEG_SCF_FBW7_1	0.2222
p.V710I	DO233913	GACA	ICGC	VHTPVAT	DEG_SCF_FBW7_1	0.5965
p.V710F	DO229035	LICA	ICGC	VHTPVAT	DEG_SCF_FBW7_1	0.5957
p.K714E	DO44832	LICA	ICGC	VHTPVAT	DEG_SCF_FBW7_1	0.7222
p.T720S	SIDM00993	Plasma Cell Myeloma	GDSC	VHTPVAT	DEG_SCF_FBW7_1	0.1111
p.T720S	SIDM00373	Endometrial Carcinoma	GDSC	VHTPVAT	DEG_SCF_FBW7_1	0.1111
p.T720S	SIDM00322	Esophageal Squamous Cell Carcinoma	GDSC	VHTPVAT	DEG_SCF_FBW7_1	0.1111
p.T720S	SIDM00305	Ovarian Carcinoma	GDSC	VHTPVAT	DEG_SCF_FBW7_1	0.1111
p.T720S	SIDM00961	Ewing's Sarcoma	GDSC	VHTPVAT	DEG_SCF_FBW7_1	0.1111
p.T720S	SIDM00608	Plasma Cell Myeloma	GDSC	VHTPVAT	DEG_SCF_FBW7_1	0.1111
p.T720S	SIDM00570	Gastric Carcinoma	GDSC	VHTPVAT	DEG_SCF_FBW7_1	0.1111
p.T720S	SIDM00435	Acute Myeloid Leukemia	GDSC	VHTPVAT	DEG_SCF_FBW7_1	0.1111
p.T720S	SIDM00216	Colorectal Carcinoma	GDSC	VHTPVAT	DEG_SCF_FBW7_1	0.1111
p.T720S	SIDM00234	Other Solid Cancers	GDSC	VHTPVAT	DEG_SCF_FBW7_1	0.1111
p.T720S	SIDM01040	Ovarian Carcinoma	GDSC	VHTPVAT	DEG_SCF_FBW7_1	0.1111
p.T720S	SIDM00491	Thyroid Gland Carcinoma	GDSC	VHTPVAT	DEG_SCF_FBW7_1	0.1111
p.T720S	SIDM00553	Acute Myeloid Leukemia	GDSC	VHTPVAT	DEG_SCF_FBW7_1	0.1111
p.T720S	SIDM00370	T-Lymphoblastic Leukemia	GDSC	VHTPVAT	DEG_SCF_FBW7_1	0.1111
p.T720S	SIDM00308	Chronic Myelogenous Leukemia	GDSC	VHTPVAT	DEG_SCF_FBW7_1	0.1111
p.T720S	SIDM00548	Squamous Cell Lung Carcinoma	GDSC	VHTPVAT	DEG_SCF_FBW7_1	0.1111
p.T720S	SIDM01145	Gastric Carcinoma	GDSC	VHTPVAT	DEG_SCF_FBW7_1	0.1111
p.T720S	SIDM00571	Pancreatic Carcinoma	GDSC	VHTPVAT	DEG_SCF_FBW7_1	0.1111
p.T720S	SIDM00598	Squamous Cell Lung Carcinoma	GDSC	VHTPVAT	DEG_SCF_FBW7_1	0.1111
p.T720S	SIDM00394	Cervical Carcinoma	GDSC	VHTPVAT	DEG_SCF_FBW7_1	0.1111
p.T720S	SIDM00355	Non-Small Cell Lung Carcinoma	GDSC	VHTPVAT	DEG_SCF_FBW7_1	0.1111
p.T720S	SIDM00350	Head and Neck Carcinoma	GDSC	VHTPVAT	DEG_SCF_FBW7_1	0.1111
p.T720S	SIDM00235	Kidney Carcinoma	GDSC	VHTPVAT	DEG_SCF_FBW7_1	0.1111
p.T720S	SIDM00237	Non-Small Cell Lung Carcinoma	GDSC	VHTPVAT	DEG_SCF_FBW7_1	0.1111
p.T720S	SIDM00365	Small Cell Lung Carcinoma	GDSC	VHTPVAT	DEG_SCF_FBW7_1	0.1111
p.T720S	SIDM00410	Other Blood Cancers	GDSC	VHTPVAT	DEG_SCF_FBW7_1	0.1111
p.T720S	SIDM00567	Other Solid Cancers	GDSC	VHTPVAT	DEG_SCF_FBW7_1	0.1111
p.T720S	SIDM01019	Acute Myeloid Leukemia	GDSC	VHTPVAT	DEG_SCF_FBW7_1	0.1111
p.T720S	SIDM00989	Bladder Carcinoma	GDSC	VHTPVAT	DEG_SCF_FBW7_1	0.1111
p.T720S	SIDM00023	Esophageal Squamous Cell Carcinoma	GDSC	VHTPVAT	DEG_SCF_FBW7_1	0.1111
p.T720S	SIDM00655	Other Solid Cancers	GDSC	VHTPVAT	DEG_SCF_FBW7_1	0.1111
p.T720S	SIDM01217	Other Blood Cancers	GDSC	VHTPVAT	DEG_SCF_FBW7_1	0.1111
p.T720S	SIDM00368	Small Cell Lung Carcinoma	GDSC	VHTPVAT	DEG_SCF_FBW7_1	0.1111
p.T720S	SIDM00986	Head and Neck Carcinoma	GDSC	VHTPVAT	DEG_SCF_FBW7_1	0.1111
p.T720S	SIDM00045	Gastric Carcinoma	GDSC	VHTPVAT	DEG_SCF_FBW7_1	0.1111
p.T720S	SIDM00591	Oral Cavity Carcinoma	GDSC	VHTPVAT	DEG_SCF_FBW7_1	0.1111
p.T720S	SIDM00302	Other Solid Cancers	GDSC	VHTPVAT	DEG_SCF_FBW7_1	0.1111
p.T720S	SIDM01033	Bladder Carcinoma	GDSC	VHTPVAT	DEG_SCF_FBW7_1	0.1111
p.T720S	SIDM00531	Pancreatic Carcinoma	GDSC	VHTPVAT	DEG_SCF_FBW7_1	0.1111
p.T720S	SIDM00192	Colorectal Carcinoma	GDSC	VHTPVAT	DEG_SCF_FBW7_1	0.1111
p.T720S	SIDM01582	Gastric Carcinoma	GDSC	VHTPVAT	DEG_SCF_FBW7_1	0.1111
p.T720S	SIDM01449	Pancreatic Carcinoma	GDSC	VHTPVAT	DEG_SCF_FBW7_1	0.1111
p.T720S	SIDM01735	Biliary Tract Carcinoma	GDSC	VHTPVAT	DEG_SCF_FBW7_1	0.1111
p.T720S	SIDM01682	Gastric Carcinoma	GDSC	VHTPVAT	DEG_SCF_FBW7_1	0.1111
p.T720S	SIDM01617	Endometrial Carcinoma	GDSC	VHTPVAT	DEG_SCF_FBW7_1	0.1111
p.T720S	SIDM01335	Kidney Carcinoma	GDSC	VHTPVAT	DEG_SCF_FBW7_1	0.1111
p.T720S	SIDM01570	Ovarian Carcinoma	GDSC	VHTPVAT	DEG_SCF_FBW7_1	0.1111
p.T720S	SIDM00168	Head and Neck Carcinoma	GDSC	VHTPVAT	DEG_SCF_FBW7_1	0.1111
p.T720S	SIDM01511	Gastric Carcinoma	GDSC	VHTPVAT	DEG_SCF_FBW7_1	0.1111
p.T720S	SIDM00167	Head and Neck Carcinoma	GDSC	VHTPVAT	DEG_SCF_FBW7_1	0.1111
p.T720S	SIDM01444	Glioblastoma	GDSC	VHTPVAT	DEG_SCF_FBW7_1	0.1111
p.T720S	SIDM00008	Ovarian Carcinoma	GDSC	VHTPVAT	DEG_SCF_FBW7_1	0.1111
p.T720S	SIDM01336	Glioblastoma	GDSC	VHTPVAT	DEG_SCF_FBW7_1	0.1111
p.T720S	SIDM00170	Head and Neck Carcinoma	GDSC	VHTPVAT	DEG_SCF_FBW7_1	0.1111
p.T720S	SIDM01694	B-Lymphoblastic Leukemia	GDSC	VHTPVAT	DEG_SCF_FBW7_1	0.1111
p.T720S	SIDM01588	Endometrial Carcinoma	GDSC	VHTPVAT	DEG_SCF_FBW7_1	0.1111
p.T720S	SIDM01442	Glioma	GDSC	VHTPVAT	DEG_SCF_FBW7_1	0.1111
p.A697T	SIDM00217	Colorectal Carcinoma	GDSC	VHTPVAT	DEG_SCF_FBW7_1	0.1944
p.A697T	SNU-1040	large_intestine	COSMIC	VHTPVAT	DEG_SCF_FBW7_1	0.1944

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VHTPVAT

Degron related mutations and impact score

Drug responses associated with SCYL2 mutations

All proteins holding degron of VHTPVAT

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6P3W7	SCY1-like protein 2	DEG_SCF_FBW7_1	706:712	VHTPVAT	FBXW7	0.9953	More...