DegronMD

Uniprot ID: Q6P3W7

Source protein: SCY1-like protein 2

Source gene: SCYL2

Class: DEG_SCF_FBW7_1

Location: 735:741

E3 ligase: FBXW7

DEGRON score: 0.9988

ASA_SCORE: 97.5429

COIL: 0.9646

CONS_SCORE: 0.364

DSS_SCORE: 0.415

HELIX: 0.021

FCONS_SCORE: 1.2778

RIG_SCORE: 0.634

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P738T	TCGA-BF-A1Q0	SKCM	TCGA	VSTPKSS	DEG_SCF_FBW7_1	0.7031
p.P738T	DO47374	SKCM	ICGC	VSTPKSS	DEG_SCF_FBW7_1	0.7031
p.L733I	DO11776	GBM	ICGC	VSTPKSS	DEG_SCF_FBW7_1	0.2778
p.V735F	DO228976	LICA	ICGC	VSTPKSS	DEG_SCF_FBW7_1	0.7068
p.N726I	DO231106	LUSC	ICGC	VSTPKSS	DEG_SCF_FBW7_1	0.0833
p.S734Y	DO232761	PBCA	ICGC	VSTPKSS	DEG_SCF_FBW7_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6P3W7	SCY1-like protein 2	DEG_SCF_FBW7_1	735:741	VSTPKSS	FBXW7	0.9988	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons