DegronMD

Uniprot ID: Q9NXB0

Source protein: Meckel syndrome type 1 protein

Source gene: MKS1

Class: DEG_Kelch_Keap1_1

Location: 7:12

E3 ligase: KEAP1

DEGRON score: 0.9902

ASA_SCORE: 68.5

COIL: 0.7717

CONS_SCORE: 0.2627

DSS_SCORE: 0.4286

HELIX: 0.027

FCONS_SCORE: 0.4775

RIG_SCORE: 0.7674

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E3K	TCGA-LL-A6FP	BRCA	TCGA	STDTGE	DEG_Kelch_Keap1_1	0.2222
p.E3K	DO51212	BRCA	ICGC	STDTGE	DEG_Kelch_Keap1_1	0.2222
p.T4N	DO229018	LICA	ICGC	STDTGE	DEG_Kelch_Keap1_1	0.25
p.D19E	DO229036	LICA	ICGC	STDTGE	DEG_Kelch_Keap1_1	0.1389
p.R16S	DO229035	LICA	ICGC	STDTGE	DEG_Kelch_Keap1_1	0.2222
p.W6C	ACH-000599	Pancreatic Cancer	CCLE	STDTGE	DEG_Kelch_Keap1_1	0.3056
p.V21M	ACH-000994	Endometrial/Uterine Cancer	CCLE	STDTGE	DEG_Kelch_Keap1_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NXB0	Meckel syndrome type 1 protein	DEG_Kelch_Keap1_1	7:12	STDTGE	KEAP1	0.9902	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons