DegronMD

Uniprot ID: Q8NI77

Source protein: Kinesin-like protein KIF18A

Source gene: KIF18A

Class: DEG_COP1_1

Location: 806:816

E3 ligase: COP1

DEGRON score: 0.8253

ASA_SCORE: 94.0545

COIL: 0.9103

CONS_SCORE: 0.3616

DSS_SCORE: 0.533

HELIX: 0.0568

FCONS_SCORE: 0.8006

RIG_SCORE: 0.6374

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R799W	TCGA-12-0775	GBM	TCGA	STKHSMPVPSM	DEG_COP1_1	0.1389
p.R799W	TCGA-A5-A0G2	UCEC	TCGA	STKHSMPVPSM	DEG_COP1_1	0.1389
p.R799W	TCGA-UF-A71D	HNSC	TCGA	STKHSMPVPSM	DEG_COP1_1	0.1389
p.R799W	DO14133	GBM	ICGC	STKHSMPVPSM	DEG_COP1_1	0.1389
p.R799W	DO52109	HNSC	ICGC	STKHSMPVPSM	DEG_COP1_1	0.1389
p.R799W	DO41235	UCEC	ICGC	STKHSMPVPSM	DEG_COP1_1	0.1389
p.R799W	SIDM01154	T-Lymphoblastic Leukemia	GDSC	STKHSMPVPSM	DEG_COP1_1	0.1389
p.R799W	SUP-T1	haematopoietic_and_lymphoid_tissue	COSMIC	STKHSMPVPSM	DEG_COP1_1	0.1389
p.S819C	TCGA-18-5592	LUSC	TCGA	STKHSMPVPSM	DEG_COP1_1	0.25
p.S819C	DO26432	LUSC	ICGC	STKHSMPVPSM	DEG_COP1_1	0.25
p.P818S	TCGA-5M-AAT6	COAD	TCGA	STKHSMPVPSM	DEG_COP1_1	0.2778
p.P818S	DO223703	COAD	ICGC	STKHSMPVPSM	DEG_COP1_1	0.2778
p.M816I	TCGA-EE-A29Q	SKCM	TCGA	STKHSMPVPSM	DEG_COP1_1	0.6507
p.M816I	DO37866	SKCM	ICGC	STKHSMPVPSM	DEG_COP1_1	0.6507
p.A822V	DO228138	PBCA	ICGC	STKHSMPVPSM	DEG_COP1_1	0.1667
p.R799Q	DO229221	THCA	ICGC	STKHSMPVPSM	DEG_COP1_1	0.1389
p.D801Y	ACH-000202	Colon/Colorectal Cancer	CCLE	STKHSMPVPSM	DEG_COP1_1	0.1944
p.D801Y	ACH-000491	Colon/Colorectal Cancer	CCLE	STKHSMPVPSM	DEG_COP1_1	0.1944
p.D801Y	ACH-000501	Colon/Colorectal Cancer	CCLE	STKHSMPVPSM	DEG_COP1_1	0.1944
p.D801Y	ACH-000552	Colon/Colorectal Cancer	CCLE	STKHSMPVPSM	DEG_COP1_1	0.1944
p.D801Y	ACH-000860	Lung Cancer	CCLE	STKHSMPVPSM	DEG_COP1_1	0.1944
p.D801Y	ACH-000950	Colon/Colorectal Cancer	CCLE	STKHSMPVPSM	DEG_COP1_1	0.1944
p.D801Y	ACH-000987	Skin Cancer	CCLE	STKHSMPVPSM	DEG_COP1_1	0.1944
p.D801Y	ACH-001039	Colon/Colorectal Cancer	CCLE	STKHSMPVPSM	DEG_COP1_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8NI77	Kinesin-like protein KIF18A	DEG_COP1_1	806:816	STKHSMPVPSM	COP1	0.8253	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons