DegronMD - Q8NI77(KIF18A)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R799W	TCGA-12-0775	GBM	TCGA	STKHSMPVPSM	DEG_COP1_1	806:816	Mutation rewiring degron network	0.1389
p.R799W	TCGA-A5-A0G2	UCEC	TCGA	STKHSMPVPSM	DEG_COP1_1	806:816	Mutation rewiring degron network	0.1389
p.R799W	TCGA-UF-A71D	HNSC	TCGA	STKHSMPVPSM	DEG_COP1_1	806:816	Mutation rewiring degron network	0.1389
p.R799W	DO14133	GBM	ICGC	STKHSMPVPSM	DEG_COP1_1	806:816	Mutation rewiring degron network	0.1389
p.R799W	DO52109	HNSC	ICGC	STKHSMPVPSM	DEG_COP1_1	806:816	Mutation rewiring degron network	0.1389
p.R799W	DO41235	UCEC	ICGC	STKHSMPVPSM	DEG_COP1_1	806:816	Mutation rewiring degron network	0.1389
p.R799W	SIDM01154	T-Lymphoblastic Leukemia	GDSC	STKHSMPVPSM	DEG_COP1_1	806:816	Mutation rewiring degron network	0.1389
p.R799W	SUP-T1	haematopoietic and lymphoid tissue	COSMIC	STKHSMPVPSM	DEG_COP1_1	806:816	Mutation rewiring degron network	0.1389
p.S819C	TCGA-18-5592	LUSC	TCGA	STKHSMPVPSM	DEG_COP1_1	806:816	Mutation rewiring degron network	0.25
p.S819C	DO26432	LUSC	ICGC	STKHSMPVPSM	DEG_COP1_1	806:816	Mutation rewiring degron network	0.25
p.P818S	TCGA-5M-AAT6	COAD	TCGA	STKHSMPVPSM	DEG_COP1_1	806:816	Mutation rewiring degron network	0.2778
p.P818S	DO223703	COAD	ICGC	STKHSMPVPSM	DEG_COP1_1	806:816	Mutation rewiring degron network	0.2778
p.I892V	TCGA-AR-A0TV	BRCA	TCGA	NLR	DEG_APCC_TPR_1	896:898	Mutation rewiring degron network	0.2222
p.I892V	DO4879	BRCA	ICGC	NLR	DEG_APCC_TPR_1	896:898	Mutation rewiring degron network	0.2222
p.N891H	TCGA-D3-A8GM	SKCM	TCGA	NLR	DEG_APCC_TPR_1	896:898	Mutation rewiring degron network	0.1944
p.N891H	DO50288	SKCM	ICGC	NLR	DEG_APCC_TPR_1	896:898	Mutation rewiring degron network	0.1944
p.M816I	TCGA-EE-A29Q	SKCM	TCGA	STKHSMPVPSM	DEG_COP1_1	806:816	Mutation altering degron motif	0.6507
p.M816I	DO37866	SKCM	ICGC	STKHSMPVPSM	DEG_COP1_1	806:816	Mutation altering degron motif	0.6507
p.L897I	TCGA-EO-A3B0	UCEC	TCGA	NLR	DEG_APCC_TPR_1	896:898	Mutation altering degron motif	0.6063
p.L897I	DO219773	UCEC	ICGC	NLR	DEG_APCC_TPR_1	896:898	Mutation altering degron motif	0.6063
p.A822V	DO228138	PBCA	ICGC	STKHSMPVPSM	DEG_COP1_1	806:816	Mutation rewiring degron network	0.1667
p.R799Q	DO229221	THCA	ICGC	STKHSMPVPSM	DEG_COP1_1	806:816	Mutation rewiring degron network	0.1389
p.R886T	SIDM00627	Cervical Carcinoma	GDSC	NLR	DEG_APCC_TPR_1	896:898	Mutation rewiring degron network	0.0556
p.R886T	ACH-000490	Cervical Cancer	CCLE	NLR	DEG_APCC_TPR_1	896:898	Mutation rewiring degron network	0.0556
p.R886T	ACH-001359	Cervical Cancer	CCLE	NLR	DEG_APCC_TPR_1	896:898	Mutation rewiring degron network	0.0556
p.R886T	ME-180	cervix	COSMIC	NLR	DEG_APCC_TPR_1	896:898	Mutation rewiring degron network	0.0556
p.D801Y	ACH-000202	Colon/Colorectal Cancer	CCLE	STKHSMPVPSM	DEG_COP1_1	806:816	Mutation rewiring degron network	0.1944
p.D801Y	ACH-000491	Colon/Colorectal Cancer	CCLE	STKHSMPVPSM	DEG_COP1_1	806:816	Mutation rewiring degron network	0.1944
p.D801Y	ACH-000501	Colon/Colorectal Cancer	CCLE	STKHSMPVPSM	DEG_COP1_1	806:816	Mutation rewiring degron network	0.1944
p.D801Y	ACH-000552	Colon/Colorectal Cancer	CCLE	STKHSMPVPSM	DEG_COP1_1	806:816	Mutation rewiring degron network	0.1944
p.D801Y	ACH-000860	Lung Cancer	CCLE	STKHSMPVPSM	DEG_COP1_1	806:816	Mutation rewiring degron network	0.1944
p.D801Y	ACH-000950	Colon/Colorectal Cancer	CCLE	STKHSMPVPSM	DEG_COP1_1	806:816	Mutation rewiring degron network	0.1944
p.D801Y	ACH-000987	Skin Cancer	CCLE	STKHSMPVPSM	DEG_COP1_1	806:816	Mutation rewiring degron network	0.1944
p.D801Y	ACH-001039	Colon/Colorectal Cancer	CCLE	STKHSMPVPSM	DEG_COP1_1	806:816	Mutation rewiring degron network	0.1944

Kaplan plot for KIF18A in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

KIF18A

UniProt ID: Q8NI77

Entrez ID: 81930

Protein name: Kinesin-like protein KIF18A (Marrow stromal KIF18A) (MS-KIF18A)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for KIF18A in