DegronMD

Uniprot ID: Q8NI77

Source protein: Kinesin-like protein KIF18A

Source gene: KIF18A

Class: DEG_APCC_TPR_1

Location: 896:898

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9668

ASA_SCORE: 144.9667

COIL: 0.915

CONS_SCORE: 0.3746

DSS_SCORE: 0.9114

HELIX: 0.068

FCONS_SCORE: 1.0731

RIG_SCORE: 0.7056

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.I892V	TCGA-AR-A0TV	BRCA	TCGA	NLR	DEG_APCC_TPR_1	0.2222
p.I892V	DO4879	BRCA	ICGC	NLR	DEG_APCC_TPR_1	0.2222
p.N891H	TCGA-D3-A8GM	SKCM	TCGA	NLR	DEG_APCC_TPR_1	0.1944
p.N891H	DO50288	SKCM	ICGC	NLR	DEG_APCC_TPR_1	0.1944
p.L897I	TCGA-EO-A3B0	UCEC	TCGA	NLR	DEG_APCC_TPR_1	0.6063
p.L897I	DO219773	UCEC	ICGC	NLR	DEG_APCC_TPR_1	0.6063
p.R886T	SIDM00627	Cervical Carcinoma	GDSC	NLR	DEG_APCC_TPR_1	0.0556
p.R886T	ACH-000490	Cervical Cancer	CCLE	NLR	DEG_APCC_TPR_1	0.0556
p.R886T	ACH-001359	Cervical Cancer	CCLE	NLR	DEG_APCC_TPR_1	0.0556
p.R886T	ME-180	cervix	COSMIC	NLR	DEG_APCC_TPR_1	0.0556

DegronMD: protein-targeted degradation, mutation and drug response to degrons