DegronMD

Uniprot ID: Q8WXI7

Source protein: Mucin-16

Source gene: MUC16

Class: DEG_COP1_1

Location: 6487:6496

E3 ligase: COP1

DEGRON score: 0.6651

ASA_SCORE: 101.36

COIL: 0.8697

CONS_SCORE: 0

DSS_SCORE: 0.4277

HELIX: 0.0204

FCONS_SCORE: 0

RIG_SCORE: 0.7438

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L6486S	TCGA-06-0152	GBM	TCGA	STLTSRVPEY	DEG_COP1_1	0.3056
p.L6486S	DO11238	GBM	ICGC	STLTSRVPEY	DEG_COP1_1	0.3056
p.T6488N	TCGA-06-5416	GBM	TCGA	STLTSRVPEY	DEG_COP1_1	0.5944
p.T6488N	DO10880	GBM	ICGC	STLTSRVPEY	DEG_COP1_1	0.5944
p.T6500R	TCGA-15-0742	GBM	TCGA	STLTSRVPEY	DEG_COP1_1	0.2222
p.T6500R	DO13623	GBM	ICGC	STLTSRVPEY	DEG_COP1_1	0.2222
p.V6505E	TCGA-49-4488	LUAD	TCGA	STLTSRVPEY	DEG_COP1_1	0.0833
p.V6505E	DO24750	LUAD	ICGC	STLTSRVPEY	DEG_COP1_1	0.0833
p.G6499E	TCGA-AJ-A3OK	UCEC	TCGA	STLTSRVPEY	DEG_COP1_1	0.25
p.G6499E	DO43602	UCEC	ICGC	STLTSRVPEY	DEG_COP1_1	0.25
p.G6480R	TCGA-D3-A1Q4	SKCM	TCGA	STLTSRVPEY	DEG_COP1_1	0.1389
p.G6480R	DO220881	MELA	ICGC	STLTSRVPEY	DEG_COP1_1	0.1389
p.G6480R	DO222702	MELA	ICGC	STLTSRVPEY	DEG_COP1_1	0.1389
p.G6480R	DO47631	SKCM	ICGC	STLTSRVPEY	DEG_COP1_1	0.1389
p.E6506K	TCGA-D3-A2JO	SKCM	TCGA	STLTSRVPEY	DEG_COP1_1	0.0556
p.E6506K	DO220903	MELA	ICGC	STLTSRVPEY	DEG_COP1_1	0.0556
p.E6506K	DO220902	MELA	ICGC	STLTSRVPEY	DEG_COP1_1	0.0556
p.E6506K	DO47619	SKCM	ICGC	STLTSRVPEY	DEG_COP1_1	0.0556
p.G6480E	TCGA-D3-A5GN	SKCM	TCGA	STLTSRVPEY	DEG_COP1_1	0.1389
p.G6480E	DO47317	SKCM	ICGC	STLTSRVPEY	DEG_COP1_1	0.1389
p.S6482L	TCGA-EB-A5UN	SKCM	TCGA	STLTSRVPEY	DEG_COP1_1	0.1944
p.S6482L	DO47267	SKCM	ICGC	STLTSRVPEY	DEG_COP1_1	0.1944
p.T6490M	DO234380	ESAD	ICGC	STLTSRVPEY	DEG_COP1_1	0.7423
p.T6478N	DO229029	LICA	ICGC	STLTSRVPEY	DEG_COP1_1	0.0833
p.P6503H	DO229045	LICA	ICGC	STLTSRVPEY	DEG_COP1_1	0.1389
p.M6477I	DO231136	LUSC	ICGC	STLTSRVPEY	DEG_COP1_1	0.0556
p.Y6496C	SIDM01090	Colorectal Carcinoma	GDSC	STLTSRVPEY	DEG_COP1_1	0.7087
p.Y6496C	ACH-000943	Colon/Colorectal Cancer	CCLE	STLTSRVPEY	DEG_COP1_1	0.7087
p.Y6496C	RKO	large_intestine	COSMIC	STLTSRVPEY	DEG_COP1_1	0.7087
p.S6504Y	SIDM00477	Esophageal Carcinoma	GDSC	STLTSRVPEY	DEG_COP1_1	0.1111
p.S6504Y	SIDM00803	Kidney Carcinoma	GDSC	STLTSRVPEY	DEG_COP1_1	0.1111
p.S6504Y	SIDM00999	Bladder Carcinoma	GDSC	STLTSRVPEY	DEG_COP1_1	0.1111
p.S6504Y	SIDM00677	Colorectal Carcinoma	GDSC	STLTSRVPEY	DEG_COP1_1	0.1111
p.S6501N	ACH-001411	Bladder Cancer	CCLE	STLTSRVPEY	DEG_COP1_1	0.1944

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: STLTSRVPEY

Degron related mutations and impact score

Drug responses associated with MUC16 mutations

All proteins holding degron of STLTSRVPEY

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8WXI7	Mucin-16	DEG_COP1_1	6487:6496	STLTSRVPEY	COP1	0.6651	More...