DegronMD

Uniprot ID: O14645

Source protein: Axonemal dynein light intermediate polypeptide 1

Source gene: DNALI1

Class: DEG_COP1_1

Location: 54:61

E3 ligase: COP1

DEGRON score: 0.9444

ASA_SCORE: 84.9875

COIL: 0.9554

CONS_SCORE: 0.2743

DSS_SCORE: 0.705

HELIX: 0.0219

FCONS_SCORE: 0.5907

RIG_SCORE: 0.6459

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G64C	TCGA-AX-A1CE	UCEC	TCGA	STPCVPDP	DEG_COP1_1	0.25
p.G64C	DO42280	UCEC	ICGC	STPCVPDP	DEG_COP1_1	0.25
p.E44D	TCGA-AZ-4315	COAD	TCGA	STPCVPDP	DEG_COP1_1	0.0556
p.E44D	DO8842	COAD	ICGC	STPCVPDP	DEG_COP1_1	0.0556
p.V55A	TCGA-BR-6452	STAD	TCGA	STPCVPDP	DEG_COP1_1	0.6936
p.V55A	DO38404	STAD	ICGC	STPCVPDP	DEG_COP1_1	0.6936
p.K54Q	TCGA-EO-A22X	UCEC	TCGA	STPCVPDP	DEG_COP1_1	0.6944
p.K54Q	DO43907	UCEC	ICGC	STPCVPDP	DEG_COP1_1	0.6944
p.P67T	DO222492	COCA	ICGC	STPCVPDP	DEG_COP1_1	0.1667
p.S65L	DO220877	MELA	ICGC	STPCVPDP	DEG_COP1_1	0.2222
p.R51Q	SIDM00782	Colorectal Carcinoma	GDSC	STPCVPDP	DEG_COP1_1	0.3611
p.R51Q	ACH-000381	Colon/Colorectal Cancer	CCLE	STPCVPDP	DEG_COP1_1	0.3611
p.R51Q	T84	large_intestine	COSMIC	STPCVPDP	DEG_COP1_1	0.3611
p.G64D	SIDM00140	Melanoma	GDSC	STPCVPDP	DEG_COP1_1	0.25
p.G64D	ACH-000968	Skin Cancer	CCLE	STPCVPDP	DEG_COP1_1	0.25
p.G64D	COLO-792	skin	COSMIC	STPCVPDP	DEG_COP1_1	0.25
p.K71M	ACH-000490	Cervical Cancer	CCLE	STPCVPDP	DEG_COP1_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O14645	Axonemal dynein light intermediate polypeptide 1	DEG_COP1_1	54:61	STPCVPDP	COP1	0.9444	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons