DegronMD

Uniprot ID: O60563

Source protein: Cyclin-T1

Source gene: CCNT1

Class: DEG_COP1_1

Location: 303:313

E3 ligase: COP1

DEGRON score: 0.9987

ASA_SCORE: 86.0182

COIL: 0.9517

CONS_SCORE: 0.404

DSS_SCORE: 0.516

HELIX: 0.0345

FCONS_SCORE: 1.0549

RIG_SCORE: 0.6682

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S308C	TCGA-55-7907	LUAD	TCGA	STSTTSAVPSL	DEG_COP1_1	0.643
p.S308C	DO25396	LUAD	ICGC	STSTTSAVPSL	DEG_COP1_1	0.643
p.N322S	TCGA-A6-5664	COAD	TCGA	STSTTSAVPSL	DEG_COP1_1	0.0833
p.N322S	DO8834	COAD	ICGC	STSTTSAVPSL	DEG_COP1_1	0.0833
p.E317K	TCGA-AX-A2HD	UCEC	TCGA	STSTTSAVPSL	DEG_COP1_1	0.2222
p.E317K	TCGA-ND-A4WC	UCS	TCGA	STSTTSAVPSL	DEG_COP1_1	0.2222
p.E317K	DO42608	UCEC	ICGC	STSTTSAVPSL	DEG_COP1_1	0.2222
p.S312C	TCGA-C5-A1MH	CESC	TCGA	STSTTSAVPSL	DEG_COP1_1	0.7541
p.S312C	DO48982	CESC	ICGC	STSTTSAVPSL	DEG_COP1_1	0.7541
p.V310A	TCGA-C8-A26Y	BRCA	TCGA	STSTTSAVPSL	DEG_COP1_1	0.6936
p.V310A	DO1273	BRCA	ICGC	STSTTSAVPSL	DEG_COP1_1	0.6936
p.S303L	TCGA-CV-6961	HNSC	TCGA	STSTTSAVPSL	DEG_COP1_1	0.7667
p.S303L	DO14566	HNSC	ICGC	STSTTSAVPSL	DEG_COP1_1	0.7667
p.T307K	TCGA-QK-A6VC	HNSC	TCGA	STSTTSAVPSL	DEG_COP1_1	0.7306
p.T307K	DO219056	HNSC	ICGC	STSTTSAVPSL	DEG_COP1_1	0.7306
p.S308N	DO222765	COCA	ICGC	STSTTSAVPSL	DEG_COP1_1	0.5958
p.A297E	DO228976	LICA	ICGC	STSTTSAVPSL	DEG_COP1_1	0.1667
p.T306N	DO229028	LICA	ICGC	STSTTSAVPSL	DEG_COP1_1	0.5944
p.A309E	DO229009	LICA	ICGC	STSTTSAVPSL	DEG_COP1_1	0.659
p.V315I	SIDM00660	Colorectal Carcinoma	GDSC	STSTTSAVPSL	DEG_COP1_1	0.2778
p.V315I	ACH-000985	Colon/Colorectal Cancer	CCLE	STSTTSAVPSL	DEG_COP1_1	0.2778
p.V315I	LS-411N	large_intestine	COSMIC	STSTTSAVPSL	DEG_COP1_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O60563	Cyclin-T1	DEG_COP1_1	303:313	STSTTSAVPSL	COP1	0.9987	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons