DegronMD - O60563(CCNT1)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Data table is loading....

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S308C	TCGA-55-7907	LUAD	TCGA	STSTTSAVPSL	DEG_COP1_1	303:313	Mutation altering degron motif	0.643
p.S308C	DO25396	LUAD	ICGC	STSTTSAVPSL	DEG_COP1_1	303:313	Mutation altering degron motif	0.643
p.P686S	TCGA-97-A4M5	LUAD	TCGA	VRPYSD	LIG_APCC_ABBA_1	684:689	Mutation altering degron motif	0.6752
p.P686S	DO218938	LUAD	ICGC	VRPYSD	LIG_APCC_ABBA_1	684:689	Mutation altering degron motif	0.6752
p.N322S	TCGA-A6-5664	COAD	TCGA	STSTTSAVPSL	DEG_COP1_1	303:313	Mutation rewiring degron network	0.0833
p.N322S	DO8834	COAD	ICGC	STSTTSAVPSL	DEG_COP1_1	303:313	Mutation rewiring degron network	0.0833
p.T676I	TCGA-A8-A09Z	BRCA	TCGA	VRPYSD	LIG_APCC_ABBA_1	684:689	Mutation rewiring degron network	0.1111
p.T676I	DO5521	BRCA	ICGC	VRPYSD	LIG_APCC_ABBA_1	684:689	Mutation rewiring degron network	0.1111
p.E317K	TCGA-AX-A2HD	UCEC	TCGA	STSTTSAVPSL	DEG_COP1_1	303:313	Mutation rewiring degron network	0.2222
p.E317K	TCGA-ND-A4WC	UCS	TCGA	STSTTSAVPSL	DEG_COP1_1	303:313	Mutation rewiring degron network	0.2222
p.E317K	DO42608	UCEC	ICGC	STSTTSAVPSL	DEG_COP1_1	303:313	Mutation rewiring degron network	0.2222
p.S312C	TCGA-C5-A1MH	CESC	TCGA	STSTTSAVPSL	DEG_COP1_1	303:313	Mutation altering degron motif	0.7541
p.S312C	DO48982	CESC	ICGC	STSTTSAVPSL	DEG_COP1_1	303:313	Mutation altering degron motif	0.7541
p.V310A	TCGA-C8-A26Y	BRCA	TCGA	STSTTSAVPSL	DEG_COP1_1	303:313	Mutation altering degron motif	0.6936
p.V310A	DO1273	BRCA	ICGC	STSTTSAVPSL	DEG_COP1_1	303:313	Mutation altering degron motif	0.6936
p.S303L	TCGA-CV-6961	HNSC	TCGA	STSTTSAVPSL	DEG_COP1_1	303:313	Mutation altering degron motif	0.7667
p.S303L	DO14566	HNSC	ICGC	STSTTSAVPSL	DEG_COP1_1	303:313	Mutation altering degron motif	0.7667
p.T307K	TCGA-QK-A6VC	HNSC	TCGA	STSTTSAVPSL	DEG_COP1_1	303:313	Mutation altering degron motif	0.7306
p.T307K	DO219056	HNSC	ICGC	STSTTSAVPSL	DEG_COP1_1	303:313	Mutation altering degron motif	0.7306
p.S308N	DO222765	COCA	ICGC	STSTTSAVPSL	DEG_COP1_1	303:313	Mutation altering degron motif	0.5958
p.A297E	DO228976	LICA	ICGC	STSTTSAVPSL	DEG_COP1_1	303:313	Mutation rewiring degron network	0.1667
p.S695Y	DO228978	LICA	ICGC	VRPYSD	LIG_APCC_ABBA_1	684:689	Mutation rewiring degron network	0.1667
p.T306N	DO229028	LICA	ICGC	STSTTSAVPSL	DEG_COP1_1	303:313	Mutation altering degron motif	0.5944
p.A309E	DO229009	LICA	ICGC	STSTTSAVPSL	DEG_COP1_1	303:313	Mutation altering degron motif	0.659
p.I698M	SIDM00884	Breast Carcinoma	GDSC	VRPYSD	LIG_APCC_ABBA_1	684:689	Mutation rewiring degron network	0.0833
p.I698M	ACH-000699	Breast Cancer	CCLE	VRPYSD	LIG_APCC_ABBA_1	684:689	Mutation rewiring degron network	0.0833
p.I698M	HCC1395	breast	COSMIC	VRPYSD	LIG_APCC_ABBA_1	684:689	Mutation rewiring degron network	0.0833
p.R685H	SIDM00258	Neuroblastoma	GDSC	VRPYSD	LIG_APCC_ABBA_1	684:689	Mutation altering degron motif	0.7133
p.R685H	ACH-002279	Neuroblastoma	CCLE	VRPYSD	LIG_APCC_ABBA_1	684:689	Mutation altering degron motif	0.7133
p.R685H	NB12	autonomic ganglia	COSMIC	VRPYSD	LIG_APCC_ABBA_1	684:689	Mutation altering degron motif	0.7133
p.V315I	SIDM00660	Colorectal Carcinoma	GDSC	STSTTSAVPSL	DEG_COP1_1	303:313	Mutation rewiring degron network	0.2778
p.V315I	ACH-000985	Colon/Colorectal Cancer	CCLE	STSTTSAVPSL	DEG_COP1_1	303:313	Mutation rewiring degron network	0.2778
p.V315I	LS-411N	large intestine	COSMIC	STSTTSAVPSL	DEG_COP1_1	303:313	Mutation rewiring degron network	0.2778
p.R685C	SIDM01566	Hodgkin's Lymphoma	GDSC	VRPYSD	LIG_APCC_ABBA_1	684:689	Mutation altering degron motif	0.719
p.R685C	ACH-000063	Non-Cancerous	CCLE	VRPYSD	LIG_APCC_ABBA_1	684:689	Mutation altering degron motif	0.719
p.R694Q	ACH-000973	Bladder Cancer	CCLE	VRPYSD	LIG_APCC_ABBA_1	684:689	Mutation rewiring degron network	0.1944

Kaplan plot for CCNT1 in

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CCNT1

UniProt ID: O60563

Entrez ID: 904

Protein name: Cyclin-T1 (CycT1) (Cyclin-T)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for CCNT1 in