DegronMD

Uniprot ID: O60563

Source protein: Cyclin-T1

Source gene: CCNT1

Class: LIG_APCC_ABBA_1

Location: 684:689

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9542

ASA_SCORE: 71

COIL: 0.6888

CONS_SCORE: 0.3888

DSS_SCORE: 0.4929

HELIX: 0.217

FCONS_SCORE: 1.0205

RIG_SCORE: 0.8002

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P686S	TCGA-97-A4M5	LUAD	TCGA	VRPYSD	LIG_APCC_ABBA_1	0.6752
p.P686S	DO218938	LUAD	ICGC	VRPYSD	LIG_APCC_ABBA_1	0.6752
p.T676I	TCGA-A8-A09Z	BRCA	TCGA	VRPYSD	LIG_APCC_ABBA_1	0.1111
p.T676I	DO5521	BRCA	ICGC	VRPYSD	LIG_APCC_ABBA_1	0.1111
p.S695Y	DO228978	LICA	ICGC	VRPYSD	LIG_APCC_ABBA_1	0.1667
p.I698M	SIDM00884	Breast Carcinoma	GDSC	VRPYSD	LIG_APCC_ABBA_1	0.0833
p.I698M	ACH-000699	Breast Cancer	CCLE	VRPYSD	LIG_APCC_ABBA_1	0.0833
p.I698M	HCC1395	breast	COSMIC	VRPYSD	LIG_APCC_ABBA_1	0.0833
p.R685H	SIDM00258	Neuroblastoma	GDSC	VRPYSD	LIG_APCC_ABBA_1	0.7133
p.R685H	ACH-002279	Neuroblastoma	CCLE	VRPYSD	LIG_APCC_ABBA_1	0.7133
p.R685H	NB12	autonomic_ganglia	COSMIC	VRPYSD	LIG_APCC_ABBA_1	0.7133
p.R685C	SIDM01566	Hodgkin's Lymphoma	GDSC	VRPYSD	LIG_APCC_ABBA_1	0.719
p.R685C	ACH-000063	Non-Cancerous	CCLE	VRPYSD	LIG_APCC_ABBA_1	0.719
p.R694Q	ACH-000973	Bladder Cancer	CCLE	VRPYSD	LIG_APCC_ABBA_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O60563	Cyclin-T1	LIG_APCC_ABBA_1	684:689	VRPYSD	APC,CDC20,FZR1	0.9542	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons