DegronMD

Uniprot ID: Q8WV99

Source protein: AN1-type zinc finger protein 2B

Source gene: ZFAND2B

Class: DEG_COP1_1

Location: 157:164

E3 ligase: COP1

DEGRON score: 0.7118

ASA_SCORE: 91.475

COIL: 0.8921

CONS_SCORE: 0.3164

DSS_SCORE: 0.6032

HELIX: 0.0967

FCONS_SCORE: 0.9518

RIG_SCORE: 0.6201

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A148V	TCGA-06-5416	GBM	TCGA	STSTVPSP	DEG_COP1_1	0.0833
p.A148V	DO10880	GBM	ICGC	STSTVPSP	DEG_COP1_1	0.0833
p.A148V	DO50669	ORCA	ICGC	STSTVPSP	DEG_COP1_1	0.0833
p.T158A	TCGA-12-5295	GBM	TCGA	STSTVPSP	DEG_COP1_1	0.7139
p.T158A	DO11848	GBM	ICGC	STSTVPSP	DEG_COP1_1	0.7139
p.I149T	TCGA-A3-3317	KIRC	TCGA	STSTVPSP	DEG_COP1_1	0.1111
p.I149T	TCGA-B0-4852	KIRC	TCGA	STSTVPSP	DEG_COP1_1	0.1111
p.I149T	DO19703	KIRC	ICGC	STSTVPSP	DEG_COP1_1	0.1111
p.I149S	TCGA-BQ-5881	KIRP	TCGA	STSTVPSP	DEG_COP1_1	0.1111
p.I149S	DO20865	KIRP	ICGC	STSTVPSP	DEG_COP1_1	0.1111
p.S159G	TCGA-CJ-5677	KIRC	TCGA	STSTVPSP	DEG_COP1_1	0.5882
p.S159G	DO19278	KIRC	ICGC	STSTVPSP	DEG_COP1_1	0.5882
p.C171Y	TCGA-EY-A215	UCEC	TCGA	STSTVPSP	DEG_COP1_1	0.1389
p.C171Y	DO42665	UCEC	ICGC	STSTVPSP	DEG_COP1_1	0.1389
p.V161I	TCGA-N7-A4Y0	UCS	TCGA	STSTVPSP	DEG_COP1_1	0.7076
p.A147T	DO222794	COCA	ICGC	STSTVPSP	DEG_COP1_1	0.0556
p.S159I	DO229015	LICA	ICGC	STSTVPSP	DEG_COP1_1	0.623
p.M168I	DO229025	LICA	ICGC	STSTVPSP	DEG_COP1_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8WV99	AN1-type zinc finger protein 2B	DEG_COP1_1	157:164	STSTVPSP	COP1	0.7118	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons