DegronMD

Uniprot ID: Q9HC84

Source protein: Mucin-5B

Source gene: MUC5B

Class: DEG_COP1_1

Location: 1646:1653

E3 ligase: COP1

DEGRON score: 0.9982

ASA_SCORE: 79.8625

COIL: 0.8446

CONS_SCORE: 0.2801

DSS_SCORE: 0.6717

HELIX: 0.0373

FCONS_SCORE: 1.059

RIG_SCORE: 0.6997

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P1637L	TCGA-2H-A9GN	ESCA	TCGA	STTAVPTL	DEG_COP1_1	0.0833
p.T1663R	TCGA-66-2766	LUSC	TCGA	STTAVPTL	DEG_COP1_1	0.0556
p.L1653P	TCGA-AP-A1DK	UCEC	TCGA	STTAVPTL	DEG_COP1_1	0.6471
p.R1661I	TCGA-AX-A2HC	UCEC	TCGA	STTAVPTL	DEG_COP1_1	0.1111
p.L1653R	TCGA-D3-A8GM	SKCM	TCGA	STTAVPTL	DEG_COP1_1	0.8428
p.E1655K	TCGA-EB-A553	SKCM	TCGA	STTAVPTL	DEG_COP1_1	0.2778
p.P1640L	DO222364	BTCA	ICGC	STTAVPTL	DEG_COP1_1	0.1667
p.S1639R	DO231967	LICA	ICGC	STTAVPTL	DEG_COP1_1	0.1389
p.P1636L	DO220073	SARC	ICGC	STTAVPTL	DEG_COP1_1	0.0556
p.L1656R	DO50288	SKCM	ICGC	STTAVPTL	DEG_COP1_1	0.25
p.E1658K	DO47329	SKCM	ICGC	STTAVPTL	DEG_COP1_1	0.1944
p.P1647L	DO42177	UCEC	ICGC	STTAVPTL	DEG_COP1_1	0.7582
p.L1656P	DO42033	UCEC	ICGC	STTAVPTL	DEG_COP1_1	0.25
p.V1650I	SIDM00333	Endometrial Carcinoma	GDSC	STTAVPTL	DEG_COP1_1	0.7076
p.V1650I	ACH-000988	Endometrial/Uterine Cancer	CCLE	STTAVPTL	DEG_COP1_1	0.7076
p.V1650I	MFE-319	endometrium	COSMIC	STTAVPTL	DEG_COP1_1	0.7076
p.P1637S	ACH-001997	Bile Duct Cancer	CCLE	STTAVPTL	DEG_COP1_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9HC84	Mucin-5B	DEG_COP1_1	1646:1653	STTAVPTL	COP1	0.9982	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons