DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
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Degron:
SVEQTPRK
Uniprot ID:
P49918
Source protein:
Cyclin-dependent kinase inhibitor 1C
Source gene:
CDKN1C
Class:
DEG_SCF_SKP2-CKS1_1
Location:
306:313
E3 ligase:
SKP2,CSK1
DEGRON score:
0.9955
ASA_SCORE:
109.7125
COIL:
0.8841
CONS_SCORE:
0.8056
DSS_SCORE:
0.8294
HELIX:
0.0782
FCONS_SCORE:
1.6428
RIG_SCORE:
0.6854
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with CDKN1C mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of SVEQTPRK
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
P49918
Cyclin-dependent kinase inhibitor 1C
DEG_SCF_SKP2-CKS1_1
306:313
SVEQTPRK
SKP2,CSK1
0.9955
More...