DegronMD

Uniprot ID: Q86UT8

Source protein: Centrosomal AT-AC splicing factor

Source gene: CENATAC

Class: DEG_COP1_1

Location: 168:178

E3 ligase: COP1

DEGRON score: 0.9567

ASA_SCORE: 68.7818

COIL: 0.6896

CONS_SCORE: 0.4275

DSS_SCORE: 0.6122

HELIX: 0.2345

FCONS_SCORE: 1.0825

RIG_SCORE: 0.6833

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A184V	TCGA-A5-A0GP	UCEC	TCGA	SVLEPQAVPDP	DEG_COP1_1	0.1667
p.A184V	DO41109	UCEC	ICGC	SVLEPQAVPDP	DEG_COP1_1	0.1667
p.P172S	TCGA-A5-A2K7	UCEC	TCGA	SVLEPQAVPDP	DEG_COP1_1	0.5641
p.P172S	DO41271	UCEC	ICGC	SVLEPQAVPDP	DEG_COP1_1	0.5641
p.Q173P	DO233804	GACA	ICGC	SVLEPQAVPDP	DEG_COP1_1	0.5924
p.P178S	DO229053	LICA	ICGC	SVLEPQAVPDP	DEG_COP1_1	0.6752
p.V169L	ACH-000971	Colon/Colorectal Cancer	CCLE	SVLEPQAVPDP	DEG_COP1_1	0.5654
p.V169L	HCT-116	large_intestine	COSMIC	SVLEPQAVPDP	DEG_COP1_1	0.5654
p.R167Q	ACH-002234	Head and Neck Cancer	CCLE	SVLEPQAVPDP	DEG_COP1_1	0.3056
p.R167Q	DOK	upper_aerodigestive_tract	COSMIC	SVLEPQAVPDP	DEG_COP1_1	0.3056
p.R162Q	NK-92MI	haematopoietic_and_lymphoid_tissue	COSMIC	SVLEPQAVPDP	DEG_COP1_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q86UT8	Centrosomal AT-AC splicing factor	DEG_COP1_1	168:178	SVLEPQAVPDP	COP1	0.9567	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons