DegronMD

Uniprot ID: Q04900

Source protein: Sialomucin core protein 24

Source gene: CD164

Class: DEG_COP1_1

Location: 110:120

E3 ligase: COP1

DEGRON score: 0.8931

ASA_SCORE: 86.4727

COIL: 0.9112

CONS_SCORE: 0.4686

DSS_SCORE: 0.3629

HELIX: 0.0208

FCONS_SCORE: 0.9701

RIG_SCORE: 0.7316

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V117M	TCGA-5P-A9JW	KIRP	TCGA	SVSTATPVPTA	DEG_COP1_1	0.7208
p.V117M	DO223943	KIRP	ICGC	SVSTATPVPTA	DEG_COP1_1	0.7208
p.P130S	TCGA-AD-6895	COAD	TCGA	SVSTATPVPTA	DEG_COP1_1	0.0556
p.P130S	DO8938	COAD	ICGC	SVSTATPVPTA	DEG_COP1_1	0.0556
p.P116T	TCGA-GN-A26D	SKCM	TCGA	SVSTATPVPTA	DEG_COP1_1	0.5919
p.P116T	DO37480	SKCM	ICGC	SVSTATPVPTA	DEG_COP1_1	0.5919
p.T105M	TCGA-XK-AAIW	PRAD	TCGA	SVSTATPVPTA	DEG_COP1_1	0.1944
p.T105M	DO51407	PRAD	ICGC	SVSTATPVPTA	DEG_COP1_1	0.1944
p.T112K	DO228976	LICA	ICGC	SVSTATPVPTA	DEG_COP1_1	0.7306
p.S122Y	DO229015	LICA	ICGC	SVSTATPVPTA	DEG_COP1_1	0.2778
p.K125E	DO230950	LUSC	ICGC	SVSTATPVPTA	DEG_COP1_1	0.3056
p.K125E	DO224638	LUSC	ICGC	SVSTATPVPTA	DEG_COP1_1	0.3056
p.S110A	DO220881	MELA	ICGC	SVSTATPVPTA	DEG_COP1_1	0.7588
p.S110V	DO220881	MELA	ICGC	SVSTATPVPTA	DEG_COP1_1	0.758
p.R125L	DO37703	SKCM	ICGC	SVSTATPVPTA	DEG_COP1_1	0.3056
p.T112I	DO42472	UCEC	ICGC	SVSTATPVPTA	DEG_COP1_1	0.7078
p.S110F	ACH-001275	Sarcoma	CCLE	SVSTATPVPTA	DEG_COP1_1	0.7982
p.A130G	NCI-H460	lung	COSMIC	SVSTATPVPTA	DEG_COP1_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q04900	Sialomucin core protein 24	DEG_COP1_1	110:120	SVSTATPVPTA	COP1	0.8931	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons