DegronMD

Uniprot ID: Q8WXI7

Source protein: Mucin-16

Source gene: MUC16

Class: DEG_COP1_1

Location: 11244:11253

E3 ligase: COP1

DEGRON score: 0.7813

ASA_SCORE: 92.25

COIL: 0.902

CONS_SCORE: 0

DSS_SCORE: 0.4625

HELIX: 0.0181

FCONS_SCORE: 0

RIG_SCORE: 0.7289

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A11246S	TCGA-55-8506	LUAD	TCGA	TEASSVVPTL	DEG_COP1_1	0.6477
p.A11246S	DO45390	LUAD	ICGC	TEASSVVPTL	DEG_COP1_1	0.6477
p.V11250F	TCGA-97-7546	LUAD	TCGA	TEASSVVPTL	DEG_COP1_1	0.7068
p.V11250F	DO23762	LUAD	ICGC	TEASSVVPTL	DEG_COP1_1	0.7068
p.E11259K	TCGA-A5-A0G2	UCEC	TCGA	TEASSVVPTL	DEG_COP1_1	0.1667
p.E11259K	DO41235	UCEC	ICGC	TEASSVVPTL	DEG_COP1_1	0.1667
p.D11236Y	TCGA-AA-3977	COAD	TCGA	TEASSVVPTL	DEG_COP1_1	0.1111
p.D11236Y	DO8730	COAD	ICGC	TEASSVVPTL	DEG_COP1_1	0.1111
p.N11263I	TCGA-D9-A6EC	SKCM	TCGA	TEASSVVPTL	DEG_COP1_1	0.0556
p.N11263I	DO50291	SKCM	ICGC	TEASSVVPTL	DEG_COP1_1	0.0556
p.V11250A	TCGA-EE-A2GO	SKCM	TCGA	TEASSVVPTL	DEG_COP1_1	0.6936
p.V11250A	DO37823	SKCM	ICGC	TEASSVVPTL	DEG_COP1_1	0.6936
p.W11238C	TCGA-FS-A1ZB	SKCM	TCGA	TEASSVVPTL	DEG_COP1_1	0.1667
p.W11238C	DO230343	COCA	ICGC	TEASSVVPTL	DEG_COP1_1	0.1667
p.W11238C	DO37886	SKCM	ICGC	TEASSVVPTL	DEG_COP1_1	0.1667
p.W11238C	SIDM00325	Esophageal Squamous Cell Carcinoma	GDSC	TEASSVVPTL	DEG_COP1_1	0.1667
p.W11238C	ACH-000694	Esophageal Cancer	CCLE	TEASSVVPTL	DEG_COP1_1	0.1667
p.W11238C	TE-9	oesophagus	COSMIC	TEASSVVPTL	DEG_COP1_1	0.1667
p.G11243R	TCGA-RP-A694	SKCM	TCGA	TEASSVVPTL	DEG_COP1_1	0.3056
p.G11243R	DO51269	SKCM	ICGC	TEASSVVPTL	DEG_COP1_1	0.3056
p.S11248Y	DO222884	COCA	ICGC	TEASSVVPTL	DEG_COP1_1	0.6009
p.T11252P	DO234449	ESAD	ICGC	TEASSVVPTL	DEG_COP1_1	0.7031
p.G11258C	DO231655	LINC	ICGC	TEASSVVPTL	DEG_COP1_1	0.1944
p.G11258V	DO231655	LINC	ICGC	TEASSVVPTL	DEG_COP1_1	0.1944
p.A11240T	DO229494	SKCA	ICGC	TEASSVVPTL	DEG_COP1_1	0.2222
p.E11245D	SIDM01266	Colorectal Carcinoma	GDSC	TEASSVVPTL	DEG_COP1_1	0.5647
p.H11241Q	SIDM00491	Thyroid Gland Carcinoma	GDSC	TEASSVVPTL	DEG_COP1_1	0.25
p.H11241Q	ACH-001443	Thyroid Cancer	CCLE	TEASSVVPTL	DEG_COP1_1	0.25
p.H11241Q	ASH-3	thyroid	COSMIC	TEASSVVPTL	DEG_COP1_1	0.25
p.P11260S	SIDM00660	Colorectal Carcinoma	GDSC	TEASSVVPTL	DEG_COP1_1	0.1389
p.P11260S	ACH-000985	Colon/Colorectal Cancer	CCLE	TEASSVVPTL	DEG_COP1_1	0.1389
p.P11260S	LS-411N	large_intestine	COSMIC	TEASSVVPTL	DEG_COP1_1	0.1389
p.P11260L	SIDM01242	Melanoma	GDSC	TEASSVVPTL	DEG_COP1_1	0.1389
p.P11260L	SIDM00151	Ovarian Carcinoma	GDSC	TEASSVVPTL	DEG_COP1_1	0.1389
p.P11260L	ACH-000966	Ovarian Cancer	CCLE	TEASSVVPTL	DEG_COP1_1	0.1389
p.P11260L	ACH-002084	Skin Cancer	CCLE	TEASSVVPTL	DEG_COP1_1	0.1389
p.P11260L	ACH-002162	Skin Cancer	CCLE	TEASSVVPTL	DEG_COP1_1	0.1389
p.P11260L	IGROV-1	ovary	COSMIC	TEASSVVPTL	DEG_COP1_1	0.1389
p.P11260L	MMAC-SF	skin	COSMIC	TEASSVVPTL	DEG_COP1_1	0.1389
p.W11238L	SIDM00325	Esophageal Squamous Cell Carcinoma	GDSC	TEASSVVPTL	DEG_COP1_1	0.1667
p.W11238L	SIDM00927	Small Cell Lung Carcinoma	GDSC	TEASSVVPTL	DEG_COP1_1	0.1667
p.W11238L	ACH-000694	Esophageal Cancer	CCLE	TEASSVVPTL	DEG_COP1_1	0.1667
p.W11238L	ACH-000871	Lung Cancer	CCLE	TEASSVVPTL	DEG_COP1_1	0.1667
p.W11238L	NCI-H510A	lung	COSMIC	TEASSVVPTL	DEG_COP1_1	0.1667
p.W11238L	TE-9	oesophagus	COSMIC	TEASSVVPTL	DEG_COP1_1	0.1667
p.P11251S	SIDM00056	Thyroid Gland Carcinoma	GDSC	TEASSVVPTL	DEG_COP1_1	0.6752
p.P11251S	ACH-002148	Thyroid Cancer	CCLE	TEASSVVPTL	DEG_COP1_1	0.6752
p.P11251S	K5	thyroid	COSMIC	TEASSVVPTL	DEG_COP1_1	0.6752

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: TEASSVVPTL

Degron related mutations and impact score

Drug responses associated with MUC16 mutations

All proteins holding degron of TEASSVVPTL

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8WXI7	Mucin-16	DEG_COP1_1	11244:11253	TEASSVVPTL	COP1	0.7813	More...