DegronMD

Uniprot ID: Q8WXI7

Source protein: Mucin-16

Source gene: MUC16

Class: DEG_COP1_1

Location: 11244:11253

E3 ligase: COP1

DEGRON score: 0.7813

ASA_SCORE: 92.25

COIL: 0.902

CONS_SCORE: 0

DSS_SCORE: 0.4625

HELIX: 0.0181

FCONS_SCORE: 0

RIG_SCORE: 0.7289

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V11250F	TCGA-97-7546	LUAD	TCGA	TEASSVVPTL	DEG_COP1_1	0.7068
p.V11250F	DO23762	LUAD	ICGC	TEASSVVPTL	DEG_COP1_1	0.7068
p.T11252P	DO234449	ESAD	ICGC	TEASSVVPTL	DEG_COP1_1	0.7031
p.V11250A	TCGA-EE-A2GO	SKCM	TCGA	TEASSVVPTL	DEG_COP1_1	0.6936
p.V11250A	DO37823	SKCM	ICGC	TEASSVVPTL	DEG_COP1_1	0.6936
p.P11251S	SIDM00056	Thyroid Gland Carcinoma	GDSC	TEASSVVPTL	DEG_COP1_1	0.6752
p.P11251S	ACH-002148	Thyroid Cancer	CCLE	TEASSVVPTL	DEG_COP1_1	0.6752
p.P11251S	K5	thyroid	COSMIC	TEASSVVPTL	DEG_COP1_1	0.6752
p.A11246S	TCGA-55-8506	LUAD	TCGA	TEASSVVPTL	DEG_COP1_1	0.6477
p.A11246S	DO45390	LUAD	ICGC	TEASSVVPTL	DEG_COP1_1	0.6477
p.S11248Y	DO222884	COCA	ICGC	TEASSVVPTL	DEG_COP1_1	0.6009
p.E11245D	SIDM01266	Colorectal Carcinoma	GDSC	TEASSVVPTL	DEG_COP1_1	0.5647
p.G11243R	TCGA-RP-A694	SKCM	TCGA	TEASSVVPTL	DEG_COP1_1	0.3056
p.G11243R	DO51269	SKCM	ICGC	TEASSVVPTL	DEG_COP1_1	0.3056
p.H11241Q	SIDM00491	Thyroid Gland Carcinoma	GDSC	TEASSVVPTL	DEG_COP1_1	0.25
p.H11241Q	ACH-001443	Thyroid Cancer	CCLE	TEASSVVPTL	DEG_COP1_1	0.25
p.H11241Q	ASH-3	thyroid	COSMIC	TEASSVVPTL	DEG_COP1_1	0.25
p.A11240T	DO229494	SKCA	ICGC	TEASSVVPTL	DEG_COP1_1	0.2222
p.G11258C	DO231655	LINC	ICGC	TEASSVVPTL	DEG_COP1_1	0.1944
p.G11258V	DO231655	LINC	ICGC	TEASSVVPTL	DEG_COP1_1	0.1944
p.E11259K	TCGA-A5-A0G2	UCEC	TCGA	TEASSVVPTL	DEG_COP1_1	0.1667
p.E11259K	DO41235	UCEC	ICGC	TEASSVVPTL	DEG_COP1_1	0.1667
p.W11238C	TCGA-FS-A1ZB	SKCM	TCGA	TEASSVVPTL	DEG_COP1_1	0.1667
p.W11238C	DO230343	COCA	ICGC	TEASSVVPTL	DEG_COP1_1	0.1667
p.W11238C	DO37886	SKCM	ICGC	TEASSVVPTL	DEG_COP1_1	0.1667

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8WXI7	Mucin-16	DEG_COP1_1	11244:11253	TEASSVVPTL	COP1	0.7813	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons