DegronMD

Uniprot ID: O15015

Source protein: Zinc finger protein 646

Source gene: ZNF646

Class: DEG_COP1_1

Location: 144:156

E3 ligase: COP1

DEGRON score: 0.9442

ASA_SCORE: 74.9769

COIL: 0.804

CONS_SCORE: 0.4757

DSS_SCORE: 0.716

HELIX: 0.1419

FCONS_SCORE: 1.0135

RIG_SCORE: 0.673

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G136D	TCGA-BG-A222	UCEC	TCGA	TEETPDCESVPDP	DEG_COP1_1	0.1111
p.G136D	DO42977	UCEC	ICGC	TEETPDCESVPDP	DEG_COP1_1	0.1111
p.T162M	DO222798	COCA	ICGC	TEETPDCESVPDP	DEG_COP1_1	0.1667
p.E146K	DO234232	ESAD	ICGC	TEETPDCESVPDP	DEG_COP1_1	0.7022
p.W163L	DO229008	LICA	ICGC	TEETPDCESVPDP	DEG_COP1_1	0.1389
p.S134G	DO50957	LICA	ICGC	TEETPDCESVPDP	DEG_COP1_1	0.0556
p.P148L	SIDM01251	T-Cell Non-Hodgkin's Lymphoma	GDSC	TEETPDCESVPDP	DEG_COP1_1	0.6471
p.P148L	ACH-002240	Lymphoma	CCLE	TEETPDCESVPDP	DEG_COP1_1	0.6471
p.P148L	H9	haematopoietic_and_lymphoid_tissue	COSMIC	TEETPDCESVPDP	DEG_COP1_1	0.6471
p.A159P	SIDM00721	Small Cell Lung Carcinoma	GDSC	TEETPDCESVPDP	DEG_COP1_1	0.25
p.A158V	SIDM00490	Glioma	GDSC	TEETPDCESVPDP	DEG_COP1_1	0.2778
p.A158V	ACH-001016	Brain Cancer	CCLE	TEETPDCESVPDP	DEG_COP1_1	0.2778
p.A158V	Becker	central_nervous_system	COSMIC	TEETPDCESVPDP	DEG_COP1_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O15015	Zinc finger protein 646	DEG_COP1_1	144:156	TEETPDCESVPDP	COP1	0.9442	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons