DegronMD

Uniprot ID: Q8WXI7

Source protein: Mucin-16

Source gene: MUC16

Class: DEG_COP1_1

Location: 2891:2900

E3 ligase: COP1

DEGRON score: 0.6724

ASA_SCORE: 97.34

COIL: 0.7265

CONS_SCORE: 0

DSS_SCORE: 0.4314

HELIX: 0.0248

FCONS_SCORE: 0

RIG_SCORE: 0.7744

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L2900F	TCGA-09-2044	OV	TCGA	TFEFSEVPSL	DEG_COP1_1	0.587
p.L2900F	DO28923	OV	ICGC	TFEFSEVPSL	DEG_COP1_1	0.587
p.Q2887K	TCGA-86-8673	LUAD	TCGA	TFEFSEVPSL	DEG_COP1_1	0.2222
p.Q2887K	DO26260	LUAD	ICGC	TFEFSEVPSL	DEG_COP1_1	0.2222
p.T2882A	TCGA-AP-A0LM	UCEC	TCGA	TFEFSEVPSL	DEG_COP1_1	0.0833
p.T2882A	DO43306	UCEC	ICGC	TFEFSEVPSL	DEG_COP1_1	0.0833
p.G2884R	TCGA-BF-AAP1	SKCM	TCGA	TFEFSEVPSL	DEG_COP1_1	0.1389
p.G2884R	DO219464	SKCM	ICGC	TFEFSEVPSL	DEG_COP1_1	0.1389
p.E2896D	TCGA-BQ-5876	KIRP	TCGA	TFEFSEVPSL	DEG_COP1_1	0.5647
p.E2896D	DO20759	KIRP	ICGC	TFEFSEVPSL	DEG_COP1_1	0.5647
p.T2902N	TCGA-BS-A0UV	UCEC	TCGA	TFEFSEVPSL	DEG_COP1_1	0.2778
p.T2902N	DO42793	UCEC	ICGC	TFEFSEVPSL	DEG_COP1_1	0.2778
p.S2899R	TCGA-E6-A1LX	UCEC	TCGA	TFEFSEVPSL	DEG_COP1_1	0.7427
p.S2899R	DO234220	ESAD	ICGC	TFEFSEVPSL	DEG_COP1_1	0.7427
p.S2899R	DO41020	UCEC	ICGC	TFEFSEVPSL	DEG_COP1_1	0.7427
p.S2906F	TCGA-EB-A3XF	SKCM	TCGA	TFEFSEVPSL	DEG_COP1_1	0.1667
p.S2906F	TCGA-GF-A6C9	SKCM	TCGA	TFEFSEVPSL	DEG_COP1_1	0.1667
p.S2906F	DO37437	SKCM	ICGC	TFEFSEVPSL	DEG_COP1_1	0.1667
p.S2906F	DO51254	SKCM	ICGC	TFEFSEVPSL	DEG_COP1_1	0.1667
p.S2899G	DO234422	ESAD	ICGC	TFEFSEVPSL	DEG_COP1_1	0.6993
p.K2903R	DO223149	ESCA	ICGC	TFEFSEVPSL	DEG_COP1_1	0.3611
p.P2886L	DO222908	MELA	ICGC	TFEFSEVPSL	DEG_COP1_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8WXI7	Mucin-16	DEG_COP1_1	2891:2900	TFEFSEVPSL	COP1	0.6724	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons