DegronMD

Uniprot ID: Q92729

Source protein: Receptor-type tyrosine-protein phosphatase U

Source gene: PTPRU

Class: DEG_COP1_1

Location: 478:489

E3 ligase: COP1

DEGRON score: 0.6165

ASA_SCORE: 67.2583

COIL: 0.6297

CONS_SCORE: 0.756

DSS_SCORE: 0.5113

HELIX: 0.0327

FCONS_SCORE: 0.9962

RIG_SCORE: 0.7654

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P468L	TCGA-AJ-A3IA	UCEC	TCGA	TFQTDEDVPSGI	DEG_COP1_1	0.0556
p.P468L	DO43082	UCEC	ICGC	TFQTDEDVPSGI	DEG_COP1_1	0.0556
p.V477I	TCGA-DU-6407	LGG	TCGA	TFQTDEDVPSGI	DEG_COP1_1	0.3056
p.V477I	DO22295	LGG	ICGC	TFQTDEDVPSGI	DEG_COP1_1	0.3056
p.T481M	TCGA-DX-A3UF	SARC	TCGA	TFQTDEDVPSGI	DEG_COP1_1	0.7423
p.T481M	DO219982	SARC	ICGC	TFQTDEDVPSGI	DEG_COP1_1	0.7423
p.E473D	TCGA-J2-A4AD	LUAD	TCGA	TFQTDEDVPSGI	DEG_COP1_1	0.1944
p.E473D	DO23915	LUAD	ICGC	TFQTDEDVPSGI	DEG_COP1_1	0.1944
p.E469D	DO225448	GACA	ICGC	TFQTDEDVPSGI	DEG_COP1_1	0.0833
p.S487I	DO229034	LICA	ICGC	TFQTDEDVPSGI	DEG_COP1_1	0.7341
p.G488E	DO222753	MELA	ICGC	TFQTDEDVPSGI	DEG_COP1_1	0.7199
p.K475T	DO232761	PBCA	ICGC	TFQTDEDVPSGI	DEG_COP1_1	0.3611
p.S493P	ACH-001991	Primary	CCLE	TFQTDEDVPSGI	DEG_COP1_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q92729	Receptor-type tyrosine-protein phosphatase U	DEG_COP1_1	478:489	TFQTDEDVPSGI	COP1	0.6165	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons