DegronMD

Uniprot ID: P49792

Source protein: E3 SUMO-protein ligase RanBP2

Source gene: RANBP2

Class: DEG_COP1_1

Location: 2780:2790

E3 ligase: COP1

DEGRON score: 0.9986

ASA_SCORE: 73.0818

COIL: 0.7539

CONS_SCORE: 0.3394

DSS_SCORE: 0.5007

HELIX: 0.0645

FCONS_SCORE: 1.0613

RIG_SCORE: 0.7611

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S2789Y	TCGA-A5-A2K5	UCEC	TCGA	TGGTEVMVPSF	DEG_COP1_1	0.712
p.S2789Y	DO41379	UCEC	ICGC	TGGTEVMVPSF	DEG_COP1_1	0.712
p.F2790L	TCGA-A8-A09A	BRCA	TCGA	TGGTEVMVPSF	DEG_COP1_1	0.587
p.F2790L	DO2955	BRCA	ICGC	TGGTEVMVPSF	DEG_COP1_1	0.587
p.F2790L	SIDM01242	Melanoma	GDSC	TGGTEVMVPSF	DEG_COP1_1	0.587
p.F2790L	SIDM01781	Gastric Carcinoma	GDSC	TGGTEVMVPSF	DEG_COP1_1	0.587
p.F2790L	SIDM01767	Squamous Cell Lung Carcinoma	GDSC	TGGTEVMVPSF	DEG_COP1_1	0.587
p.S2798Y	TCGA-AX-A05Z	UCEC	TCGA	TGGTEVMVPSF	DEG_COP1_1	0.5556
p.S2798Y	DO40884	UCEC	ICGC	TGGTEVMVPSF	DEG_COP1_1	0.5556
p.V2787G	TCGA-GS-A9TV	DLBC	TCGA	TGGTEVMVPSF	DEG_COP1_1	0.7532
p.V2787G	DO219914	DLBC	ICGC	TGGTEVMVPSF	DEG_COP1_1	0.7532
p.V2787I	DO233823	GACA	ICGC	TGGTEVMVPSF	DEG_COP1_1	0.7076
p.V2787I	SIDM00217	Colorectal Carcinoma	GDSC	TGGTEVMVPSF	DEG_COP1_1	0.7076
p.V2787I	ACH-000999	Colon/Colorectal Cancer	CCLE	TGGTEVMVPSF	DEG_COP1_1	0.7076
p.V2787I	SNU-1040	large_intestine	COSMIC	TGGTEVMVPSF	DEG_COP1_1	0.7076

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P49792	E3 SUMO-protein ligase RanBP2	DEG_COP1_1	2780:2790	TGGTEVMVPSF	COP1	0.9986	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons