DegronMD

Uniprot ID: P22314

Source protein: Ubiquitin-like modifier-activating enzyme 1

Source gene: UBA1

Class: DEG_APCC_TPR_1

Location: 1056:1058

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.961

ASA_SCORE: 65.7

COIL: 0.3633

CONS_SCORE: 0.3142

DSS_SCORE: 0.6343

HELIX: 0.0023

FCONS_SCORE: 0.6237

RIG_SCORE: 0.8775

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R1058C	TCGA-A5-A1OF	UCEC	TCGA	TIR	DEG_APCC_TPR_1	0.8301
p.R1058C	DO42568	UCEC	ICGC	TIR	DEG_APCC_TPR_1	0.8301
p.R1058S	TCGA-AP-A059	UCEC	TCGA	TIR	DEG_APCC_TPR_1	0.7427
p.R1058S	DO41361	UCEC	ICGC	TIR	DEG_APCC_TPR_1	0.7427
p.E1046K	SIDM00596	Endometrial Carcinoma	GDSC	TIR	DEG_APCC_TPR_1	0.0556
p.E1046K	ACH-000941	Endometrial/Uterine Cancer	CCLE	TIR	DEG_APCC_TPR_1	0.0556
p.E1046K	ACH-000954	Endometrial/Uterine Cancer	CCLE	TIR	DEG_APCC_TPR_1	0.0556
p.E1046K	ACH-001517	Endometrial/Uterine Cancer	CCLE	TIR	DEG_APCC_TPR_1	0.0556
p.E1046K	HEC-1	endometrium	COSMIC	TIR	DEG_APCC_TPR_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P22314	Ubiquitin-like modifier-activating enzyme 1	DEG_APCC_TPR_1	1056:1058	TIR	APC,CDC20,FZR1	0.961	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons