DegronMD

Uniprot ID: Q68D51

Source protein: DENN domain-containing protein 2C

Source gene: DENND2C

Class: DEG_APCC_KENBOX_2

Location: 317:321

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9223

ASA_SCORE: 94.26

COIL: 0.9146

CONS_SCORE: 0.3855

DSS_SCORE: 0.3755

HELIX: 0.049

FCONS_SCORE: 1.0507

RIG_SCORE: 0.7683

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D324G	TCGA-06-0152	GBM	TCGA	TKENP	DEG_APCC_KENBOX_2	0.25
p.D324G	DO11238	GBM	ICGC	TKENP	DEG_APCC_KENBOX_2	0.25
p.E311G	TCGA-86-8359	LUAD	TCGA	TKENP	DEG_APCC_KENBOX_2	0.1667
p.E311G	DO25817	LUAD	ICGC	TKENP	DEG_APCC_KENBOX_2	0.1667
p.K318E	TCGA-AA-A010	COAD	TCGA	TKENP	DEG_APCC_KENBOX_2	0.7022
p.Y322C	TCGA-B5-A1MX	UCEC	TCGA	TKENP	DEG_APCC_KENBOX_2	0.3056
p.Y322C	DO41999	UCEC	ICGC	TKENP	DEG_APCC_KENBOX_2	0.3056
p.P321L	TCGA-W3-AA1R	SKCM	TCGA	TKENP	DEG_APCC_KENBOX_2	0.6471
p.P321L	DO51275	SKCM	ICGC	TKENP	DEG_APCC_KENBOX_2	0.6471
p.D307E	DO229015	LICA	ICGC	TKENP	DEG_APCC_KENBOX_2	0.0556
p.E323K	DO219878	SKCA	ICGC	TKENP	DEG_APCC_KENBOX_2	0.2778
p.E323D	SIDM00919	Ovarian Carcinoma	GDSC	TKENP	DEG_APCC_KENBOX_2	0.2778
p.E323D	ACH-000713	Ovarian Cancer	CCLE	TKENP	DEG_APCC_KENBOX_2	0.2778
p.E323D	Caov-3	ovary	COSMIC	TKENP	DEG_APCC_KENBOX_2	0.2778
p.P321S	ACH-002508	Skin Cancer	CCLE	TKENP	DEG_APCC_KENBOX_2	0.5641

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q68D51	DENN domain-containing protein 2C	DEG_APCC_KENBOX_2	317:321	TKENP	APC,CDC20,FZR1	0.9223	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons