DegronMD - Q68D51(DENND2C)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.D324G	TCGA-06-0152	GBM	TCGA	TKENP	DEG_APCC_KENBOX_2	317:321	Mutation rewiring degron network	0.25
p.D324G	DO11238	GBM	ICGC	TKENP	DEG_APCC_KENBOX_2	317:321	Mutation rewiring degron network	0.25
p.Y219C	TCGA-56-7822	LUSC	TCGA	VTPYKE	DEG_SCF_FBW7_2	225:230	Mutation rewiring degron network	0.1667
p.Y219C	TCGA-56-7822	LUSC	TCGA	VTPYKE	LIG_APCC_ABBA_1	225:230	Mutation rewiring degron network	0.1667
p.Y219C	DO26638	LUSC	ICGC	VTPYKE	DEG_SCF_FBW7_2	225:230	Mutation rewiring degron network	0.1667
p.Y219C	DO26638	LUSC	ICGC	VTPYKE	LIG_APCC_ABBA_1	225:230	Mutation rewiring degron network	0.1667
p.E311G	TCGA-86-8359	LUAD	TCGA	TKENP	DEG_APCC_KENBOX_2	317:321	Mutation rewiring degron network	0.1667
p.E311G	DO25817	LUAD	ICGC	TKENP	DEG_APCC_KENBOX_2	317:321	Mutation rewiring degron network	0.1667
p.T216S	TCGA-A5-A0G1	UCEC	TCGA	VTPYKE	DEG_SCF_FBW7_2	225:230	Mutation rewiring degron network	0.0833
p.T216S	TCGA-A5-A0G1	UCEC	TCGA	VTPYKE	LIG_APCC_ABBA_1	225:230	Mutation rewiring degron network	0.0833
p.T216S	DO42472	UCEC	ICGC	VTPYKE	DEG_SCF_FBW7_2	225:230	Mutation rewiring degron network	0.0833
p.T216S	DO42472	UCEC	ICGC	VTPYKE	LIG_APCC_ABBA_1	225:230	Mutation rewiring degron network	0.0833
p.E222K	TCGA-A5-A2K5	UCEC	TCGA	VTPYKE	DEG_SCF_FBW7_2	225:230	Mutation rewiring degron network	0.25
p.E222K	TCGA-A5-A2K5	UCEC	TCGA	VTPYKE	LIG_APCC_ABBA_1	225:230	Mutation rewiring degron network	0.25
p.E222K	TCGA-CV-A45Z	HNSC	TCGA	VTPYKE	DEG_SCF_FBW7_2	225:230	Mutation rewiring degron network	0.25
p.E222K	TCGA-CV-A45Z	HNSC	TCGA	VTPYKE	LIG_APCC_ABBA_1	225:230	Mutation rewiring degron network	0.25
p.E222K	DO52064	HNSC	ICGC	VTPYKE	DEG_SCF_FBW7_2	225:230	Mutation rewiring degron network	0.25
p.E222K	DO52064	HNSC	ICGC	VTPYKE	LIG_APCC_ABBA_1	225:230	Mutation rewiring degron network	0.25
p.E222K	DO41379	UCEC	ICGC	VTPYKE	DEG_SCF_FBW7_2	225:230	Mutation rewiring degron network	0.25
p.E222K	DO41379	UCEC	ICGC	VTPYKE	LIG_APCC_ABBA_1	225:230	Mutation rewiring degron network	0.25
p.K318E	TCGA-AA-A010	COAD	TCGA	TKENP	DEG_APCC_KENBOX_2	317:321	Mutation altering degron motif	0.7022
p.E239G	TCGA-AZ-4315	COAD	TCGA	VTPYKE	DEG_SCF_FBW7_2	225:230	Mutation rewiring degron network	0.0833
p.E239G	TCGA-AZ-4315	COAD	TCGA	VTPYKE	LIG_APCC_ABBA_1	225:230	Mutation rewiring degron network	0.0833
p.E239G	DO8842	COAD	ICGC	VTPYKE	DEG_SCF_FBW7_2	225:230	Mutation rewiring degron network	0.0833
p.E239G	DO8842	COAD	ICGC	VTPYKE	LIG_APCC_ABBA_1	225:230	Mutation rewiring degron network	0.0833
p.R215M	TCGA-AZ-4615	COAD	TCGA	VTPYKE	DEG_SCF_FBW7_2	225:230	Mutation rewiring degron network	0.0556
p.R215M	TCGA-AZ-4615	COAD	TCGA	VTPYKE	LIG_APCC_ABBA_1	225:230	Mutation rewiring degron network	0.0556
p.R215M	DO7977	COAD	ICGC	VTPYKE	DEG_SCF_FBW7_2	225:230	Mutation rewiring degron network	0.0556
p.R215M	DO7977	COAD	ICGC	VTPYKE	LIG_APCC_ABBA_1	225:230	Mutation rewiring degron network	0.0556
p.Y322C	TCGA-B5-A1MX	UCEC	TCGA	TKENP	DEG_APCC_KENBOX_2	317:321	Mutation rewiring degron network	0.3056
p.Y322C	DO41999	UCEC	ICGC	TKENP	DEG_APCC_KENBOX_2	317:321	Mutation rewiring degron network	0.3056
p.Y237H	TCGA-DM-A1D8	COAD	TCGA	VTPYKE	DEG_SCF_FBW7_2	225:230	Mutation rewiring degron network	0.1389
p.Y237H	TCGA-DM-A1D8	COAD	TCGA	VTPYKE	LIG_APCC_ABBA_1	225:230	Mutation rewiring degron network	0.1389
p.Y237H	DO8914	COAD	ICGC	VTPYKE	DEG_SCF_FBW7_2	225:230	Mutation rewiring degron network	0.1389
p.Y237H	DO8914	COAD	ICGC	VTPYKE	LIG_APCC_ABBA_1	225:230	Mutation rewiring degron network	0.1389
p.P321L	TCGA-W3-AA1R	SKCM	TCGA	TKENP	DEG_APCC_KENBOX_2	317:321	Mutation altering degron motif	0.6471
p.P321L	DO51275	SKCM	ICGC	TKENP	DEG_APCC_KENBOX_2	317:321	Mutation altering degron motif	0.6471
p.D307E	DO229015	LICA	ICGC	TKENP	DEG_APCC_KENBOX_2	317:321	Mutation rewiring degron network	0.0556
p.D234E	DO229025	LICA	ICGC	VTPYKE	DEG_SCF_FBW7_2	225:230	Mutation rewiring degron network	0.2222
p.D234E	DO229025	LICA	ICGC	VTPYKE	LIG_APCC_ABBA_1	225:230	Mutation rewiring degron network	0.2222
p.R231K	DO222363	MELA	ICGC	VTPYKE	DEG_SCF_FBW7_2	225:230	Mutation rewiring degron network	0.3056
p.R231K	DO222363	MELA	ICGC	VTPYKE	LIG_APCC_ABBA_1	225:230	Mutation rewiring degron network	0.3056
p.P227L	DO232761	PBCA	ICGC	VTPYKE	DEG_SCF_FBW7_2	225:230	Mutation altering degron motif	0.7582
p.P227L	DO232761	PBCA	ICGC	VTPYKE	LIG_APCC_ABBA_1	225:230	Mutation altering degron motif	0.6471
p.E323K	DO219878	SKCA	ICGC	TKENP	DEG_APCC_KENBOX_2	317:321	Mutation rewiring degron network	0.2778
p.S223P	SIDM00944	Colorectal Carcinoma	GDSC	VTPYKE	DEG_SCF_FBW7_2	225:230	Mutation blocking phosphorylation signal	0.7222
p.S223P	SIDM00944	Colorectal Carcinoma	GDSC	VTPYKE	LIG_APCC_ABBA_1	225:230	Mutation blocking phosphorylation signal	0.7222
p.S223P	SIDM00096	T-Cell Non-Hodgkin's Lymphoma	GDSC	VTPYKE	DEG_SCF_FBW7_2	225:230	Mutation blocking phosphorylation signal	0.7222
p.S223P	SIDM00096	T-Cell Non-Hodgkin's Lymphoma	GDSC	VTPYKE	LIG_APCC_ABBA_1	225:230	Mutation blocking phosphorylation signal	0.7222
p.S223P	SIDM00660	Colorectal Carcinoma	GDSC	VTPYKE	DEG_SCF_FBW7_2	225:230	Mutation blocking phosphorylation signal	0.7222
p.S223P	SIDM00660	Colorectal Carcinoma	GDSC	VTPYKE	LIG_APCC_ABBA_1	225:230	Mutation blocking phosphorylation signal	0.7222
p.S223P	SIDM00112	Kidney Carcinoma	GDSC	VTPYKE	DEG_SCF_FBW7_2	225:230	Mutation blocking phosphorylation signal	0.7222
p.S223P	SIDM00112	Kidney Carcinoma	GDSC	VTPYKE	LIG_APCC_ABBA_1	225:230	Mutation blocking phosphorylation signal	0.7222
p.S223P	SIDM00749	Non-Small Cell Lung Carcinoma	GDSC	VTPYKE	DEG_SCF_FBW7_2	225:230	Mutation blocking phosphorylation signal	0.7222
p.S223P	SIDM00749	Non-Small Cell Lung Carcinoma	GDSC	VTPYKE	LIG_APCC_ABBA_1	225:230	Mutation blocking phosphorylation signal	0.7222
p.S223P	SIDM00785	Acute Myeloid Leukemia	GDSC	VTPYKE	DEG_SCF_FBW7_2	225:230	Mutation blocking phosphorylation signal	0.7222
p.S223P	SIDM00785	Acute Myeloid Leukemia	GDSC	VTPYKE	LIG_APCC_ABBA_1	225:230	Mutation blocking phosphorylation signal	0.7222
p.S223P	SIDM00628	Breast Carcinoma	GDSC	VTPYKE	DEG_SCF_FBW7_2	225:230	Mutation blocking phosphorylation signal	0.7222
p.S223P	SIDM00628	Breast Carcinoma	GDSC	VTPYKE	LIG_APCC_ABBA_1	225:230	Mutation blocking phosphorylation signal	0.7222
p.E323D	SIDM00919	Ovarian Carcinoma	GDSC	TKENP	DEG_APCC_KENBOX_2	317:321	Mutation rewiring degron network	0.2778
p.E323D	ACH-000713	Ovarian Cancer	CCLE	TKENP	DEG_APCC_KENBOX_2	317:321	Mutation rewiring degron network	0.2778
p.E323D	Caov-3	ovary	COSMIC	TKENP	DEG_APCC_KENBOX_2	317:321	Mutation rewiring degron network	0.2778
p.E222A	SIDM00562	Breast Carcinoma	GDSC	VTPYKE	DEG_SCF_FBW7_2	225:230	Mutation rewiring degron network	0.25
p.E222A	SIDM00562	Breast Carcinoma	GDSC	VTPYKE	LIG_APCC_ABBA_1	225:230	Mutation rewiring degron network	0.25
p.E222A	SIDM00054	Pancreatic Carcinoma	GDSC	VTPYKE	DEG_SCF_FBW7_2	225:230	Mutation rewiring degron network	0.25
p.E222A	SIDM00054	Pancreatic Carcinoma	GDSC	VTPYKE	LIG_APCC_ABBA_1	225:230	Mutation rewiring degron network	0.25
p.E222A	SIDM01163	Non-Small Cell Lung Carcinoma	GDSC	VTPYKE	DEG_SCF_FBW7_2	225:230	Mutation rewiring degron network	0.25
p.E222A	SIDM01163	Non-Small Cell Lung Carcinoma	GDSC	VTPYKE	LIG_APCC_ABBA_1	225:230	Mutation rewiring degron network	0.25
p.T226M	SIDM01608	Endometrial Carcinoma	GDSC	VTPYKE	DEG_SCF_FBW7_2	225:230	Mutation altering degron motif	0.7423
p.T226M	SIDM01608	Endometrial Carcinoma	GDSC	VTPYKE	LIG_APCC_ABBA_1	225:230	Mutation altering degron motif	0.6312
p.P321S	ACH-002508	Skin Cancer	CCLE	TKENP	DEG_APCC_KENBOX_2	317:321	Mutation altering degron motif	0.5641

DegronMD: protein-targeted degradation, mutation and drug response to degrons

DENND2C

UniProt ID: Q68D51

Entrez ID: 163259

Protein name: DENN domain-containing protein 2C

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for DENND2C in