DegronMD

Uniprot ID: Q68D51

Source protein: DENN domain-containing protein 2C

Source gene: DENND2C

Class: DEG_SCF_FBW7_2

Location: 225:230

E3 ligase: FBXW7

DEGRON score: 0.8889

ASA_SCORE: 93.35

COIL: 0.7842

CONS_SCORE: 0.2788

DSS_SCORE: 0.3586

HELIX: 0.1787

FCONS_SCORE: 0.8967

RIG_SCORE: 0.7351

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Y219C	TCGA-56-7822	LUSC	TCGA	VTPYKE	DEG_SCF_FBW7_2	0.1667
p.Y219C	TCGA-56-7822	LUSC	TCGA	VTPYKE	LIG_APCC_ABBA_1	0.1667
p.Y219C	DO26638	LUSC	ICGC	VTPYKE	DEG_SCF_FBW7_2	0.1667
p.Y219C	DO26638	LUSC	ICGC	VTPYKE	LIG_APCC_ABBA_1	0.1667
p.T216S	TCGA-A5-A0G1	UCEC	TCGA	VTPYKE	DEG_SCF_FBW7_2	0.0833
p.T216S	TCGA-A5-A0G1	UCEC	TCGA	VTPYKE	LIG_APCC_ABBA_1	0.0833
p.T216S	DO42472	UCEC	ICGC	VTPYKE	DEG_SCF_FBW7_2	0.0833
p.T216S	DO42472	UCEC	ICGC	VTPYKE	LIG_APCC_ABBA_1	0.0833
p.E222K	TCGA-A5-A2K5	UCEC	TCGA	VTPYKE	DEG_SCF_FBW7_2	0.25
p.E222K	TCGA-A5-A2K5	UCEC	TCGA	VTPYKE	LIG_APCC_ABBA_1	0.25
p.E222K	TCGA-CV-A45Z	HNSC	TCGA	VTPYKE	DEG_SCF_FBW7_2	0.25
p.E222K	TCGA-CV-A45Z	HNSC	TCGA	VTPYKE	LIG_APCC_ABBA_1	0.25
p.E222K	DO52064	HNSC	ICGC	VTPYKE	DEG_SCF_FBW7_2	0.25
p.E222K	DO52064	HNSC	ICGC	VTPYKE	LIG_APCC_ABBA_1	0.25
p.E222K	DO41379	UCEC	ICGC	VTPYKE	DEG_SCF_FBW7_2	0.25
p.E222K	DO41379	UCEC	ICGC	VTPYKE	LIG_APCC_ABBA_1	0.25
p.E239G	TCGA-AZ-4315	COAD	TCGA	VTPYKE	DEG_SCF_FBW7_2	0.0833
p.E239G	TCGA-AZ-4315	COAD	TCGA	VTPYKE	LIG_APCC_ABBA_1	0.0833
p.E239G	DO8842	COAD	ICGC	VTPYKE	DEG_SCF_FBW7_2	0.0833
p.E239G	DO8842	COAD	ICGC	VTPYKE	LIG_APCC_ABBA_1	0.0833
p.R215M	TCGA-AZ-4615	COAD	TCGA	VTPYKE	DEG_SCF_FBW7_2	0.0556
p.R215M	TCGA-AZ-4615	COAD	TCGA	VTPYKE	LIG_APCC_ABBA_1	0.0556
p.R215M	DO7977	COAD	ICGC	VTPYKE	DEG_SCF_FBW7_2	0.0556
p.R215M	DO7977	COAD	ICGC	VTPYKE	LIG_APCC_ABBA_1	0.0556
p.Y237H	TCGA-DM-A1D8	COAD	TCGA	VTPYKE	DEG_SCF_FBW7_2	0.1389
p.Y237H	TCGA-DM-A1D8	COAD	TCGA	VTPYKE	LIG_APCC_ABBA_1	0.1389
p.Y237H	DO8914	COAD	ICGC	VTPYKE	DEG_SCF_FBW7_2	0.1389
p.Y237H	DO8914	COAD	ICGC	VTPYKE	LIG_APCC_ABBA_1	0.1389
p.D234E	DO229025	LICA	ICGC	VTPYKE	DEG_SCF_FBW7_2	0.2222
p.D234E	DO229025	LICA	ICGC	VTPYKE	LIG_APCC_ABBA_1	0.2222
p.R231K	DO222363	MELA	ICGC	VTPYKE	DEG_SCF_FBW7_2	0.3056
p.R231K	DO222363	MELA	ICGC	VTPYKE	LIG_APCC_ABBA_1	0.3056
p.P227L	DO232761	PBCA	ICGC	VTPYKE	DEG_SCF_FBW7_2	0.7582
p.P227L	DO232761	PBCA	ICGC	VTPYKE	LIG_APCC_ABBA_1	0.6471
p.S223P	SIDM00944	Colorectal Carcinoma	GDSC	VTPYKE	DEG_SCF_FBW7_2	0.7222
p.S223P	SIDM00944	Colorectal Carcinoma	GDSC	VTPYKE	LIG_APCC_ABBA_1	0.7222
p.S223P	SIDM00096	T-Cell Non-Hodgkin's Lymphoma	GDSC	VTPYKE	DEG_SCF_FBW7_2	0.7222
p.S223P	SIDM00096	T-Cell Non-Hodgkin's Lymphoma	GDSC	VTPYKE	LIG_APCC_ABBA_1	0.7222
p.S223P	SIDM00660	Colorectal Carcinoma	GDSC	VTPYKE	DEG_SCF_FBW7_2	0.7222
p.S223P	SIDM00660	Colorectal Carcinoma	GDSC	VTPYKE	LIG_APCC_ABBA_1	0.7222
p.S223P	SIDM00112	Kidney Carcinoma	GDSC	VTPYKE	DEG_SCF_FBW7_2	0.7222
p.S223P	SIDM00112	Kidney Carcinoma	GDSC	VTPYKE	LIG_APCC_ABBA_1	0.7222
p.S223P	SIDM00749	Non-Small Cell Lung Carcinoma	GDSC	VTPYKE	DEG_SCF_FBW7_2	0.7222
p.S223P	SIDM00749	Non-Small Cell Lung Carcinoma	GDSC	VTPYKE	LIG_APCC_ABBA_1	0.7222
p.S223P	SIDM00785	Acute Myeloid Leukemia	GDSC	VTPYKE	DEG_SCF_FBW7_2	0.7222
p.S223P	SIDM00785	Acute Myeloid Leukemia	GDSC	VTPYKE	LIG_APCC_ABBA_1	0.7222
p.S223P	SIDM00628	Breast Carcinoma	GDSC	VTPYKE	DEG_SCF_FBW7_2	0.7222
p.S223P	SIDM00628	Breast Carcinoma	GDSC	VTPYKE	LIG_APCC_ABBA_1	0.7222
p.E222A	SIDM00562	Breast Carcinoma	GDSC	VTPYKE	DEG_SCF_FBW7_2	0.25
p.E222A	SIDM00562	Breast Carcinoma	GDSC	VTPYKE	LIG_APCC_ABBA_1	0.25
p.E222A	SIDM00054	Pancreatic Carcinoma	GDSC	VTPYKE	DEG_SCF_FBW7_2	0.25
p.E222A	SIDM00054	Pancreatic Carcinoma	GDSC	VTPYKE	LIG_APCC_ABBA_1	0.25
p.E222A	SIDM01163	Non-Small Cell Lung Carcinoma	GDSC	VTPYKE	DEG_SCF_FBW7_2	0.25
p.E222A	SIDM01163	Non-Small Cell Lung Carcinoma	GDSC	VTPYKE	LIG_APCC_ABBA_1	0.25
p.T226M	SIDM01608	Endometrial Carcinoma	GDSC	VTPYKE	DEG_SCF_FBW7_2	0.7423
p.T226M	SIDM01608	Endometrial Carcinoma	GDSC	VTPYKE	LIG_APCC_ABBA_1	0.6312

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VTPYKE

Degron related mutations and impact score

Drug responses associated with DENND2C mutations

All proteins holding degron of VTPYKE

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q68D51	DENN domain-containing protein 2C	DEG_SCF_FBW7_2	225:230	VTPYKE	FBXW7	0.8889	More...
Q68D51	DENN domain-containing protein 2C	LIG_APCC_ABBA_1	225:230	VTPYKE	APC,CDC20,FZR1	0.8889	More...