DegronMD

Uniprot ID: Q96BU1

Source protein: S100P-binding protein

Source gene: S100PBP

Class: DEG_COP1_1

Location: 304:313

E3 ligase: COP1

DEGRON score: 0.9765

ASA_SCORE: 96.37

COIL: 0.8698

CONS_SCORE: 0.6297

DSS_SCORE: 0.4937

HELIX: 0.0279

FCONS_SCORE: 0.7589

RIG_SCORE: 0.7742

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P310L	DO228542	GACA	ICGC	TKTRTNVPTF	DEG_COP1_1	0.7582
p.K304N	DO49976	CESC	ICGC	TKTRTNVPTF	DEG_COP1_1	0.6918
p.K305N	TCGA-JW-A5VL	CESC	TCGA	TKTRTNVPTF	DEG_COP1_1	0.5806
p.Q322K	DO229257	THCA	ICGC	TKTRTNVPTF	DEG_COP1_1	0.5278
p.Q303H	ACH-000586	Lung Cancer	CCLE	TKTRTNVPTF	DEG_COP1_1	0.3056
p.Q303H	NCI-H1876	lung	COSMIC	TKTRTNVPTF	DEG_COP1_1	0.3056

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96BU1	S100P-binding protein	DEG_COP1_1	304:313	TKTRTNVPTF	COP1	0.9765	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons