DegronMD

Uniprot ID: Q6NZY4

Source protein: Zinc finger CCHC domain-containing protein 8

Source gene: ZCCHC8

Class: DEG_COP1_1

Location: 577:586

E3 ligase: COP1

DEGRON score: 0.5636

ASA_SCORE: 91.53

COIL: 0.793

CONS_SCORE: 0.2448

DSS_SCORE: 0.6766

HELIX: 0.1608

FCONS_SCORE: 0.9195

RIG_SCORE: 0.7203

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E580K	TCGA-E7-A7XN	BLCA	TCGA	TLDEPEVPEI	DEG_COP1_1	0.591
p.I586M	TCGA-F5-6814	READ	TCGA	TLDEPEVPEI	DEG_COP1_1	0.6507
p.T577M	TCGA-KN-8435	KICH	TCGA	TLDEPEVPEI	DEG_COP1_1	0.8534
p.T577M	NCI-H2172	lung	COSMIC	TLDEPEVPEI	DEG_COP1_1	0.8534
p.P568R	Jurkat	haematopoietic_and_lymphoid_tissue	COSMIC	TLDEPEVPEI	DEG_COP1_1	0.0833
p.P584S	JHH-1	liver	COSMIC	TLDEPEVPEI	DEG_COP1_1	0.6752
p.E582D	SNU-C2B	large_intestine	COSMIC	TLDEPEVPEI	DEG_COP1_1	0.5647

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6NZY4	Zinc finger CCHC domain-containing protein 8	DEG_COP1_1	577:586	TLDEPEVPEI	COP1	0.5636	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons