DegronMD

Uniprot ID: E9PAV3

Source protein: Nascent polypeptide-associated complex subunit alpha, muscle-specific form

Source gene: NACA

Class: DEG_COP1_1

Location: 694:704

E3 ligase: COP1

DEGRON score: 0.9279

ASA_SCORE: 90.0727

COIL: 0.9501

CONS_SCORE: 0.4422

DSS_SCORE: 0.4478

HELIX: 0.0145

FCONS_SCORE: 1.5529

RIG_SCORE: 0.7604

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G699A	TCGA-CF-A47X	BLCA	TCGA	TLTTLPLVPTA	DEG_COP1_1	0.754
p.P693L	TCGA-VQ-A8P2	STAD	TCGA	TLTTLPLVPTA	DEG_COP1_1	0.3056
p.P693L	SIDM00951	T-Lymphoblastic Leukemia	GDSC	TLTTLPLVPTA	DEG_COP1_1	0.3056
p.P693L	CTV-1	haematopoietic_and_lymphoid_tissue	COSMIC	TLTTLPLVPTA	DEG_COP1_1	0.3056
p.S697F	TCGA-WE-A8K5	SKCM	TCGA	TLTTLPLVPTA	DEG_COP1_1	0.7982
p.P712A	DO2401	BRCA	ICGC	TLTTLPLVPTA	DEG_COP1_1	0.1111
p.P714L	DO37543	SKCM	ICGC	TLTTLPLVPTA	DEG_COP1_1	0.0556
p.P685L	DO37567	SKCM	ICGC	TLTTLPLVPTA	DEG_COP1_1	0.0833
p.P712S	DO51246	SKCM	ICGC	TLTTLPLVPTA	DEG_COP1_1	0.1111
p.G698R	SIDM01016	T-Lymphoblastic Leukemia	GDSC	TLTTLPLVPTA	DEG_COP1_1	0.7568
p.G698R	Jurkat	haematopoietic_and_lymphoid_tissue	COSMIC	TLTTLPLVPTA	DEG_COP1_1	0.7568
p.V705I	SIDM00783	Colorectal Carcinoma	GDSC	TLTTLPLVPTA	DEG_COP1_1	0.3056
p.V705I	HCT-116	large_intestine	COSMIC	TLTTLPLVPTA	DEG_COP1_1	0.3056
p.K691E	ACH-000891	Lung Cancer	CCLE	TLTTLPLVPTA	DEG_COP1_1	0.3611
p.S713P	ACH-000989	Colon/Colorectal Cancer	CCLE	TLTTLPLVPTA	DEG_COP1_1	0.0833
p.S713P	SNU-175	large_intestine	COSMIC	TLTTLPLVPTA	DEG_COP1_1	0.0833
p.L695R	ACH-000996	Endometrial/Uterine Cancer	CCLE	TLTTLPLVPTA	DEG_COP1_1	0.7316
p.S705L	ACH-002181	Ovarian Cancer	CCLE	TLTTLPLVPTA	DEG_COP1_1	0.3056
p.S705L	OVCA420	ovary	COSMIC	TLTTLPLVPTA	DEG_COP1_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
E9PAV3	Nascent polypeptide-associated complex subunit alpha, muscle-specific form	DEG_COP1_1	694:704	TLTTLPLVPTA	COP1	0.9279	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons