DegronMD

Uniprot ID: O43251

Source protein: RNA binding protein fox-1 homolog 2

Source gene: RBFOX2

Class: DEG_SIAH_1

Location: 27:35

E3 ligase: SIAH1,SIAH2,SIAH3

DEGRON score: 0.5421

ASA_SCORE: 83.3778

COIL: 0.872

CONS_SCORE: 0.4115

DSS_SCORE: 0.7657

HELIX: 0.1047

FCONS_SCORE: 1.0571

RIG_SCORE: 0.7169

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P33S	TCGA-SQ-A6I6	PCPG	TCGA	TPDAMVQPF	DEG_SIAH_1	0.6752
p.G39E	DO222895	BTCA	ICGC	TPDAMVQPF	DEG_SIAH_1	0.2222
p.A20T	DO8119	COAD	ICGC	TPDAMVQPF	DEG_SIAH_1	0.1389
p.A20T	DO50142	STAD	ICGC	TPDAMVQPF	DEG_SIAH_1	0.1389
p.A20T	DO43186	UCEC	ICGC	TPDAMVQPF	DEG_SIAH_1	0.1389
p.A20T	SW1783	central_nervous_system	COSMIC	TPDAMVQPF	DEG_SIAH_1	0.1389
p.T40S	DO25535	LUAD	ICGC	TPDAMVQPF	DEG_SIAH_1	0.1944
p.L41P	DO220258	SARC	ICGC	TPDAMVQPF	DEG_SIAH_1	0.1667
p.P39S	DO219481	SKCM	ICGC	TPDAMVQPF	DEG_SIAH_1	0.2222
p.D19N	DO40810	UCEC	ICGC	TPDAMVQPF	DEG_SIAH_1	0.1111
p.D38Y	ACH-000436	Myeloma	CCLE	TPDAMVQPF	DEG_SIAH_1	0.25
p.P29S	LNCaP-Clone-FGC	prostate	COSMIC	TPDAMVQPF	DEG_SIAH_1	0.6752
p.V44L	CESS	haematopoietic_and_lymphoid_tissue	COSMIC	TPDAMVQPF	DEG_SIAH_1	0.0833
p.P34L	CRO-AP3	NS	COSMIC	TPDAMVQPF	DEG_SIAH_1	0.7582
p.V24L	CESS	haematopoietic_and_lymphoid_tissue	COSMIC	TPDAMVQPF	DEG_SIAH_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O43251	RNA binding protein fox-1 homolog 2	DEG_SIAH_1	27:35	TPDAMVQPF	SIAH1,SIAH2,SIAH3	0.5421	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons