DegronMD

Uniprot ID: Q8N8Z3

Source protein: Putative uncharacterized protein DIP2C-AS1

Source gene: DIP2C-AS1

Class: DEG_SIAH_1

Location: 165:173

E3 ligase: SIAH1,SIAH2,SIAH3

DEGRON score: 0.9653

ASA_SCORE: 67.0444

COIL: 0.8331

CONS_SCORE: 1

DSS_SCORE: 0.5558

HELIX: 0.0644

FCONS_SCORE: 1

RIG_SCORE: 0.6498

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S171G	DO38376	STAD	ICGC	TPPALVSPT	DEG_SIAH_1	0.5882
p.L158F	ACH-000971	Colon/Colorectal Cancer	CCLE	TPPALVSPT	DEG_SIAH_1	0.1389
p.L158F	HCT-116	large_intestine	COSMIC	TPPALVSPT	DEG_SIAH_1	0.1389
p.P167L	ACH-001318	Liver Cancer	CCLE	TPPALVSPT	DEG_SIAH_1	0.6471
p.P179H	ACH-001613	Leukemia	CCLE	TPPALVSPT	DEG_SIAH_1	0.1667
p.G183R	MFE-319	endometrium	COSMIC	TPPALVSPT	DEG_SIAH_1	0.0556
p.G183R	LU-99A	lung	COSMIC	TPPALVSPT	DEG_SIAH_1	0.0556
p.P161S	AsPC-1	pancreas	COSMIC	TPPALVSPT	DEG_SIAH_1	0.2222
p.Q155E	LP-1	haematopoietic_and_lymphoid_tissue	COSMIC	TPPALVSPT	DEG_SIAH_1	0.0556
p.Q155E	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	TPPALVSPT	DEG_SIAH_1	0.0556
p.S164N	BT-483	breast	COSMIC	TPPALVSPT	DEG_SIAH_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8N8Z3	Putative uncharacterized protein DIP2C-AS1	DEG_SIAH_1	165:173	TPPALVSPT	SIAH1,SIAH2,SIAH3	0.9653	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons